Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines

Crystal structure of 2-[3,5-bis(trifluoromethyl)benzylsulfanyl]-5-(5-bromothiophen-2-yl)-1,3,4-oxadiazole, C15H7BrF6N2OS2

“…The uorine atoms of the disorderd CF 3 -group were located on a di erence Fourier map and re ned freely. chemistry as pharmacophores or auxophores possessing diverse pharmacological activities, including antibacterial [1][2][3][4][5], anticancer [6][7][8][9][10], antiviral [11][12][13], antihypertensive [14,15], anti-in ammatory [16,17] and antioxidant [18] activities. In addition, some 1,3,4-oxadiazoles are currently used as safe herbicides for crop protection [19][20][21].…”

1,2,4‐ and 1,3,4‐Oxadiazole Synthesis by Palladium‐Catalyzed Carbonylative Assembly of Aryl Bromides with Amidoximes or Hydrazides

“…In the case of 1,3,4-oxadiazoles, a widely used strategy features the dehydration of N,N'-diacylhydrazines in the last step to assemble the ring structure. [12] In 2004, a Pd-catalyzed carbonylation strategy for the assembly of N,N'-diacylhydrazines was reported by Larhed et al [13] In this work, a selection of aryl iodides was coupled to hydrazides, promoted by microwave heating and applying Mo(CO) 6 as the in situ CO source. Aryl bromides were also demonstrated to be reactive, although requiring higher reaction temperatures (130 8C), resulting in a significant yield decrease.…”

Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents

“…A number of these class of compounds act as antibacterial [1][2][3], antifungal [4][5][6], anti-inflammatory [7], analgesic [8][9][10], antituberculosis [11] and anticonvulsant agents [12][13][14]. In addition, a large number of triazole derivatives have antiulcer [15,16], antidepressant [17,18], insecticidal [19], hypolipidemic [20], antidiabetic [21] and antimitotic activity [22].…”