Oxaliplatin-Induced Exacerbation of Idiopathic Pulmonary Fibrosis

Abstract

INTRODUCTION: FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) is a common chemotherapy regimen for colorectal adenocarcinoma. Preliminary research demonstrated gastrointestinal, neurologic and hematologic side effects 1. Subsequent literature revealed that interstitial lung disease (ILD) occurs or is exacerbated by FOLFOX in 0 to 4.2% of cases with oxaliplatin having been established as the causative agent by process of exclusion 1,2. We now present a unique case of reversible exacerbation of Idiopathic Pulmonary Fibrosis (IPF) after administration of oxaliplatin.