Oxidants and antioxidants in tonsillar and adenoidal tissue in chronic adenotonsillitis and adenotonsillar hypertrophy in children

Kıroğlu, Ahmet Faruk; Noyan, Tevfik; Oger, M.; Kara, T.C.

doi:10.1016/j.ijporl.2005.05.006

Cited by 21 publications

(14 citation statements)

References 12 publications

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“…The main difficulty in interpreting our results is the lack of a proper method to measure the exact amount of reactive radicals the pDCs have to face in situ [41]. Another issue that should be considered is that although infection and inflammation are characterized by increased production of ROS, levels of enzymatic and nonenzymatic antioxidants are also elevated in affected tissues to balance the harmful effects of oxidation products [42–44]. Furthermore, inflammation enhances vascular permeability, allowing plasma antioxidant substances to move into inflamed tissues [45–48].…”

Section: Discussionmentioning

confidence: 99%

Modulatory effects of low-dose hydrogen peroxide on the function of human plasmacytoid dendritic cells

Pázmándi

Magyarics

Boldogh

et al. 2012

Free Radical Biology and Medicine

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Under normal conditions, plasmacytoid dendritic cells (pDCs) are located in peripheral lymphoid organs or circulate in the blood, from where they can migrate to sites of infection or inflammation. In inflamed tissues, pDCs can be exposed to elevated levels of reactive oxygen species produced by inflammatory cells and we presume that oxidative stress could affect the cellular responses of pDCs to microenvironmental stimuli. To explore this possibility, human pDCs isolated from peripheral blood of healthy donors were treated with H2O2 and R837 (a Toll-like receptor 7 ligand), separately and in combination. Our results demonstrate that treatment with a low concentration (0.01 µM) of H2O2 resulted in only slight changes in the expression of CD40, CD80, CD86, and CD83; however, low-dose H2O2 markedly decreased the expression of HLA-DQ on pDCs. Exposure to H2O2 did not trigger the release of IL-6, TNF-α, IL-8, or IFN-α from pDCs. Although addition of H2O2 did not modify the capacity of pDCs to activate allogeneic IL-17- or IFN-γ-producing T cells, it significantly increased the ability of pDCs to stimulate IL-4-secreting T cells. Exposure of pDCs to H2O2 before cocultivation with naïve autologous T cells significantly lowered IL-10 production by T cells, but did not affect IL-17 release. It was also observed that H2O2-exposed pDCs provided stronger stimuli for Th2 than for Th1 differentiation upon autologous activation, compared to untreated pDCs, possibly because of elevated surface expression of OX40-L. Most importantly, when pDCs were stimulated with R837 in the presence of H2O2, decreased phenotypic activation, decreased chemokine and cytokine release, and impaired allo- and autostimulatory functions of pDCs were detected, indicating that pDCs exposed to oxidative stress in vivo may have an anti-inflammatory or tolerogenic role in regulating adaptive immune responses.

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Section: Discussionmentioning

confidence: 99%

Modulatory effects of low-dose hydrogen peroxide on the function of human plasmacytoid dendritic cells

Pázmándi

Magyarics

Boldogh

et al. 2012

Free Radical Biology and Medicine

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“…Children with obstructive adenoidal hypertrophy have evidence of greater blood and urine markers of oxidative DNA damage compared with children without adenoid disease [81]. It has also been shown that oxidants and antioxidants play an important role in both adenotonsillar hypertrophy and chronic adenotonsillitis, but that oxidative levels differed between the two pathologies, suggesting different disease states [82].…”

Section: Genetics/immunologymentioning

confidence: 99%

Adenoidectomy in Children: What Is the Evidence and What Is its Role?

Schüpper

Nation

Pransky

2018

Curr Otorhinolaryngol Rep

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Purpose of Review Review the current state of the adenoidectomy procedure in the pediatric population with up-to-date indications for surgery, operative techniques, adverse events, non-surgical management of adenoid hypertrophy, and future directions. Recent Findings Adenoidectomy is indicated in children for the treatment of sleep-disordered breathing, nasal airway obstruction, recurrent acute otitis media, and chronic rhinosinusitis. A new recommendation was released in 2016, not supporting adenoidectomy for a primary indication of otitis media in children under 4 years old, including those with prior tympanostomy tubes, unless a distinct indication exists such as nasal obstruction or chronic adenoiditis. Although adenotonsillectomy is the mainstay of treatment for obstructive sleep apnea (OSA), recent studies have identified that non-obese patients with moderate OSA and small tonsils have comparable benefits with adenoidectomy alone with less complications. While conventional approaches such as indirect mirror-assisted curette and suction coagulation are still utilized, direct transnasal endoscopeassisted removal of the adenoids has proven to be a safe technique, with good short-and long-term outcomes. Novel nonsurgical therapies including immunotherapy have been evaluated. Summary Adenoidectomy is a safe procedure in the pediatric population and leads to excellent outcomes. Adverse events are rare, and hospitalization is uncommon. Children with sleep disturbance from nasal airway obstruction, ear disease, or chronic rhinosinusitis are the best operative candidates for this procedure.

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“…Kiroglu et al 15 reported that the preoperative blood erythrocyte malondialdehyde (MDA), serum MDA, erythrocyte catalase and serum catalase levels and adenoid and tonsil tissue levels of MDA and catalase were higher in chronic adenotonsillitis patients than in children with adenotonsillary hypertrophy. Kaygusuz et al 16 investigated chronic tonsillitis patients, and found that oxidative stress increased and SOD activity decreased in parallel with an increase in the generation of MDA by lipid peroxidation that resulted in tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Acta Otorhinolaryngologica Italica

Özbay

Kucur

Koçak

et al. 2016

Acta Otorhinolaryngol Ital

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Lobiettivo del presente studio è stato determinare se i livelli plasmatici dei prodotti avanzati di ossidazione proteica (AOPP) rappresentino dei marker di stress ossidativo nei pazienti pediatrici affetti da tonsillite cronica. Per lo studio sono stati arruolati, presso i Dipartimenti di Otorinolaringoiatria e Chirurgia pediatrica dellOspedale Universitario di Dumlupinar, trenta bambini sani e trenta affetti da tonsillite cronica. Il gruppo dei pazienti affetti da malattia è stato sottoposto a un prelievo ematico preoperatorio e ad una biopsia intraoperatoria del tessuto tonsillare. Il gruppo dei pazienti sani è stato sottoposto unicamente al prelievo ematico. I livelli plasmatici e tissutali degli AOPP sono quindi stati misurati mediante spettrofotometria. I livelli sierici degli AOPP sono risultati essere più elevati nel gruppo dei pazienti affetti da tonsillite cronica (13,1 ± 3,3 ng/ml) rispetto al gruppo di controllo (11,6 ± 2,3 ng/ml; P < 0,05). Il livello tissutale medio degli AOPP nei pazienti malati è risultato essere superiore a quello plasmatico medio sia nel gruppo dei pazienti sani che in quello dei pazienti malati (41,9 ± 13,5 ng/mg; P < 0,05). I livelli plasmatici e tissutali degli AOPP sono risultati quindi essere più elevati nei pazienti malati rispetto al gruppo di controllo. Gli AOPP potrebbero quindi rappresentare una nuova classe di molecole pro-infiammatorie coinvolte nello stress ossidativo nella tonsillite cronica e potrebbero avere un ruolo come marker di stress ossidativo nei pazienti pediatrici affetti da tale patologia.

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Oxidants and antioxidants in tonsillar and adenoidal tissue in chronic adenotonsillitis and adenotonsillar hypertrophy in children

Cited by 21 publications

References 12 publications

Modulatory effects of low-dose hydrogen peroxide on the function of human plasmacytoid dendritic cells

Modulatory effects of low-dose hydrogen peroxide on the function of human plasmacytoid dendritic cells

Adenoidectomy in Children: What Is the Evidence and What Is its Role?

Acta Otorhinolaryngologica Italica

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