Oxalosis as a complication of chronic renal failure

Salyer, William R.; Keren, David F.

doi:10.1038/ki.1973.80

Cited by 125 publications

(77 citation statements)

References 13 publications

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“…Salyer and Keren (13) found fewer deposits in patients treated by chronic hemodialysis than in those receiving peritoneal dialysis or in undialyzed patients with chronic renal failure.…”

Section: Supersaturation Measurementsmentioning

confidence: 99%

“…Blood calcium oxalate supersaturation probably is responsible for the crystals of calcium oxalate seen in kidney, myocardium, blood vessels, and other tissues (12)(13)(14)(15)(16)(17) in patients with uremia. These deposits have been associated with conduction defects (16), congestive heart failure (16,58), arthritis (14), bone disease (55), periodontal disease (17), granulomas (59), and a vasculitis-like syndrome (15).…”

Section: Supersaturation Measurementsmentioning

confidence: 99%

“…In some patients with chronic renal failure, crystals of calcium oxalate have been identified in kidney, blood vessels, myocardium, thyroid, synovia, cartilage, bone, and periodontium (12)(13)(14)(15)(16)(17). The formation of crystals indicates that calcium oxalate concentrations in these tissues must have exceeded the solubility limit on some occasions, but the mechanism by which this occurs is not clear.…”

Section: Introductionmentioning

confidence: 99%

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Evidence that serum calcium oxalate supersaturation is a consequence of oxalate retention in patients with chronic renal failure.

Worcester¹,

Nakagawa²,

Bushinsky³

et al. 1986

J. Clin. Invest.

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Serum oxalate rises in uremia because of decreased renal clearance, and crystals ofcalcium oxalate occur in the tissues of uremic patients. Crystal formation suggests that either uremic serum is supersaturated with calcium oxalate, or local oxalate production or accumulation causes regional supersaturation. To test the first alternative, we ultrafiltered uremic serum and measured supersaturation with two different methods previously used to study supersaturation in urine. First, the relative saturation ratio (RSR), the ratio of the dissolved calcium oxalate complex to the thermodynamic calcium oxalate solubility product, was estimated for 11 uremic (before and after dialysis) and 4 normal serum samples using a computer program. Mean ultrafiltrate oxalate predialysis was 89±8 ,uM/liter (±SEM), 31±4 postdialysis, and 10±3 in normals. Mean RSR was 1.7±0.1 (predialysis), 0.7±0.1 (postdialysis), and 0.2±0.1 (normal), where values >1 denote supersaturation, <1, undersaturation. Second, the concentration product ratio (CPR), the ratio of the measured calcium oxalate concentration product before to that after incubation of the sample with calcium oxalate monohydrate crystal, was measured in seven uremic and seven normal serum ultrafiltrates. Mean oxalate was 91±11 (uremic) and 8±3 (normal). Mean CPR was 1.4±0.2 (uremic) and 0.2±0.1 (normal). Predialysis, 17 of 18 uremic ultrafiltrates were supersaturated with respect to calcium oxalate. The degree of supersaturation was correlated with ultrafiltrate oxalate (RSR, r = 0.99, n = 29, P < 0.001; CPR, r = 0.75, n = 11, P < 0.001). A value of ultrafiltrate oxalate of 50 AM/liter separated undersaturated from supersaturated samples and occurred at a creatinine of -9.0 mg/dl.

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“…Salyer and Keren (13) found fewer deposits in patients treated by chronic hemodialysis than in those receiving peritoneal dialysis or in undialyzed patients with chronic renal failure.…”

Section: Supersaturation Measurementsmentioning

confidence: 99%

Section: Supersaturation Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evidence that serum calcium oxalate supersaturation is a consequence of oxalate retention in patients with chronic renal failure.

Worcester¹,

Nakagawa²,

Bushinsky³

et al. 1986

J. Clin. Invest.

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show abstract

“…Abundant deposits of calcium oxalate crystals occur in the kidney, myocardium, and bone. Intraarticular deposits and arthritis have been described in only a few patients (2)(3)(4)(5). Current knowledge of the clinical, radiographic, and crystallographic features of this newly recognized crystal-associated arthropathy is limited (5,6).…”

mentioning

confidence: 99%

Arthropathy and cutaneous calcinosis in hemodialysis oxalosis

Reginato

Seoane

Álvarez

et al. 1986

Arthritis & Rheumatism

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Recently, calcium oxalate crystals have been identified in the synovial fluid of patients with arthritis and end-stage renal failure. We describe 4 patients who, during the course of long-term hemodialysis, developed calcium oxalate crystal deposits in the synovium and skin. Clinical manifestations included podagra, tenosynovitis, olecranon bursitis, and acute and chronic synovitis of the large joints that were associated with chondrocalcinosis or subchondral bone erosions. Diffuse involvement of the hand, with chondrocalcinosis of the finger joints, miliary calcified deposits in the skin, and artery calcifications, was observed in 3 patients. The fourth patient had erosive arthropathy. Oxalosis secondary to end-stage renal failure in patients treated with long-term hemodialysis can present with articular man-

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“…By studying and comparing the occurrence of renal and myocardial oxalosis at autopsy in patients with normal renal function, acute renal failure, chronic renal failure, and chronic renal failure supported by haemodialysis or peritoneal dialysis, Salyer et al 127 found…”

Section: Kidney Transplantation and Hyperoxalaemiamentioning

confidence: 99%

Liquid chromatography–tandem mass spectrometry method for routine measurement of oxalic acid in human plasma

Elgstøen

2008

Journal of Chromatography B

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Oxalosis as a complication of chronic renal failure

Cited by 125 publications

References 13 publications

Evidence that serum calcium oxalate supersaturation is a consequence of oxalate retention in patients with chronic renal failure.

Evidence that serum calcium oxalate supersaturation is a consequence of oxalate retention in patients with chronic renal failure.

Arthropathy and cutaneous calcinosis in hemodialysis oxalosis

Liquid chromatography–tandem mass spectrometry method for routine measurement of oxalic acid in human plasma

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