Abstract:PURPOSE:This study is a systematic literature review and meta-analysis concerning the use of a testosterone synthetic analog, oxandrolone, and its use in severe adult burns.
METHODS:Randomized prospective clinical studies, in English, Portuguese or Spanish, were sought on the following databases:MEDLINE, COCHRANE, EMBASE and LILACS. There was no restriction in relation to the publication date.
RESULTS:This search produced 24 studies on MEDLINE and twelve articles were presented on the COCHRANE database .Sixtee… Show more
“…86 Yet, many centers still refrain from the use of oxandrolone due to previously reported risks not observed in this study. 86 As is the case with many topics related to management of burns, the meta-analysis strongly encouraged a randomized, double blind study, with a larger number of patients to obtain quality evidence for the testosterone analog.…”
Section: Lipoic Acidmentioning
confidence: 74%
“…86 As is the case with many topics related to management of burns, the meta-analysis strongly encouraged a randomized, double blind study, with a larger number of patients to obtain quality evidence for the testosterone analog. 86 Yet, with some institutions already empirically treating patients with oxandrolone before initiation of a clinical trial, a prospective trial to evaluate the effectiveness of the drug has yet to occur.…”
Section: Lipoic Acidmentioning
confidence: 99%
“…90 Although MSCs with self-renewable and multipotential properties provide a vital modality of repair and regeneration, their vitality varies according to the donor age and health condition. 75,85,86 Research in recent years has suggested that umbilical cord-derived MSCs exhibit higher occurrence of colony-forming unit fibroblast than bone marrow-derived MSCs, suggesting more primitive features. 75 …”
Section: Possible Approaches For the Futurementioning
As a result of many years of research, the intricate cellular mechanisms of burn injury are slowly becoming clear. Yet, knowledge of these cellular mechanisms and a multitude of resulting studies have often failed to translate into improved clinical treatment for burn injuries. Perhaps the most valuable information to date is the years of clinical experience and observations in the management and treatment of patients, which has contributed to a gradual improvement in reported outcomes of mortality. This review provides a discussion of the cellular mechanisms and pathways involved in burn injury, resultant systemic effects on organ systems, current management and treatment, and potential therapies that we may see implemented in the future.
“…86 Yet, many centers still refrain from the use of oxandrolone due to previously reported risks not observed in this study. 86 As is the case with many topics related to management of burns, the meta-analysis strongly encouraged a randomized, double blind study, with a larger number of patients to obtain quality evidence for the testosterone analog.…”
Section: Lipoic Acidmentioning
confidence: 74%
“…86 As is the case with many topics related to management of burns, the meta-analysis strongly encouraged a randomized, double blind study, with a larger number of patients to obtain quality evidence for the testosterone analog. 86 Yet, with some institutions already empirically treating patients with oxandrolone before initiation of a clinical trial, a prospective trial to evaluate the effectiveness of the drug has yet to occur.…”
Section: Lipoic Acidmentioning
confidence: 99%
“…90 Although MSCs with self-renewable and multipotential properties provide a vital modality of repair and regeneration, their vitality varies according to the donor age and health condition. 75,85,86 Research in recent years has suggested that umbilical cord-derived MSCs exhibit higher occurrence of colony-forming unit fibroblast than bone marrow-derived MSCs, suggesting more primitive features. 75 …”
Section: Possible Approaches For the Futurementioning
As a result of many years of research, the intricate cellular mechanisms of burn injury are slowly becoming clear. Yet, knowledge of these cellular mechanisms and a multitude of resulting studies have often failed to translate into improved clinical treatment for burn injuries. Perhaps the most valuable information to date is the years of clinical experience and observations in the management and treatment of patients, which has contributed to a gradual improvement in reported outcomes of mortality. This review provides a discussion of the cellular mechanisms and pathways involved in burn injury, resultant systemic effects on organ systems, current management and treatment, and potential therapies that we may see implemented in the future.
“…According to recommended advices for the initial care of the burn victim patient, the initial measures aim at the clinical stabilization of the patient and the simple coverage of the wounds with dry and sterile dressings allied to the treatment for pain and transfer of the patient to specialized care within the first 24 hours after clinical stabilization [8,18].…”
Section: Discussionmentioning
confidence: 99%
“…After initiation of specialized care based on the current protocols recommended [6][7][8][9][10][11][12][13][14][15]18], under the guidance of a specialist in plastic practical participation of the students. The formulations of hypotheses and questions served to fill the knowledge gaps encountered.…”
Introduction: Injuries caused by burns are responsible for a great number of absence from work, functional and aesthetic sequelae. The Problem Based Learning (PBL) consists of student-centered teaching and based on problems solution. It valorize besides the content to be learned, the form of learning, reinforcing the active role of each student in this process, allowing learning to learn.Objective: To demonstrate the process of teaching-learning used during medical school internship at Federal University of São Carlos-UFSCar, figuring as a trigger the care of a medium burn patient.
Method:The trigger used to initiate the studies was the care of a burned patient that was transferred to the General Hospital in the city of São Carlos, Brazil after first medical care at a neighbor county at Brotas, Brazil. Using active methodology-Problem Based Learning-it was accomplished a systematic literature review to guide service, and provide to the patient the most up to date knowledge.
Results:Provisional Synthesis: The importance of proper handling of a medium and critically burn patient in a general hospital to reduce morbidity and mortality was highlighted. Then, a systematic literature review was accomplished, consulting main databases, protocols to burn patient's care and electronic databases to complement the studies of inherent case served. After 21 days of burn, the patient presented a good evolution condition, with completely re-epithelialized wounds and normal laboratory parameters, with nosocomial discharge without sequelae.
Conclusion:Active learning methodology showed to be a very effective and enriching method in process of teaching-learning, bring to students not only the knowledge but also the exposure to a clinical non-controlled experience, potentializing with success, teaching and assistance.
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