Oxidants, Antioxidants and Oxidative Stress

Ďuračková, Zdeňka; Gvozdjáková, A

doi:10.1007/978-1-4020-6714-3_2

Cited by 18 publications

(16 citation statements)

References 114 publications

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“…Trace elements as a component of oxidative stress are suggested to be a good indicator for diagnosing various diseases. Oxidative stress is an important contributing factor in the pathogenesis of many diseases, including also DM [3][4][5]. Several studies have confirmed that hyperglycemia plays a key role in inducing oxidative stress in DM [6,7].…”

Section: Introductionmentioning

confidence: 97%

Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

et al. 2009

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Section: Introductionmentioning

confidence: 97%

Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

et al. 2009

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“…High training loads in endurance athletes imply the possibility of excessive production of free radicals [6]; even during recovery from physical exercise, blood cells themselves can produce significant amounts of ROS. Excessive production of free radicals can cause damage to DNA or tissues such as lipids and proteins [7]. In addition, contractile dysfunction related to oxidative damage and muscular fatigue can occur when ROS levels exceed the capacity of the antioxidant system during irregular or strenuous and sustained exercise [8,9], thus making diagnosis vital.…”

Section: Introductionmentioning

confidence: 99%

Association between Parameters Related to Oxidative Stress and Trace Minerals in Athletes

et al. 2020

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The aim of the present study was to evaluate the basal concentrations of malondialdehyde (MDA) nonenzymatic antioxidants, such as ascorbic acid, α-tocopherol, and retinol in plasma or erythrocytes, and the plasma concentrations of 16 trace minerals in endurance athletes from Extremadura (Spain). In addition, we aimed to assess the possible relationships between some parameters related to cellular oxidative stress with plasma concentrations of some trace minerals. Sixty-two national long-distance men athletes participated in this study. The parameters related to oxidative stress and antioxidant activity were analyzed through high pressure liquid chromatography (HPLC), and trace minerals analysis was performed by inductively coupled plasma mass spectrometry (ICP-MS). We found that plasma MDA was positively correlated with selenium and rubidium. Plasma ascorbic acid was positively correlated with manganese and negatively correlated with cobalt and cadmium. Erythrocyte ascorbic acid was related to arsenic and cesium. Plasma α-tocopherol correlated with copper and manganese negatively and positively with arsenic. Erythrocyte α-tocopherol was positively related to copper, rubidium, and lithium. The findings show that athletes with a high degree of training should monitor their intake and concentrations of α-tocopherol for its fundamental role of neutralizing the excess of reactive oxygen species produced by exercise and the prooxidant effects of several minerals such as arsenic, copper, and lithium.

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“…Following a stress event, superoxide dismutase converts the potentially damaging superoxide anion into oxygen and H 2 O 2 and catalase then breaks down H 2 O 2 into oxygen and water [ 98 , 99 ]. The delay in these enzymes observed in triploids may cause cells to be exposed to harmful levels of reactive oxygen species for extended periods of time which could result in cell injury or death, and DNA damage [ 100 , 101 ]. A similar delayed response in triploids was also detected in the hypoferraemic response, a bacterial defence mechanism [ 102 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative ploidy response to experimental hydrogen peroxide exposure in Atlantic salmon (Salmo salar)

Chalmers

Vera

Taylor

et al. 2018

Fish & Shellfish Immunology

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While research into the growth, survival, nutrition and, more recently, disease susceptibility of triploid Atlantic salmon has expanded, there remains an overall lack of studies assessing the response of triploids to chemical treatments. It is essential that the response of triploids to disease treatments be characterised to validate their suitability for commercial production. This study aimed to investigate and compare the stress and immune responses of triploid and diploid Atlantic salmon following an experimental treatment with hydrogen peroxide (H2O2). A dose response test was first undertaken to determine a suitable test dose for both diploid and triploid Atlantic salmon. Following this, diploids and triploids were exposed to H2O2 (1800 ppm) for 20 min, as per commercial practices, after which blood glucose and lactate, and plasma cortisol and lysozyme were measured, along with the expression of oxidative stress and immune-related genes. In the first 6 h post-exposure to H2O2, comparable mortalities occurred in both diploid and triploid Atlantic salmon. Cortisol, glucose and lactate were not significantly influenced by ploidy suggesting that, physiologically, triploid Atlantic salmon are able to cope with the stress associated with H2O2 exposure as well as their diploid counterparts. Exposure to H2O2 significantly elevated the expression of cat and sod2 in diploid livers and gr, il1β and crp/sap1b in diploid gills, while it significantly decreased the expression of saa5 and crp/sap1a in diploid gills. In triploids, the expression levels of cat, hsp70, sod1, saa5, crp/sap1a and crp/sap1b in liver was significantly higher in fish exposed to H2O2 compared to control fish. The expression of gr, sod1 and il1β in triploid gills was also elevated in response to H2O2 exposure. This study represents the first experimental evidence of the effects of H2O2 exposure on triploid Atlantic salmon and continues to support their application into commercial production.

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Oxidants, Antioxidants and Oxidative Stress

Cited by 18 publications

References 114 publications

Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

Association between Parameters Related to Oxidative Stress and Trace Minerals in Athletes

Comparative ploidy response to experimental hydrogen peroxide exposure in Atlantic salmon (Salmo salar)

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