Oxalosis and primary hyperoxaluria

Scowen, E. F.; Stansfeld, A. G.; Watts, R. W. E.

doi:10.1002/path.1700770119

Cited by 68 publications

(27 citation statements)

References 18 publications

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“…The most extensive renal and extra-renal deposits of calcium oxalate occur in primary hyperoxaluria (ScowE~ et al, 1959), oxalic acid or ethylene glycol poisoning (DuNN et al, 1924;Bow, 1966) and to a lesser extent in renal failure (MAc~uso and B~RG, 1959 ;FANGrR and ESrARZA, 1964). In all these conditions, the deposition of calcium oxalate appears to be due to a high concentration of oxalic acid in the body fluids and the consequent elevation of the ionic product of calcium oxalate.…”

Section: Oxalosismentioning

confidence: 98%

Oxalic acid metabolism in man: A review

Hodgkinson

Zarembski

1968

Calc. Tis Res.

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Section: Oxalosismentioning

confidence: 98%

Oxalic acid metabolism in man: A review

Hodgkinson

Zarembski

1968

Calc. Tis Res.

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“…Most often it is associated with long-standing degenerative change and as such has been described in conjunction with detached retinae (Cogan, Kuwabara, Silbert, Kern, McMurray, and Hurlbut, 1958; Zimmerman and Johnson, I958;Friedman and Charles, 1974) and cataractous lenses (Zimmerman and Johnson, 1958). According to Williams and Smith (1972), ocular involvement in primary hyperoxaluria is extremely unusual; of the two reports in the literature, one concerns a man with scanty crystals in the ciliary body detected post mortem (Scowen, Stansfeld, and Watts, 1959), and the other relates to a boy with presumed calcium oxalate crystals in the macular region of the retinae found by ophthalmoscopy (Buri, I962). Bullock, Albert, Galla, Skinner, and Miller (I973) have recently described the presence of oxalate in the pigment epithelium of the retinae of a man dying from oxalosis attributable to prolonged methoxyflurane anaesthesia, but otherwise there are no reports of the eye being implicated in secondary hyperoxaluria.…”

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confidence: 99%

Retinal oxalosis.

Garner¹

1974

British Journal of Ophthalmology

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Deposition ofcalcium oxalate crystals in the eye, though not common, is possibly not so rare as the small number of published reports would indicate. Most often it is associated with long-standing degenerative change and as such has been described in conjunction with detached retinae (Cogan, Kuwabara, Silbert, Kern, McMurray, and Hurlbut, 1958; Zimmerman and Johnson, I958;Friedman and Charles, 1974) and cataractous lenses (Zimmerman and Johnson, 1958). According to Williams and Smith (1972), ocular involvement in primary hyperoxaluria is extremely unusual; of the two reports in the literature, one concerns a man with scanty crystals in the ciliary body detected post mortem (Scowen, Stansfeld, and Watts, 1959), and the other relates to a boy with presumed calcium oxalate crystals in the macular region of the retinae found by ophthalmoscopy (Buri, I962). Bullock, Albert, Galla, Skinner, and Miller (I973) have recently described the presence of oxalate in the pigment epithelium of the retinae of a man dying from oxalosis attributable to prolonged methoxyflurane anaesthesia, but otherwise there are no reports of the eye being implicated in secondary hyperoxaluria.In the vast majority of instances oxalate deposition in the eye is, therefore, a purely ocular disturbance, the aetiology and pathogenesis of which is almost totally obscure. The object ofthe present report is to document a further case ofoxalate formation associated with retinal detachment and to discuss some of the factors which might be of aetiological significance. Case reportThe patient was a young man of Pakistani parentage who lived in Southern England.At the age of 13 years he had been hit in the eye by a foreign body composed of a hard plastic material and sustained a perforating injury to the cornea. This was complicated by secondary retinal detachment and eventually the eye become atrophic and shrunken. Pain, related to recurrent attacks of uveitis, ultimately necessitated enucleation of the now completely blind eye at the age of 2 I yrs. The remaining (right) eye was quite normal, with unimpaired vision, and there was no family history suggestive of oxalosis.Ocular pathology MACROSCOPICALThe globe was shrunken and the anterior segment was disorganized as a result of extensive scar tissue formation around a retained foreign body composed of a green and white plastic

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“…11 In another study, hyperplastic and hypertrophic RPE was observed by post mortem histopathologic examination in a primary hyperoxaluria Type 1 patient who had large black geographic submacular lesions. 7 There are many reports describing the fundus appearance and ocular histopathologic features of primary hyperoxaluria in the literature, [2][3][4][5][6][7]12,13 however, only 3 of them describe the OCT findings in oxalate retinopathy, [14][15][16] and the EDI-OCT was evaluated in only one of them. 16 Querques et al reported a 19-year-old man and showed the oxalate deposits localized within the areas of dome-shaped elevated RPE in their case using OCT.…”

Section: Discussionmentioning

confidence: 99%

“…1 In this genetic disease, calcium oxalate crystal deposition has been demonstrated in various tissues including the eyes. 2 In the eye, calcium oxalate crystal deposition was observed in the ciliary body, [3][4][5] choroid, 4 optic nerve, 4,5 all layers of the retina, 4,5 retinal arterial walls, 5 between Bruch membrane and the retinal pigment epithelium (RPE), 6 and in the RPE. 7 Optical coherence tomography (OCT) technology obtains high-resolution cross-sectional images of the retina.…”

mentioning

confidence: 99%