Oxidant-induced dopamine polymerization for multifunctional coatings

Wei, Qiang; Zhang, Fulong; Li, Jie; Li, Beijia; Zhao, Changsheng

doi:10.1039/c0py00215a

Cited by 658 publications

(567 citation statements)

References 29 publications

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“…23,24 Polymerization of DA solution (1 mM) in PBS (pH 7.4) was in situ investigated using UV−vis spectroscopy for 3 h (see the Supporting Information, Figure S1). After NaOH addition (final concentration is 20 mM), a peak around 350 nm appeared which indicates the quinone formation 24 and its intensity gradually increased for 3 h. The broad peak around 470 nm shows the intramolecular cyclization of the quinone derivative 24 which is an intermediate product in the polymerization of DA (see the Supporting Information, inset of Figure S1). 23 After 10 min, this broad peak disappeared and absorption at all wavelengths between 400 and 700 nm increased gradually, which shows the formation of PDA.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…23 After 10 min, this broad peak disappeared and absorption at all wavelengths between 400 and 700 nm increased gradually, which shows the formation of PDA. 24 In order to characterize the PDA nanoparticles formed after 3 h of oxidization reaction, we polymerized 100 μM DA using 20 mM NaOH. Particle size distribution of PDA nanoparticles is given in Figure 1, which shows the broad size distribution of particles with diameters ranging from a few nanometers to hundreds of nanometers.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Turn-on Fluorescent Dopamine Sensing Based on in Situ Formation of Visible Light Emitting Polydopamine Nanoparticles

2014

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Dopamine is the principle biomarker for diseases such as schizophrenia, Huntington's, and Parkinson's, and the need is urgent for rapid and sensitive detection methods for diagnosis and monitoring of such diseases. In this Article, we report a turn-on fluorescent method for rapid dopamine sensing which is based on monitoring the intrinsic fluorescence of in situ synthesized polydopamine nanoparticles. The assay uses only a common base and an acid, NaOH and HCl to initiate and stop the polymerization reaction, respectively, which makes the assay extremely simple and low cost. First, we studied the in situ optical properties of polydopamine nanoparticles, for the first time, which formed under different alkaline conditions in order to determine optimum experimental parameters. Then, under optimized conditions we demonstrated high sensitivity (40 nM) and excellent selectivity of the assay. With its good analytical figures of merit, the described method is very promising for detection of dopamine related diseases. D opamine (DA), a catecholamine neurotransmitter, regulates many biological processes in central nervous, hormonal, and cardiovascular systems.1,2 Abnormal DA concentrations in biological fluids (e.g., urine, blood plasma, and extracellular fluid of the central nervous system) can be indicator of several diseases such as schizophrenia and Huntington's and Parkinson's diseases. 3−5 In this regard, sensitive and selective measurement of DA levels is important for diagnosis of these diseases and monitoring of patients. 6 Common DA detection methods utilize electrochemical analysis, 7−9 chromatography coupled with spectroscopy 10,11 (e.g., high-pressure liquid chromatography (HPLC)-fluorescence and gas chromatography/mass spectrometry (GC/MS)) and fluorescent 12−16 or colorimetric probes 1,17 (e.g., organic dyes, quantum dots, and gold nanoparticles). These methods, however, have some limitations. For instance, interference from uric acid (UA) and ascorbic acid (AA) largely limits selectivity of electrochemical methods. Chromatographic methods on the other hand, are time-consuming, labor intensive, and expensive with complicated procedures. Similarly, synthesis of fluorescent or colorimetric probes for DA detection involves complicated and time-consuming procedures.A straightforward, cost-effective and rapid alternative for DA detection is measuring the optical absorption of oxidation product of dopamine under alkaline conditions.18−22 These assays use only a common base (e.g., NaOH) or other oxidants (e.g., enzymes) as a reagent, and DA concentration is determined by simply measuring the optical absorption of the resulting brownish oxidation product. Unfortunately, the method demonstrates a poor sensitivity around a few micromolar. In these oxidation studies, the product is assumed as a quinone derivative of dopamine. 18 However, recent studies demonstrated that under alkaline conditions the quinone product is unstable and rapidly polymerized by covalent attachment and aggregation. 23−25 The resul...

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Turn-on Fluorescent Dopamine Sensing Based on in Situ Formation of Visible Light Emitting Polydopamine Nanoparticles

2014

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“…According to the previous reports, 23,35 both pH and oxidant in solution play critical roles during the self-polymerization reaction of dopamine. The typical PDA coating is achieved by immersing the substrates in bulk solution of dopamine under continuously stirring in an open environment, and the coating process would gradually cease due to the depletion of dopamine after about 12 h. 23 Thus, to deposit thicker layer of PDA film, multiple coating steps are required.…”

Section: A Modification Of Teflon Chipmentioning

confidence: 99%

“…In the static incubation method, the channels were simply loaded with pre-mixed dopamine solution and kept for certain time to generate PDA surface coating. In this scheme, potassium chlorate was doped in the solution as oxidant 35 to compensate for the deficiency of oxygen in the channel. Thicker PDA layer can thus be formed by repeating this static incubation step.…”

Section: A Modification Of Teflon Chipmentioning

confidence: 99%

Convenient surface functionalization of whole-Teflon chips with polydopamine coating

Shen

Xiong

2015

Biomicrofluidics

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This paper presents a convenient strategy to modify the surface of whole-Teflon microfluidic chips by coating the channel walls with a thin layer of polydopamine (PDA) film, which is formed by oxidation-induced self-polymerization of dopamine in alkaline solution. Two coating strategies, static incubation and dynamic flow, are demonstrated and used for tuning the physical and chemical properties of the coated channel walls. The functionalized surfaces were investigated with the contact angle, X-ray photoelectron spectroscopy, and atomic force microscopy measurements. The coating time was optimized according to the fluorescent intensity of the green fluorescent protein immobilized on the modified surface. Applications of the PDA-modified Teflon microchips in bioanalysis were demonstrated with a typical sandwich immunoassay. Moreover, long-term cell culture experiments on modified and native Teflon chips revealed that the chip biocompatibility can be greatly improved with PDA coating. The results indicate that the surface properties of the Teflon can be easily controlled by the PDA modification, thus greatly expanding the application scope of whole-Teflon chips for various chemical and biological research fields. V C 2015 AIP Publishing LLC.

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“…It is considered that poly-dopamine coating can be a versatile platform of secondary reactions for further diverse functional applications, which makes it feasible to improve the properties of materials in the biomedical fields. 6,7 Therefore, it could be a proper pretreatment and mild condition for grafting functional polymers onto metallic materials.…”

Section: Introductionmentioning

confidence: 99%

UV irradiation grafting of acrylamide onto dopamine-modified 316L stainless steel

et al. 2018

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UV irradiation grafting technique was applied on a modified 316L stainless steel (SS) surface. The SS sheets were first coated with dopamine by dipping in the dopamine solution with KIO 3 and ultrasonication. Then, the acrylamide (AAm) was grafted onto the dopamine-modified SS samples under UV irradiation with ultrasonication, when the ketonediol compound was used as a photoinitiating system. For comparison, the UV irradiation grafting of AAm was also performed without ultrasonication. The structures and morphologies of the samples were examined by Fourier transform IR spectroscopy, atomic force microscopy, and scanning electronic microscopy before and after modification, respectively. Results showed that acrylamide was successfully grafted onto the poly-dopamine-coated SS. The hydrophilicity of the modified samples improved significantly, determined by the water contact angle measurement. Shown by Tafel polarization curves, the corrosion potential of modified SS was positively shifted, which demonstrated that the corrosion resistance was improved.

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Oxidant-induced dopamine polymerization for multifunctional coatings

Cited by 658 publications

References 29 publications

Turn-on Fluorescent Dopamine Sensing Based on in Situ Formation of Visible Light Emitting Polydopamine Nanoparticles

Turn-on Fluorescent Dopamine Sensing Based on in Situ Formation of Visible Light Emitting Polydopamine Nanoparticles

Convenient surface functionalization of whole-Teflon chips with polydopamine coating

UV irradiation grafting of acrylamide onto dopamine-modified 316L stainless steel

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