Oxaliplatin-induced peripheral neuropathy: clinical features, mechanisms, prevention and treatment

Kang, Lumei; Tian, Yuzhou; Xu, Shilin; Chen, Zhidong

doi:10.1007/s00415-020-09942-w

Cited by 103 publications

(97 citation statements)

References 100 publications

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“…Also, Fluorouracil (5-FU) induces increased autophagy in colon cancer cells with p53 deletion or mutation leading to increased drug resistance ( 14 ). Some scholars have studied the effect of autophagy on the efficacy of oxaliplatin and found that L-OHP can induce autophagy in CRC cells to protect CRC cells from apoptosis ( 15 ). Other studies have shown that certain drugs can exert anti-CRC effects by inducing autophagy.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Autophagy-Related Genes and lncRNAs in Therapy and Prognosis of Colorectal Cancer

et al. 2021

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Cellular autophagy plays an important role in the occurrence and development of colorectal cancer (CRC). Whether autophagy-related genes and lncRNAs can be used as ideal markers in CRC is still controversial. The purpose of this study is to identify novel treatment and prognosis markers of CRC. We downloaded transcription and clinical data of CRC from the GEO (GSE40967, GSE12954, GSE17536) and TCGA database, screened for differentially autophagy-related genes (DEAGs) and lncRNAs, constructed prognostic model, and analyzed its relationship with immune infiltration. TCGA and GEO datasets (GSE12954 and GSE17536) were used to validate the effect of the model. Oncomine database and Human Protein Atlas verified the expression of DEAGs. We obtained a total of 151 DEAGs in three verification sets collaboratively. Then we constructed a risk prognostic model through Lasso regression to obtain 15 prognostic DEAGs from the training set and verified the risk prognostic model in three verification sets. The low-risk group survived longer than the high-risk group. Age, gender, pathological stage, and TNM stage were related to the prognostic risk of CRC. On the other hand, BRAF status, RFS event, and tumor location are considered as most significant risk factors of CRC in the training set. Furthermore, we found that the immune score of the low-risk group was higher. The content of CD8 + T cells, active NK cells, macrophages M0, macrophages M1, and active dendritic cells was noted more in the high-risk group. The content of plasma cells, resting memory CD4 + T cells, resting NK cells, resting mast cells, and neutrophil cells was higher in the low-risk group. After all, the Oncomine database and immunohistochemistry verified that the expression level of most key autophagy-related genes was consistent with the results that we found. In addition, we obtained six lncRNAs co-expressed with DEAGs from the training set and found that the survival time was longer in the low-risk group. This finding was verified in the verification set and showed same trend to the results mentioned above. In the final analysis, these results indicate that autophagy-related genes and lncRNAs can be used as prognostic and therapeutic markers for CRC.

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Section: Introductionmentioning

confidence: 99%

The Effects of Autophagy-Related Genes and lncRNAs in Therapy and Prognosis of Colorectal Cancer

et al. 2021

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“…Acute oxaliplatin‐induced peripheral neuropathy (OIPN) occurs in nearly all patients, and symptoms may appear during or shortly after the first infusions. These transient symptoms are paresthesia triggered by cold and dysesthesias in the perioral region, hands, and feet 7–11 . A varied incidence of 4% to 98%, probably due to different starting doses, drug combinations, dosing intervals, and measurements, is reported 10 .…”

Section: Introductionmentioning

confidence: 99%

Qualitative Evaluation of the Influence of Acute Oxaliplatin‐Induced Peripheral Neuropathy on Quality of Life and Activities of Daily Life

et al. 2021

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Introduction/Aims Oxaliplatin often causes acute or chronic peripheral neuropathy in patients with an intestinal or pancreatic tumor, but in‐depth insights in its influence on quality of life (QoL) are lacking. We explored the influence of acute oxaliplatin‐induced peripheral neuropathy (OIPN) on daily QoL in these patients. Methods We performed semistructured interviews with a purposive sample of patients receiving oxaliplatin and possibly experiencing acute OIPN. Interviews were audio‐recorded, transcribed verbatim, and coded by two researchers. Data were analyzed by using the constant comparative method for content analysis with ATLAS.ti software. Results After nine patients, saturation took place. In total, 11 patients were interviewed. Four themes were extracted from the data: (1) adverse effects, (2) physical (un)well‐being, (3) emotional aspects, and (4) treatment aspects. All participants were suffering from acute OIPN to a certain extent, leading to restrictions in daily activities such as household chores, but also to a decrease in mobility and independency. Other adverse effects such as general malaise and gastrointestinal side effects also influenced the participants’ well‐being, as did the diagnosis and prognosis of their disease. Conclusion Acute OIPN, together with other side effects of chemotherapeutic treatment and the difficulties that come with the diagnosis of cancer and its prognosis, largely influences patients’ daily QoL. Managing expectations (by patient education) seems important.

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“…28,30,32 In 2 other studies (n = 165 patients), CHM had significant positive results after 8 treatment cycles (OR = 0.49, 95% CI = 0.24 to 1.01, P = .05; I ² = 0%; Figure 4). 25,31 CHM also showed a reduction in OIPN incidence compared with warm water bath (n = 55 patients; OR = 0.20, 95% CI = 0.06 to 0.69, P = .01) 28 or mecobalamin (n = 90 patients; OR = 0.18, 95% CI = 0.07 to 0.45, P < .01). 24 One trial (n = 44 patients) 27 compared CHM plus mecobalamin to mecobalamin, demonstrating a difference in favor of CHM plus mecobalamin after 8 and 12 treatment cycles (OR = 0.02, 95% CI = 0.00 to 0.11, P < .01, and OR = 0.23, 95% CI = 0.05 to 1.01, P = .05, respectively).…”

Section: Resultsmentioning

confidence: 90%

“…Overall, most studies reported prespecified outcomes, but only 1 study that did not report expected outcomes was deemed to be at high risk of bias. 28…”

Section: Resultsmentioning

confidence: 99%

Can External Use of Chinese Herbal Medicine Prevent Cumulative Peripheral Neuropathy Induced by Oxaliplatin? A Systematic Literature Review With Meta-analysis

et al. 2019

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Background. Peripheral neurotoxicity caused by oxaliplatin (OXA) chemotherapy is the main limitation preventing continuation of chemotherapy in patients with gastrointestinal cancer. The purpose of this study was to determine the efficacy of external use of Chinese herbal medicine (CHM) on the incidence of cumulative OXA-induced peripheral neurotoxicity (OIPN). Method. Scientific literature databases were searched to identify controlled clinical trials analyzing CHM in OIPN. Clinical studies that included at least 1 relevant primary outcome were analyzed by 2 independent reviewers. Meta-analysis was performed on the software RevMan 5.3. Results. 700 cancer patients of 9 studies were reported, of whom 352 received external CHM and 348 received warm water baths, conventional medicine, or no intervention as controls. Neurotoxicity incidence (Levi grade ≥ 1) was significantly decreased in CHM group, compared with no intervention ( P < .01). The incidence of cumulative neurotoxicity (Levi grade ≥2) was also significantly lower in the CHM group than in all the control groups ( P < .05), and the cumulative neurotoxicity in the CHM group was significantly reduced (Levi grade ≥ 3) in comparision with no intervention ( P < .01). These results were consistent with those of the subgroup analyses for preventing OIPN at each of the chemotherapy treatment cycles. There was no difference in the incidence of adverse events between groups ( P > .05). Conclusion. External use of CHM may be beneficial in preventing the OXA-induced cumulative neurotoxicity. However, given the low quality of the evidence, the results should be interpreted with caution.

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Oxaliplatin-induced peripheral neuropathy: clinical features, mechanisms, prevention and treatment

Cited by 103 publications

References 100 publications

The Effects of Autophagy-Related Genes and lncRNAs in Therapy and Prognosis of Colorectal Cancer

The Effects of Autophagy-Related Genes and lncRNAs in Therapy and Prognosis of Colorectal Cancer

Qualitative Evaluation of the Influence of Acute Oxaliplatin‐Induced Peripheral Neuropathy on Quality of Life and Activities of Daily Life

Can External Use of Chinese Herbal Medicine Prevent Cumulative Peripheral Neuropathy Induced by Oxaliplatin? A Systematic Literature Review With Meta-analysis

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