Oxcarbazepine treatment in male epilepsy patients improves pre-existing sexual dysfunction

Luef, Gerhard; Stefan, H.

doi:10.1111/j.1600-0404.2008.01085.x

Cited by 27 publications

(13 citation statements)

References 30 publications

(39 reference statements)

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“…Due to the natural effect of AEDs is to control the seizure symptoms of the patients, it seems that the more sedative AEDs have a greater impact on the sexual functioning than those AEDs with less sedative effects [46]. Intriguingly, some clinicians found that oxcarbazepine (a keto-derivative of carbamazepine) not only had the beneficial effects on SD, but also was effective for well control in PWE [48]. In line with this finding, Atarodi-Kashani et al reported that non-enzyme-inducing AEDs (i.e., Lamotrigine and Levetiracetam) could significantly improve the desire, orgasm, and satisfaction [30].…”

Section: Discussionmentioning

confidence: 99%

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Zhao

Tang

Xie

et al. 2019

Seizure

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A B S T R A C TPurpose: Sexual functioning is an important factor influencing quality of life. Mounting evidence suggests that both male and female patients with epilepsy (PWE) have an increased risk of developing sexual dysfunction (SD). The aim of this meta-analysis was to quantify the association between epilepsy and the risk of SD. Methods: PubMed, Embase, and Cochrane Library database were systematically searched to identify the pertinent studies focusing on the association between epilepsy and SD. Relative risk (RR) for SD with 95% confidence interval (CI) was calculated. The overall quality of the evidence was generated by applying the GRADE-profiler. This meta-analysis was registered on the PROSPERO (ID: CRD42018103572, http://www.crd.york.ac.uk/ PROSPERO). Results: Nine studies (3 cross-sectional, 5 case-control, and 1 cohort) were included in this meta-analysis, for a total of 1556 subjects and 599 cases of epilepsy. Synthetic results demonstrated that epilepsy was associated with an increased risk of female SD (6 studies, pooled RR = 2.69, 95%CI: 1.48-4.89, P = 0.001; heterogeneity: I 2 = 88.9%, P < 0.001) as well as male SD (3 studies, pooled RR = 4.85, 95%CI: 2.01-11.7, P < 0.001; heterogeneity: I 2 = 74.2%, P = 0.021). The GRADE-profiler showed that the rate of events of SD on average in the PWE and the controls were 383/659 (58.1%) and 168/1017 (16.5%), respectively. The quality of evidence across outcomes was MODERATE. Conclusions: Epilepsy is significantly associated with an increased risk of SD in both sexes. These findings suggest that both clinicians and patients should recognize that epilepsy has a potential hazardous effect on sexual functioning.

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Section: Discussionmentioning

confidence: 99%

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Zhao

Tang

Xie

et al. 2019

Seizure

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“…Studies have investigated the effects of seizures themselves and some older antiepileptic drugs (AEDs; carbamazepine [CBZ], phenobarbital [PB], phenytoin [PHT], and valproic acid [VPA]) on the reproductive and sexual function of male patients with epilepsy . There have been relatively few studies of newer AEDs (oxcarbazepine [OXC], levetiracetam [LEV], or lamotrigine [LTG]), and some of them are controversial . In this study, newly diagnosed male adult patients with epilepsy were randomized to receive OXC, LEV, or LTG monotherapy to observe the quality of semen, sexual function, and sex hormones before and after treatment, and to explore the effects of these AEDs on the reproductive and sexual functions of male adult patients with epilepsy.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] There have been relatively few studies of newer AEDs (oxcarbazepine [OXC], levetiracetam [LEV], or lamotrigine [LTG]), and some of them are controversial. 6,7 In this study, newly diagnosed male adult patients with epilepsy were randomized to receive OXC, LEV, or LTG monotherapy to observe the quality of semen, sexual function, and sex hormones before and after treatment, and to explore the effects of these AEDs on the reproductive and sexual functions of male adult patients with epilepsy.…”

Section: Introductionmentioning

confidence: 99%

The effects of oxcarbazepine, levetiracetam, and lamotrigine on semen quality, sexual function, and sex hormones in male adults with epilepsy

Chen

Ji³

et al. 2018

Epilepsia

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“…More safe therapies seem to rely on second-generation AEDs, like oxcarbazepine (OCX), gabapentin (GBP), levetiracetam (LEV) and lamotrigine (LTG). Although their influence on sexual functions in men has not been investigated extensively as yet, some improvement of sexual functioning during treatment with these drugs was noted (Husain et al 2000; Schwartz et al 2007; Luef et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice

et al. 2012

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The aim of the present study was to investigate the effect of sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, on threshold for clonic seizures in mice. In addition, the effects of sildenafil on the anticonvulsant activity of selected antiepileptic drugs (AEDs), i.e., clonazepam (CZP), valproate (VPA), phenobarbital (PB), ethosuximide (ETS) and tiagabine (TGB), were also evaluated. The subcutaneous pentylenetetrazole (PTZ) test was used to determine the effects of sildenafil on convulsive susceptibility and the anticonvulsant activity of the studied AEDs in mice, while the acute side effects of sildenafil and its combinations with the studied AEDs were evaluated in the chimney test, step-through passive-avoidance task and grip-strength test in mice. Total brain concentrations of AEDs were also determined. Sildenafil (5–40 mg/kg) did not influence the threshold for PTZ-induced clonic seizures in mice, but increased the anticonvulsant activity of ETS in this test without any significant changes in the total brain concentration. The activity of the remaining AEDs was not significantly changed by sildenafil. Neither sildenafil alone nor its combinations with the studied AEDs produced any changes in the motor coordination, long-term memory and muscular strength in mice. Co-administration of sildenafil with ETS in male epileptic patients with co-existing erectile dysfunctions might lead to the pharmacodynamic interactions that may be beneficial for the patients. Combinations of sildenafil with CZP, VPA, PB and TGB appear to be neutral in terms of their influence on seizures.

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Oxcarbazepine treatment in male epilepsy patients improves pre-existing sexual dysfunction

Abstract: Oxcarbazepine was found to have beneficial effects on sexual dysfunction and to be effective and well tolerated in male patients with partial epilepsy.

Cited by 27 publications

References 30 publications

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

The effects of oxcarbazepine, levetiracetam, and lamotrigine on semen quality, sexual function, and sex hormones in male adults with epilepsy

Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice

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