Oxidant production and immune response after stretch injury in skeletal muscle

Brickson, Stacey; Hollander, John M.; Corr, David T.; Ji, Li Li; Best, Thomas M.

doi:10.1097/00005768-200112000-00006

Cited by 51 publications

(49 citation statements)

References 27 publications

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“…One possibility is that the enhanced expression of iNOS was caused by the infiltration and activation of neutrophils, which are known to release inflammatory cytokines [26]. Consistent with this hypothesis, our previous study showed an increase in myeloperoxidase activity, a biochemical marker for neutrophil presence, in injured muscles at 4 h and 48 h following injury [27]. Neutrophils undergo the respiratory burst to generate reactive oxygen species as signaling molecules to activate the nuclear factor (NFκB) and, in turn, iNOS activation [28].…”

Section: Macrophage Lysate Was Used As a Positive Control (Pc) (B)supporting

confidence: 54%

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Changes in Nitric Oxide and Inducible Nitric Oxide Synthase Following Stretch-Induced Injury to the Tibialis Anterior Muscle of Rabbit

Sakurai

Hollander²,

Brickson

et al. 2005

JJP

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This study investigated the changes in nitric oxide (NO) together with inducible nitric oxide synthase (iNOS) content and enzyme activity at 0, 4, 12, 24, and 48 h following acute muscle stretch injury. A single stretch injury was induced to the tibialis anterior muscle of 30 male New Zealand white rabbits (n = 6 at each time point). Injured and uninjured contralateral sham-operated muscles were harvested and analyzed for NO levels, iNOS content, and iNOS activity at each time point. Furthermore, three animals were used to estimate baseline NO levels and iNOS activity. There was a progressive reduction in NO content Nitric oxide (NO) generation occurs through the conversion of L-arginine to NO and L-citrulline, which is controlled by NO synthases (NOS) [1]. There are three forms of NOS that catalyze NO production [2]. NO is a ubiquitous molecule involved in a variety of physiological functions, including vascular regulation, neurotransmission, immune regulation, and cell signaling [3][4][5]. NO is also known to have profound effects on skeletal muscle function, including contractility, blood vessel tone, blood flow, and satellite cell activation [6][7][8][9]. Resting skeletal muscle contains two constitutive types, neural NOS (nNOS) and, to a lesser extent, endothelial NOS (eNOS) [7,10,11]. The third or inducible form (iNOS) is expressed mainly in leukocytes and macrophages in response to inflammation. In contrast to eNOS and nNOS, iNOS can produce large amounts of NO over a prolonged period [12,13],

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Section: Macrophage Lysate Was Used As a Positive Control (Pc) (B)supporting

confidence: 54%

“…Using a similar injury protocol, we previously reported an increase in the rate of oxidant production at 24 h after operation and injury in the sham-operated and stretch-injured muscles [27]. This increase paralleled an increase in xanthine oxidase activity, suggesting that O 2…”

Section: Macrophage Lysate Was Used As a Positive Control (Pc) (B)mentioning

confidence: 69%

Changes in Nitric Oxide and Inducible Nitric Oxide Synthase Following Stretch-Induced Injury to the Tibialis Anterior Muscle of Rabbit

Sakurai

Hollander²,

Brickson

et al. 2005

JJP

Self Cite

View full text Add to dashboard Cite

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“…The mean value was significantly different from that of the control trial: * P < 0·05, ** P < 0·01. phagocytes progressively accumulate in the muscle and initiate inflammatory events that precede tissue repair, including releasing reactive species that can help degrade cellular debris (2,(33)(34)(35)(36) . It has been assumed that reactive species released by phagocytes could occasionally act on intact structures, leading to additional damage and delayed recovery of muscle strength (3,(5)(6)(7)(8)33) .…”

Section: Discussionmentioning

confidence: 99%

“…It has been assumed that reactive species released by phagocytes could occasionally act on intact structures, leading to additional damage and delayed recovery of muscle strength (3,(5)(6)(7)(8)33) . Neutrophils are the first phagocytes to invade the muscle, typically peaking in concentration between 6 and 24 h after damage and then quickly decreasing in numbers (8,(34)(35)(36) . Phagocytic macrophage concentrations are elevated at 24 h and peak about 48 h after injury (6,35,36) .…”

Section: Discussionmentioning

confidence: 99%

Effects of mate tea consumption on muscle strength and oxidative stress markers after eccentric exercise

et al. 2016

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Dietary phytochemical supplementation may improve muscle recovery from exercise. In this study, we investigated the effect of mate tea (MT) consumption -a phenol-rich beverage -on muscle strength and oxidative stress biomarkers after eccentric exercise. In a randomised, crossover design, twelve men were assigned to drink either MT or water (control; CON) for 11 d. On the 8th day, subjects performed three sets of twenty maximal eccentric elbow flexion exercises. Maximal isometric elbow flexion force was measured before and at 0, 24, 48 and 72 h after exercise. Blood samples were obtained before and at 24, 48 and 72 h after exercise and analysed for total phenolics, GSH, GSSG, GSH:GSSG ratio and lipid hydroperoxides (LOOH). After eccentric exercise, muscle strength was significantly reduced over time, regardless of treatments. However, MT improved the rate of strength recovery by 8·6 % on the 1st day after exercise (P < 0·05). Plasma concentration of total phenolic compounds was higher in MT than in CON at all time points (P < 0·05) but decreased significantly at 72 h after exercise in both trials (P < 0·05). Blood levels of GSH were significantly decreased at 48 and 72 h after exercise in CON (P < 0·05) but did not change over time in MT. No significant changes were observed for GSSG, GSH:GSSG ratio and LOOH levels. MT intake did not influence muscle strength at all time points assessed but hastened the strength recovery over 24 h after exercise. MT also favoured the concentration of blood antioxidant compounds.

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“…The activation of the muscle fiber increases the release of calcium (Ca 2 +), leading to the synthesis of pro-inflammatory cytokines, including tumor necrosis factor alpha (TNF-α) and IL-1β, which regulate the expression of selections by the endothelial cells that attract circulating neutrophils to the region. IL-6 and IL-8 cytokines, which are secreted after tissue damage, stimulate the signaling pathway that activates NADPH-oxidase causing the release of reactive oxygen species 40 . Wolach et al 41 examined the effect of anaerobic exercise (Wingate test) and aerobic exercise (performed at 70-80% of HRmax) on the function of neutrophil in female judo athletes compared to sedentary women.…”

Section: Physical Exercise Effect On Cells Of the Immune System Neutrmentioning

confidence: 99%

Efeito do exercício no sistema imune: resposta, adaptação e sinalização celular

Terra

Da-Silva

Salerno

et al. 2012

Rev Bras Med Esporte

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Introduction: Over the last century, people have become less active, adopting more sedentary habits. This scenario has increased the incidence of chronic diseases such as cardiovascular diseases, type 2 diabetes and metabolic syndrome. The practice of physical activities can influence healthiness by altering the metabolic state and also the immune system. Objective: To review the literature for studies that address the effects promoted by physical exercise on the development of immune responses and the possible signal transduction pathways. Methods: The SciELO and PubMed data bases were consulted. Results: The available literature shows that during the practice of exercise, various subpopulations of leukocytes are altered in accordance with the intensity and duration of the activity performed. Exercise of moderate intensity stimulates a pro-inflammatory response, while those of high intensity tend to promote antiinflammatory responses that could decrease damage to skeletal muscle. Such alterations are observed in cells that present antigens (such as macrophages and dendritic cells), neutrophils, natural killer cells (NK) and in surface molecules like Toll-like receptors (TLR) and major histocompatibility complex class II, as well as the entire repertoire of cytokines. Conclusion: The current state of knowledge suggests that the alterations in the immune system are dependent on parameters inherent to exercise and that in order to have all these alterations occurring, some cell signaling cascades are activated, giving rise to a complex process of phosphorylation/dephosphorylation that culminates in the activation of transcription factors, translation of mRNA's, protein synthesis and cell proliferation.

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Oxidant production and immune response after stretch injury in skeletal muscle

Cited by 51 publications

References 27 publications

Changes in Nitric Oxide and Inducible Nitric Oxide Synthase Following Stretch-Induced Injury to the Tibialis Anterior Muscle of Rabbit

Changes in Nitric Oxide and Inducible Nitric Oxide Synthase Following Stretch-Induced Injury to the Tibialis Anterior Muscle of Rabbit

Effects of mate tea consumption on muscle strength and oxidative stress markers after eccentric exercise

Efeito do exercício no sistema imune: resposta, adaptação e sinalização celular

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