Oxazolone-induced gastrointestinal disorders enhance the oral transmission of AA amyloidosis in mice

Abstract

Amyloid A (AA) amyloidosis is a lethal disease characterized by systemic AA amyloid deposition, and it reported in many animal species. Despite experiments have shown that AA amyloidosis can be transmitted orally, horizontal transmission and cross-species transmission are concerns, the transmission mechanism has been unknown. In this study, we examined the oral transmission efficiency of AA amyloidosis using oxazolone-induced gastrointestinal disorder mice. As a result, the upper or lower gastrointestinal disorder groups developed more severe amyloid deposition in systemic tissues than the group without gastrointestinal disorders. The results of this study suggest that gastrointestinal damage promotes the oral transmission of AA amyloidosis.

Local administration of amyloid enhancing factor initiates <i>in situ</i> amyloid A deposition followed by systemic lesions in mice

“…When AA amyloidosis is experimentally transmitted by intravenous or oral administration of AEF, the initial amyloid deposition occurs in the spleen [ 7 , 8 ]. In our previous study, gastrointestinal ulcers promoted the oral transmission of AA amyloidosis in mice [ 9 ]. However, the primary site of amyloid deposition was not the gastrointestinal tract but the spleen, irrespective of whether the ulcer was in the upper or lower gastrointestinal tract [ 9 ].…”

“…In our previous study, gastrointestinal ulcers promoted the oral transmission of AA amyloidosis in mice [ 9 ]. However, the primary site of amyloid deposition was not the gastrointestinal tract but the spleen, irrespective of whether the ulcer was in the upper or lower gastrointestinal tract [ 9 ]. These findings suggest that the spleen is an important organ for AA amyloidosis transmission.…”