Oxidases

Mason, Howard S.

doi:10.1146/annurev.bi.34.070165.003115

Cited by 260 publications

(88 citation statements)

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“…Conversely, placing Cul' in a site distorted towards a planar configuration will decrease the activation energy for oxidation. Thus, a configuration intermediate between the square planar case (normal for Cu2' ) and the tetrahedral case (normal for Cul+) is well suited for rapid electron transport, since no large changes in ligand geometry will have to occur during the cyclic process [23,24].…”

Section: In the Crystals Containingmentioning

confidence: 99%

Cu2+ in Non Axial-Field: A Model for Cu2+ in Copper Enzymes

Gould

Ehrenberg

1968

Eur J Biochem

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By y-irradiation a t 77" K of the Cul'-containing organic crystals, Cu(CH,CN),C10,, Cu(HOOCCH,CH,CN),C10,, and Cu(CH,CN),BF,, Cu2' centres in near-tetrahedral field were produced. These Cu2+ centres approximated the electron spin resonance characteristics ( IAl; 1 . = 0.008 cm-l) and light absorption of Cu2+ in Cu-containing oxidoreductases. No exact correlation was found between the g-values of the model system and the Cu-oxidases. It is suggested that the Cu site in these enzymes is intermediate between the square planar (normal for Cu2+) and the tetrahedral (normal for Cul+) configuration, which makes it suited for rapid electron transport.

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Section: In the Crystals Containingmentioning

confidence: 99%

Cu2+ in Non Axial-Field: A Model for Cu2+ in Copper Enzymes

Gould

Ehrenberg

1968

Eur J Biochem

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“…Tyrosinase (monophenol,dihydroxyphenylalanine : oxygen oxidoreductase, EC 1.14.18.1 ; and catechol oxidase, EC 1.10.3.1) is a type III copper protein and is an important enzyme participating in the process of melanin biosynthesis [2]. The enzyme catalyses both the o-hydroxylation of monophenols to o-diphenols (cresolase ; EC 1.14.18.1) and the oxidation of odiphenols to o-quinones (catechol oxidase ; EC 1.10.3.1.…”

Section: Introductionmentioning

confidence: 99%

“…of lignins, bioflavonoids, tannin, adrenaline and other compounds ; the starting materials for these compounds are phenols [2]. Albinism, which is due to a lack of melanin pigment, is one of the oldest known mutations in mice [3].…”

Section: Introductionmentioning

confidence: 99%

Identification of copper ligands in Aspergillus oryzae tyrosinase by site-directed mutagenesis

et al. 2000

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“…PPO1 and PPO2 are primarily expressed in crystal cells while PPO3 is mainly expressed in lamellocytes when Drosophila melanogaster was infected by parasite [12][13][14]. Nine PPO genes have been identified in Anopheles gambiae [15,16] while ten and three genes in Aedes aegypti and Culex quinquefasciatus, respectively [17]. In the honey bee Apis mellifera, the PPO cDNA was characterized [18].…”

Section: Introductionmentioning

confidence: 99%