Oxathiapiprolin, a Novel Chemical Inducer Activates the Plant Disease Resistance

Peng, Qin; Wang, Zhiwen; Liu, Pengfei; Liang, Yinping; Zhao, Zhenzhen; Li, Wenhui; Liu, Xili; Xia, Ye

doi:10.3390/ijms21041223

Cited by 12 publications

(7 citation statements)

References 59 publications

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“…parasitica . This is contrary to the result of Peng Qin [ 31 ]. The reason for this discrepancy may be that the test sampling time is different, and production of reactive oxygen species under pathogen infection is reported to create oxidative stress [ 32 ].…”

Section: Discussioncontrasting

confidence: 99%

β-aminobutyric acid (BABA)-induced resistance to tobacco black shank in tobacco (Nicotiana tabacum L.)

et al. 2022

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Tobacco black shank is a kind of soil-borne disease caused by the Oomycete Phytophthora parasitica. This disease is one of the most destructive diseases to tobacco (Nicotiana tabacum L.) growth worldwide. At present, various measures have been taken to control this disease, but they still have different challenges and limitations. Studies have shown that β-aminobutyric acid (BABA), a nonprotein amino acid, can enhance disease resistance in plants against different varieties of pathogens. However, it is unclear whether BABA can induce plants to resist Phytophthora parasitica infection. Therefore, this study aims to explore the effect and related mechanism of BABA against tobacco black shank. Our results showed that 5 mmol.L-1 BABA had an obvious anti-inducing effect on the pathogenic fungus and could effectively inhibit the formation of dark spots in the stems. The results also showed that a large amount of callose deposition was observed in BABA-treated tobacco. Furthermore, the application of BABA induced the accumulation of H2O2 in tobacco and effectively regulated the homeostasis of reactive oxygen in tobacco plants, reducing the toxicity of H2O2 to plants while activating the defense system. In addition, BABA spray treatment could induce an increase in the concentrations of salicylic acid (SA) and jasmonic acid-isoleucine (JA-Ile) in tobacco, and the gene expression results confirmed that BABA upregulated the expression of SA-related genes (PR1, PR2 and PR5), JA-related genes (PDF1.2) and ET-related genes (EFE26 and ACC oxidase) in tobacco plants. Taken together, BABA could activate tobacco resistance to black shank disease by increasing H2O2 accumulation, callose deposition, plant hormone (SA and JA-Ile) production, and SA-, JA-, and ET- signaling pathways.

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Section: Discussioncontrasting

confidence: 99%

β-aminobutyric acid (BABA)-induced resistance to tobacco black shank in tobacco (Nicotiana tabacum L.)

et al. 2022

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“…Oxathiapiprolin, which has an excellent control effect on oomycetes, was developed by DuPont. It has a good inhibitory effect on a series of plant pathogens, with high activity, low dosage, and a unique mode of action 11–14 . Piperidinothiazole fungicides have rapidly become a research hotspot of oomycete disease inhibitors 15–18 .…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and fungicidal activities of novel piperazine thiazole derivatives containing oxime ether or oxime ester moieties

Peng

Tian

et al. 2023

Pest Management Science

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BACKGROUND: To study the effect of changing the piperidine ring of oxathiapiprolin on the fungicidal activity, we designed and synthesized novel piperazine thiazole derivatives containing oxime ether or oxime ester moieties, and studied their fungicidal activities against Phytophthora capsici in vitro.RESULTS: These derivatives showed moderate to good fungicidal activities against Phytophthora capsici, two oxime ether derivatives showed higher fungicidal activity in vitro than dimethomorph (EC 50 = 0.1331 ∼g mL −1 ) and comparable to oxathiapiprolin (EC 50 = 0.0042 ∼g mL −1 ). Oxime ester derivatives showed significantly reduced activities compared with oxime ether derivatives. Most of these derivatives showed broad-spectrum fungicidal activity against the other eight kinds of fungi. Moreover, four derivatives exhibited good antifungal activities in vivo against Phytophthora capsici, Pseudoperonospora cubensis, and Phytophthora infestans. The hyphae morphology study showed that compound 10d might cause mycelial abnormalities of Phytophthora capsici. CONCLUSION:The activity of 10b against Phytophthora infestans was better than that of mandipropamid, and compound 10d exhibited higher fungicidal activities against Pseudoperonospora cubensis and Phytophthora infestans than mandipropamid. These two derivatives emerged as promising candidates for antifungal drugs.

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“…Oxathiapiprolin is a new piperidine fungicide with excellent efficacy against oomycete diseases, especially those caused by pathogenic blight, and is slightly toxic at very low dosages (Pasteris et al, 2016; Peng et al, 2020). It can control oomycete diseases in grapes, potatoes, and cucumbers, among others (D'Arcangelo et al, 2021; Miao et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Physiological and biochemical regulation of tobacco by oxathiapiprolin under Phytophthora nicotianae infection

Jiao

Deng

Zhao

et al. 2023

Physiologia Plantarum

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As a fungicide, oxathiapiprolin has excellent effects on diseases caused by oomycetes. Fungicides generally protect crops by inhibiting pathogens, but little research has addressed the effects of fungicides on crops. This study combined transcriptomic and metabolomic analyses to systematically analyze the physiological regulatory mechanisms of oxathiapiprolin on tobacco under Phytophthora nicotianae infection. The results showed that under P. nicotianae infection, tobacco's photosynthetic rate and antioxidant enzyme activity increased after the application of oxathiapiprolin. Omics results showed that the genes related to carbon metabolism, disease‐resistant proteins, and amino acid synthesis were highly expressed, and the amino acid content increased in tobacco leaves. This study is the first comprehensive investigation of the physiological regulatory effects of oxathiapiprolin on tobacco in response to P. nicotianae infection. These findings provide a basis for the balance between regulating tobacco growth and development and enhancing disease resistance under the stimulation of oxathiapiprolin and provide new research and development opportunities for identifying new disease‐resistance genes and the development of high‐yielding disease‐resistant crop varieties.

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Oxathiapiprolin, a Novel Chemical Inducer Activates the Plant Disease Resistance

Cited by 12 publications

References 59 publications

β-aminobutyric acid (BABA)-induced resistance to tobacco black shank in tobacco (Nicotiana tabacum L.)

β-aminobutyric acid (BABA)-induced resistance to tobacco black shank in tobacco (Nicotiana tabacum L.)

Design, synthesis, and fungicidal activities of novel piperazine thiazole derivatives containing oxime ether or oxime ester moieties

Physiological and biochemical regulation of tobacco by oxathiapiprolin under Phytophthora nicotianae infection

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