Oxidant-antioxidant status in patients with oral squamous cell carcinomas at different intraoral sites

Rajamanickam, Subapriya; Ramasamy, Kumaraguruparan; Ramachandran, C. R.; Nagini, Siddavaram

doi:10.1016/s0009-9120(02)00340-5

Cited by 72 publications

(66 citation statements)

References 20 publications

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“…Such results have been reported in breast cancer patients also [17]. Similar statistically significant MDA levels were observed in tissue samples which is in contrast to many studies [13,18,19] wherein the inverse relationship of TBARS to tumour progression was attributed to cellular proliferation [13], decreased concentration of free fatty acids In tumour tissue and decreased levels of phospholipids [18]. However, in the present study, the positive correlation between TBARS and tumour tissue as compared to normal mucosa could be attributed to greater cyclooxygenase activity resulting from inflammatory mediators involved in tumour progression [20].…”

Section: Discussionsupporting

confidence: 88%

“…The control values of mean lipid peroxides in tissue were 0.59±0. 13 and the values were increased in patients with leukoplakia as 0.79±0.09 which was also statistically significant (p<0.0001).…”

Section: Study Group A-leukoplakiamentioning

confidence: 60%

“…Continuous exposure to carcinogenic benzopyrene and nitrosamine present in tobacco and areca nut predisposes the mucosal surface to malignant transformation. Tobacco smoking has been reported to stimulate H 2 O 2 and hydroxyl radicals and chewing of betel quid with generate DNA maging oxygen free radicals causing chromosomal damage [13]. In the present study, patients with oral pre-cancer(oral leukoplakia) has been taken as oral leukoplakia is the best known precursor lesion and most common potentially transforming malignant lesion of the oral cavity.…”

Section: Discussionmentioning

confidence: 95%

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Assessment of Lipid Peroxides in Multiple Biofluids of Leukoplakia and Oral Squamous Cell Carcinoma Patients- A Clinico- Biochemical Study

Ganesan

Kumar²

2014

JCDR

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Background: Oral pre cancer and oral cancer results in lipid peroxidation, and assessment of lipid peroxides in body fluids may give insights into the role of anti oxidants in its management. Aim:The study was conducted to discern the varying levels of lipid peroxides in saliva, serum and tissue in oral pre cancer and oral cancer and also various forms of tobacco usage with sex as an added parameter. Materials and Methods:The levels of lipid peroxides were measured in saliva, serum and tissue in a total of 50 patients, 20 belonging to control, and 30 study group in which 10 with oral leukoplakia and 20 with histologically proven oral squamous cell carcinoma (OSCC). The mean value of malondialdehyde (MDA) were also recorded in males and females among the patients with oral leukoplakia and OSCC. Among the study group patients, the levels of MDA were also recorded in habits of smoking and chewing tobacco. Statistical analysis used:Student's independent t-test, one way ANOVA, Tukey HSD procedure.Results: Significantly elevated levels of lipid peroxides were seen in saliva, serum and tissue in oral leukoplakia and OSCC when compared to control patients. Among the study group, there were statistically significant increased levels of MDA in OSCC when compared to oral leukoplakia. There was also increase in MDA level in patients with smoking and chewing, but the variations seen in males and females were not very significant. Conclusion:The results clearly indicate the increase in lipid peroxidation in oral pre cancer and oral cancer with no significant difference between gender groups. The role of saliva as a relatively risk free and reliable, easy to obtain biofuid for diagnostic purposes has been highlighted. Also, since the levels of antioxidants are drastically decreased in carcinogenesis, the importance of anti oxidant supplements in the early stages of the disease has also been elucidated.

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Section: Discussionsupporting

confidence: 88%

Section: Study Group A-leukoplakiamentioning

confidence: 60%

Section: Discussionmentioning

confidence: 95%

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Assessment of Lipid Peroxides in Multiple Biofluids of Leukoplakia and Oral Squamous Cell Carcinoma Patients- A Clinico- Biochemical Study

Ganesan

Kumar²

2014

JCDR

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“…Heba et al [11] also reported that rats fed with powder of Ziziphus spina-christi fruit decrease the activities of AST, ALT, and ALP in CCl 4 induced rats in a dose-dependent manner. A similar significant increase in the activity of AST in the serum of ELA induced mice was reported by Nalini et al [12].…”

Section: Discussionsupporting

confidence: 87%

Anticancer Activity of Plant Protein Against Dalton’s Lymphoma Ascites Tumor Cell Lines

Srilatha¹,

Santhi²,

Annapurani³

2016

Asian J Pharm Clin Res

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Objective: Tabernaemontana divaricata (Td) is commonly used plants for the treatment of inflammatory, anticancer, and diabetics. The main objective of this study is to assess the antitumor and antioxidant activity of Td in mice model. Methods:Antitumor activity of TdPf extract (52 µg/ml) is evaluated against Dalton's lymphoma ascites (DLA) tumor mice. After 24 hrs of tumor inoculation, the extract is administered daily for 15 and 60 days. After administration of the lost dose followed by 18 hrs fasting, mice are sacrificed for observation of antitumor activity. Antitumor activity is assessed by monitoring the liver marker enzyme, lipid peroxidation effect on antioxidant enzyme levels, and histopathological evidence. Results:The results showed that the protein extract of Td animals restored the antioxidant enzymes when compared to the mice of the DLA control group. Conclusion:The findings indicate that the extract of plant protein has antitumor activity by preventing the lipid peroxidation and thereby promoting the antioxidant systems in DLA induced mice. And hence, it is evident that these extract could be a natural anticancer agent for the human health.

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“…However, there is scant medical literature on this subject. Although a few earlier studies have demonstrated the status of lipid peroxidation and antioxidant defense mechanism in plasma and erythrocytes of oral cancer [7][8][9][10], there are no reports on lipid peroxidation and antioxidant therapy in patients with leukoplakia in a specific sub-group of tobacco abusers. Against this background, a prospective study with control was carried out in tobacco abusers:…”

Section: Introductionmentioning

confidence: 99%

Role of Measurement of Antioxidant Enzymes in Evaluation of Antioxidant Therapy in Tobacco Abusers with Oral Leukoplakia

Jain

Singh

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Antioxidants are widely used in chemoprevention of malignancy. Numerous studies in medical literature have reported the evaluation of this treatment protocol by indirect methodology-epidemiology, invitro studies, pharmacology and animal models etc. However, there is a paucity of literature on the measurement of antioxidant enzymes as a parameter for assessing the outcome of antioxidant therapy. This study explores the efficacy and outcome of antioxidant enzyme assay in relation to antioxidant therapy in tobacco abusers, hitherto unreported in medical literature. A prospective cohort study with control in 50 patients carried out at a tertiary care teaching Institution (Institute of Medical Sciences, Banaras Hindu University, Varanasi, India). Out of these patients, 10 patients acted as control, rest 40 patients-all tobacco users in some form, were divided into three groups on the basis of histopathological grading of dysplasia-no dysplasia, mild or moderate dysplasia. The levels of Lipid peroxidase (LPO), Superoxide dismutase (SOD) and Catalase (CAT) in mucosa and serum were assayed in each group, and re-evaluated at the end of 3 months after intervention with antioxidant treatment. To detect any alteration in degree of dysplasia a repeat biopsy was also done at the end of 3 months. The results were statistically analysed using paired t test. A statistically significant decrease in level of LPO and SOD, and an increase in CAT levels were recorded both in mucosa and serum. However, no change in dysplasia and no new case of dysplasia were observed. Further, antioxidant treatment was continued for a year and the final out come of the lesion was assessed by ''Carter's criteria''. A final success rate of 74.19% was recorded in terms of partial or complete regression of the lesion. This study confirms the therapeutic efficacy of antioxidants in oral leukoplakia, and cites the importance of LPO, SOD and CAT in evaluating the efficacy of antioxidant treatment. However, the study failed to elucidate any relationship between enzyme measurement and the final outcome of the lesion.

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Oxidant-antioxidant status in patients with oral squamous cell carcinomas at different intraoral sites

Cited by 72 publications

References 20 publications

Assessment of Lipid Peroxides in Multiple Biofluids of Leukoplakia and Oral Squamous Cell Carcinoma Patients- A Clinico- Biochemical Study

Assessment of Lipid Peroxides in Multiple Biofluids of Leukoplakia and Oral Squamous Cell Carcinoma Patients- A Clinico- Biochemical Study

Anticancer Activity of Plant Protein Against Dalton’s Lymphoma Ascites Tumor Cell Lines

Role of Measurement of Antioxidant Enzymes in Evaluation of Antioxidant Therapy in Tobacco Abusers with Oral Leukoplakia

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