Oxidant and antioxidant activities in childhood meningitis

Tsukahara, Hirokazu; Haruta, T; Todoroki, Yukiko; Hiraoka, Masahiro; Noiri, Eisei; Maeda, Masayuki; Mayumi, Mitsufumi

doi:10.1016/s0024-3205(02)02137-9

Cited by 37 publications

(24 citation statements)

References 34 publications

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“…We verified a significant increase of TBARS levels in the CSF of meningitis patients, indicating that lipid peroxidation was stimulated in both meningitis types. The results of the present study are in agreement with those obtained by Tsukahara et al [37] that observed enhance in oxidant activities in the CNS of children with early bacterial meningitis. Similarly, Koedel and Pfizer [38] observed markers elevation for lipid peroxidation in the CSF of patients with bacterial meningitis, however this elevation has not been observed in patients with aseptic meningitis.…”

Section: Discussionsupporting

confidence: 94%

Oxidative Stress in Cerebrospinal Fluid of Patients with Aseptic and Bacterial Meningitis

et al. 2009

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This study aimed to determine whether patients with aseptic and bacterial meningitis presented alterations in oxidative stress parameters of cerebrospinal fluid (CSF). A total of 30 patients were used in the research. The CSF oxidative stress status has been evaluated through many parameters, such as lipid peroxidation through thiobarbituric acid reactive substances (TBARS) and antioxidant defense systems such as superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and ascorbic acid. TBARS levels, SOD and GST activity increase in aseptic meningitis and in bacterial meningitis. The ascorbic acid concentration increased significantly in patients with both meningitis types. The reduced glutathione levels were reduced in CSF of patients with aseptic and bacterial meningitis. In present study we may conclude that oxidative stress contributes at least in part to the severe neurological dysfunction found in meningitis.

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Section: Discussionsupporting

confidence: 94%

Oxidative Stress in Cerebrospinal Fluid of Patients with Aseptic and Bacterial Meningitis

et al. 2009

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“…Christen et al (2001) have demonstrated that bacterial meningitis of infant rats is accompanied by oxidative stress in the brain parenchyma. In the study of Tsukahara et al (2002) data indicate the enhancement of both oxidant and antioxidant activities in the central nervous system of children with early bacterial meningitis, but not in those with aseptic meningitis. Additionally, sensorineural hearing loss following acute bacterial meningitis could be caused by hydroxyl radicals generated by the inflammatory response (Maurizi, 1999).…”

Section: Discussionmentioning

confidence: 92%

Brief Clinical Report: EVALUATION OF ANTIOXIDANT STATUS IN CHILDREN WITH ACUTE BACTERIAL MENINGITIS AND ENCEPHALITIS

Çaksen

Dede

Cemek

et al. 2003

International Journal of Neuroscience

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Antioxidant status was investigated in children with acute bacterial meningitis and encephalitis to investigate the possible role of free radicals in children with meningitis and encephalitis. Our study included 16 children with acute bacterial meningitis, 13 with encephalitis, and 17 control subjects. Serum ceruloplasmin, uric acid, albumin, bilirubin superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were studied in all subjects within 6 h of admission. There was a statistically significant difference between the groups for all parameters except for serum uric acid. All antioxidant activities except for albumin level were increased in the study groups. Albumin level was higher in the control group than those of meningitis and encephalitis groups. When the values of meningitis and encephalitis were compared, there was a statistically significant difference between the groups for serum SOD, GPx, ceruloplasmin, and albumin. In conclusion, our study showed that serum SOD, GPx, catalase, and ceruloplasmin were higher in children with acute bacterial meningitis and serum SOD, GPx, catalase, ceruloplasmin, and total bilirubin levels were increased in children with encephalitis. These findings suggest that antioxidant status was almost similar in both acute bacterial meningitis and encephalitis conditions in childhood.

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“…Bilirubin levels could actually serve as a biomarker for a number of non-hepatic disease states (Table 3). Parkinson's disease [157] Multiple sclerosis [130] Schizophrenia [73,130] Cancer [84,119] Cardiovascular disease [58,59] Arthritis [158] Nitrosative stress [28] Alzheimer's disease [49,55] Parkinson's disease [157] Schizophrenia [82,130,159] Trauma [50,51] Bacterial meningitis [160] Human cerebral malaria [85] Friedreich's ataxia [149] Amyotrophic lateral sclerosis [135] Ischemia-reperfusion Injury [96,97] Multiple sclerosis [117] Cancer [84,119] Carotid plaques [58] Cardiovascular disease [43] Artherosclerosis [60,136] Atopic dermatitis [62] Rheumatoid arthritis [158] Diabetes [44,161] Asthma [162] Transplantation [116] Brought to you by | New York University Bobst Library Technical Services Authenticated Download Date | 7/27/15 12:52 PM Bilirubin appears as a potential candidate for increasing both graft tolerance and long-term graft survival by maintaining cell viability and controlling inflammation thanks to its anti-apoptotic and anti-inflammatory properties. Quite expectedly, heme oxygenase-1, the rate-limiting enzyme in bilirubin synthesis, is upregulated at the sites of inflammation and that the stimulated activity of this e...…”

Section: Resultsmentioning

confidence: 99%

The pharmacological features of bilirubin: the question of the century

Zahir

Rabbani

Khan

et al. 2015

Cellular and Molecular Biology Letters

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This review looks at the toxicity and metabolism of bilirubin in terms of its pharmacological potential. Its role has gained importance as more research has revealed the functional significance and interrelationship between the gasotransmitters nitric oxide and carbon monoxide. The biological actions of bilirubin have mostly been characterized in the high micromolar range where toxic effects occur. However, it could also prove to be an important cytoprotector for brain tissue, which is inherently less equipped for antioxidant defense. Plasma bilirubin levels negatively correlate to a number of disease states. Higher levels of bilirubin that are still within the normal range provide a protective effect to the body. The effects on various disorders could be tested using controlled pharmacological upregulation of the molecule with animal models. At nanomolar concentrations, considerable benefits have been obtained when the molecule was delivered pharmacologically under in vitro or in vivo test conditions, particularly in neurodegenerative disorders and after tissue or organ transplantation. The induction of heme oxygenase-1 (HMOX-1) via the activation of nuclear factor erythroid 2-related factor or the use of bile pigments in the harvesting of diseased tissue are novel applications, and like every new therapy, should be used with caution. HMOX-1 is tissue specific, and in exceptional states, such as schizophrenia and specific types of renal disorder, the same therapy may have disastrous effects.

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Oxidant and antioxidant activities in childhood meningitis

Cited by 37 publications

References 34 publications

Oxidative Stress in Cerebrospinal Fluid of Patients with Aseptic and Bacterial Meningitis

Oxidative Stress in Cerebrospinal Fluid of Patients with Aseptic and Bacterial Meningitis

Brief Clinical Report: EVALUATION OF ANTIOXIDANT STATUS IN CHILDREN WITH ACUTE BACTERIAL MENINGITIS AND ENCEPHALITIS

The pharmacological features of bilirubin: the question of the century

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