Oxazole: A Promising Building Block for the Development of Potent Antitumor Agents

Abstract

Oxazole derivatives are found to have a variety of biological activities. A large number of studies have revealed their outstanding anticancer activities. Here we review four different types of oxazole derivatives with anticancer potential reported over the last ten years. We focus our discussion on their activity, selectivity in different cancer cell lines, mechanisms of action, and their structural evolution.

Iodine-Promoted Oxidative Cyclization of Methyl Azaarenes and α-Amino Ketones for One-Pot Synthesis of 2-Azaaryl-5-aryl Oxazoles

“…As a classic small-molecule five-membered heterocyclic compound, oxazole has received extensive attention in the field of medicinal chemistry in recent years due to its outstanding biological activity . The substitution pattern in oxazole derivatives plays a pivotal role in delineating biological activities .…”

1,3-Oxazol-4-ylphosphonium salts as new non-peptide inhibitors of furin

“…They were found to possess antibacterial, antifungal, anticancer, anti-inflammatory properties [14][15][16]. The heterocycle was shown to play a vital role in synthesis and manufacture of varies drugs as brainderived neurotrophic factor inducers [17], anticancer agents [18][19][20][21], antidepressants and anticonvulsants [22], compounds with antimicrobial, antiviral and antifungal activities [23][24][25][26][27][28], as well as antidiabetic [29] activity.…”