Oxford Handbook of Respiratory Medicine

Bleomycin-induced pneumonitis in a young Ghanaian male with Hodgkin’s Lymphoma

“…9,0 Empirical treatment for PJP is encouraged in such immunosuppressed patients while awaiting confirmatory tests especially where pneumocystis silver stains of BAL or sputum can remain posi-tive10 -14 days after treatment initiation. 13,17,18 Elevated serum LDH levels also occur in PJP infections and could be an important marker of the disease in HIV infected individuals but less so in non-HIV immunosuppressed cases where the underlying malignancy could drive the increased levels of LDH making interpretation unclear as seen in our case report. 19 LDH however is a non-specific indicator of organ damage and may be elevated in variety of lung diseases/infections.…”

Prediction of tumour pathological subtype from genomic profile using sparse logistic regression with random effects

“…Our main interest in this study is to investigate statistical models to predict two different subtypes in lung cancer: squamous carcinoma (SC) and adenocarcinoma (AC) [20]. In the context of cancer patients' care and well-being management, identification of the correct pathological subtype is critical as the treatment administered to them depends on the subtype [2,4]. Each tumour subtype has different patterns of CNA because the underlying process of their development is different due to the origin of cancer [13].…”

Lung Cancer: Risk Factors, Management, And Prognosis

“…The rates in Africa and South Asia are much lower [3].Worldwide in 2012,lung cancer occurred in 1.8 million people and resulted in 1.6 million deaths [4].This makes it the most common cause of cancer related death in men and second most common in women after breast cancer [5].Malaysian National Cancer Registry(2007) ,reported 1865 lung cancer cases with male 70.8% and female 29.2% [6].Contributory factors include long-term tobacco smoking(85%) [1],10 to 15% of cases occurred in people who have never smoked [7].These cases are often caused by a combination of factors and exposure to random gas, asbestos, second-hand smoke, or other forms of air pollution [8].The two main types of(cancer) are small -cell lung carcinoma(SCLC) and non-small-cell lung carcinoma(NSCLC) [9].The most common clinical manifestations are coughing (including coughing of blood),weight loss, shortness of breath and chest pain [10].Diagnosis mainly by chest radiographs and computed tomography(CT)scans [1].The diagnosis is confirmed with biopsy by bronchoscopy or CT-guidance [11].Common treatment include surgery, chemotherapy, and radiography [1]NSCLC is sometimes treated with surgery, whereas SCLC usually respond to chemotherapy and radiotherapy [12].Prevention by avoiding risk factors including smoking and air pollution [13].The paper describes current literature, risk factors, and management of lung cancer.…”