Oxidant/antioxidant status in subjects with HIV infection in different clinical conditions

González-Blanco, Ivón; Calás-Hechavarria, Vianka; Gravier-Hernández, Rosario; Pérez-Correa, Daniel; Reyes-Pérez, Angélica; Hernández-Requejo, Daymé; Guevara-García, Mariela; Mir, Viviana García; Valle, Lizette Gil del; León-Fernández, Olga Sonia; Pérez-Ávila, L Jorge

doi:10.1016/j.biomag.2014.02.006

Cited by 3 publications

(5 citation statements)

References 62 publications

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“…(22) In PLHIV these comorbidities are influenced by the persistence of immune activation and inflammation. (22,23) Endothelial dysfunction, reduced availability of nitric oxide and activation of the renin-angiotensin-aldosterone system are factors involved in SAH in PLHIV. (22) Diabetes is a factor directly related to hypertension, since hyperglycemia can trigger peripheral vasoconstriction and thus lead to sodium retention.…”

Section: Resultsmentioning

confidence: 99%

Estimativa da taxa de filtração glomerular em pessoas vivendo com HIV

et al. 2019

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Resumo Objetivo Avaliar os fatores associados à estimativa da Taxa de Filtração Glomerular (eTFG) em pessoas vivendo com HIV. Métodos Estudo transversal e analítico, com avaliação de 340 pessoas em atendimento ambulatorial no município de Ribeirão Preto-SP. Calculou-se a eTFG através da fórmula Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Foi realizado análise univariada com os testes Qui-quadrado e Exato de Fisher, com p<0,05. Resultados Identificou que 114 (34,1%) dos participantes apresentaram alterações na Filtração Glomerular, dos quais (90) 27,5% foram classificadas em estágio 2, 15 (4,5%) em estágio 3A e 07 (2,1%) em estágio 3B. Conclusão O estudo evidenciou que as variáveis sexo, idade, hipertensão, diabetes, IMC e tempo de diagnóstico apresentaram associação com a Taxa de Filtração Glomerular. Ressalta-se a importância do acompanhamento integral de PVHIV para a tomada de decisões de modo a prevenir a ocorrência de disfunções renais.

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Section: Resultsmentioning

confidence: 99%

Estimativa da taxa de filtração glomerular em pessoas vivendo com HIV

et al. 2019

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“…However there are controversial data on this marker in literature. While some authors [29] showed no differences between HIV-infected or uninfected, symptomatic or asymptomatic patients, others [14, 30] have found higher MDA concentration in infected patients with low CD4+ T counts.…”

Section: Discussionmentioning

confidence: 99%

“…One of the explanations for low TAC in PLWHA would be the high consumption of antioxidants due to high levels of ROS presented by this population [14]. The other would be the lack of antioxidant intake and of their precursors and/or the poor absorption of nutrients resulting from the changes in intestinal homeostasis [14, 38].…”

Section: Discussionmentioning

confidence: 99%

“…The other would be the lack of antioxidant intake and of their precursors and/or the poor absorption of nutrients resulting from the changes in intestinal homeostasis [14, 38]. Aspects related to dietary surveys and clinical manifestations suggestive of the malabsorption syndrome were not assessed in this study; thus comparisons were not possible.…”

Section: Discussionmentioning

confidence: 99%

“…The literature points out that lipid peroxidation, as measured, for example, by serum analysis of malondialdehyde (MDA) [13, 14] and 8-isoprostanes [6, 15], is higher in PLWHA, compared to noninfected individuals [13, 14], and it increases following cART initiation [6, 15]. In addition, a recent study with these markers has shown that oxidative stress was a predictor of all-cause mortality in HIV-infected patients, and, for F2-isoprostane, this association is independent of HIV-related factors and subclinical inflammation [16].…”

Section: Introductionmentioning

confidence: 99%

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Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV‐Infected Individuals: A Longitudinal Study

Tasca

Caleffi

Corrêa

et al. 2017

Oxidative Medicine and Cellular Longevity

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Background. The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidative stress parameters. This is a longitudinal study including 30 asymptomatic patients divided according to their CD4+ T cell count (G1: <500 cell/mL; G2: >500 cell/mL) before (M0) and after (M1) cART initiation. We analyzed total antioxidant capacity (TAC), fat-soluble vitamins, malondialdehyde, 8-isoprostane, and DNA damage. Results. Results showed a decrease in TAC, retinol, α-tocopherol, and some carotenoids, in addition to a significant increase in DNA damage at M1. These changes were more evident in G2 subjects. Moreover, there was a significant 8-isoprostane increase at M1 in individuals belonging to G1. Conclusion. The results indicate that cART interfered in the redox system, mainly by reducing the antioxidant defenses. In addition, patients who had CD4+ T counts higher than 500 cells/mm3 showed more susceptibility to genotoxicity, while patients with less CD4+ T counts displayed more damage triggered by lipoperoxidation. Considering the early beginning of cART, its chronic use, and its capacity to alter the redox status, further long-term studies on larger cohorts are needed to define the best time to initiate therapy and to investigate new strategies to delay the development of non-AIDS diseases.

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Redox imbalance is related to HIV and pregnancy

et al. 2021

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Redox imbalance may compromise the homeostasis of physiological processes indispensable to gestational development in HIV-infected women. The present study aims to evaluate markers of the redox system in the development of pregnancy of these women. HIV-positive pregnant women, HIV-negative pregnant women and non-pregnant were studied. Redox markers superoxide dismutase (SOD), catalase (CAT), protein carbonylation and malondialdehyde (MDA) were assessed at first or second trimester, third trimester and postpartum from pregnant and from non-pregnant women. According to the longitudinal analysis model, CAT activity was increased in the postpartum in HIV-positive women and before delivery in HIV-negative women. Increased carbonylation was observed in the pre-delivery period of HIV-negative pregnant women and MDA concentrations were higher in HIV-positive pregnant women compared to those non-infected by HIV at all times. According to the factorial model, higher SOD and CAT activities were observed in HIV-positive women in the initial months of pregnancy and in non-pregnant women. Carbonylation at third trimester was more evident in HIV-negative pregnant women. MDA levels were higher in HIV-positive pregnant women. Increased oxidative stress may occur in HIV-infected pregnant women. Nevertheless, the HIV virus is not solely responsible for this process; instead, mechanisms inherent to the pregnancy seem to play a role in this imbalance.

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Oxidant/antioxidant status in subjects with HIV infection in different clinical conditions

Cited by 3 publications

References 62 publications

Estimativa da taxa de filtração glomerular em pessoas vivendo com HIV

Estimativa da taxa de filtração glomerular em pessoas vivendo com HIV

Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV‐Infected Individuals: A Longitudinal Study

Redox imbalance is related to HIV and pregnancy

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