In the context of deep geological disposal of high level radioactive wastes, the French National Modeling of mechanical parameters such as shear modulus, young modulus, bulk modulus indicates weak variability of these parameters which confirm the homogeneity of the Callovo-Oxfordian clay. 3D modeling of a permeability index (Ik-Seis) computed from seismic attributes (instantaneous frequency, envelope, elastic impedance) and validated at the reference borehole shows promising potential for supporting hydrogeological simulation.