“…33 , 34 Besides, irinotecan, converted to its active metabolite SN-38, had shown anti-tumor efficacy in an insular thyroid carcinoma patient (who was resistant to doxorubicin and paclitaxel) in a case report. 37 DXd, with a better anti-tumor activity than SN-38, was firstly reported to shown anti-tumor efficacy in PTC and ATC in this study. MMAE, as the most commonly used cytotoxins in nearly one-third of clinical ADCs, was membrane-permeable and could improve response rate through bystander killing effect, with an IC 50 of approximately 1 nM for all of the cell lines used.…”