OXA-48 Producing <i>Klebsiella pneumoniae</i> in a Household Contact of a Previously Infected Patient: Person-to-Person Transmission or Coincidental Community Acquisition?

Yusuf, Erlangga; Huang, Te-Din; Schallier, Anneleen; Trémérie, Jean-Marie; Mertens, Rembert; Jans, Béatrice; Glupczynski, Youri; Piérard, Denis

doi:10.1089/mdr.2015.0179

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…However, this study re-asserts the central role of intra-and inter-hospital transmission for the most burdensome carbapenemase-positive clones that are already well-established within the human population. Indeed, strong links between hospital care and the acquisition of carbapenem-non-susceptible bacteria have previously been noted [14,[25][26][27][28], and the impact of community [29] or animal and environmental reservoirs [10] on clinical cases remains circumstantial. In this context, we note that a large faecal resistome analysis from slaughter pigs and broilers failed to identify carbapenemase genes in 181 pig and 178 poultry farms from nine European countries [30].…”

Section: Discussionmentioning

confidence: 99%

Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread

David¹,

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread

David¹,

et al. 2019

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“…Sporadic community-onset infection and post-travel acquisition of CPE had been reported in western countries [24-26]. In 2016 a case report in Belgium described a household acquisition of OXA-48 producing K. pneumoniae in a woman living in the same household than a patient previously infected with a similar CPE, raising the possibility of community spread in low-prevalence areas [27]. However to our knowledge, no specific prospective cross-sectional survey addressing clinical isolates in an ambulatory setting has yet been published.…”

Section: Discussionmentioning

confidence: 99%

Increasing proportion of carbapenemase-producing Enterobacteriaceae and emergence of a MCR-1 producer through a multicentric study among hospital-based and private laboratories in Belgium from September to November 2015

et al. 2017

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Carbapenemase-producing Enterobacteriaceae (CPE) strains have been increasingly reported in Belgium. We aimed to determine the proportion of CPE among Enterobacteriaceae isolated from hospitalised patients and community outpatients in Belgium in 2015. For the hospitalised patients, the results were compared to a previous similar survey performed in the same hospitals in 2012. Twenty-four hospital-based and 10 private laboratories collected prospectively 200 non-duplicated Enterobacteriaceae isolates from clinical specimens. All isolates were screened locally by carbapenem disk diffusion using European Committee on Antimicrobial Susceptibility Testing methodology. Putative CPE strains with inhibition zone diameters below the screening breakpoints were referred centrally for confirmation of carbapenemase production. From September to November 2015, we found a proportion of clinical CPE of 0.55% (26/4,705) and of 0.60% (12/1,991) among hospitalised patients and among ambulatory outpatients respectively. Klebsiella pneumoniae (26/38) and OXA-48-like carbapenemase (28/38) were the predominant species and enzyme among CPE. One OXA-48-producing Escherichia coli isolated from a hospital was found carrying plasmid-mediated MCR-1 colistin resistance. Compared with the 2012 survey, we found a significant increased proportion of clinical CPE (0.55% in 2015 vs 0.25% in 2012; p = 0.02) and an increased proportion of hospitals (13/24 in 2015 vs 8/24 in 2012) with at least one CPE detected. The study results confirmed the concerning spread of CPE including a colistin-resistant MCR-1 producer in hospitals and the establishment of CPE in the community in Belgium.

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“…4). It has been described in Algeria [65,[110][111][112][113][114], Argentina [98], Belgium [83,85,[115][116][117], Bulgaria [118], China [119], Columbia [120], Croatia [121], the Czech Republic [44], Denmark [69,122,123], Egypt [87,96], Finland [120], France [56,84,[124][125][126][127][128][129], Germany [130,131], Greece [104,132], Hungary [133], India [88,134], Iran [92,[135][136][137], Ireland [138,139], Israel [140,141], Italy [42, 142,143], Jordan [144], Kuwait [63], Leb...…”

Section: Worldwide Dissemination Of Oxa-48-like Enzymesmentioning

confidence: 99%

OXA-48-like carbapenemases producing Enterobacteriaceae in different niches

Mairi

Pantel

Sotto

et al. 2017

Eur J Clin Microbiol Infect Dis

144

115

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The emergence of carbapenem-resistant enterobacterial species poses a serious threat to public health worldwide. OXA-48-type carbapenem-hydrolyzing class D β-lactamases are widely distributed among Enterobacteriaceae, with significant geographical differences. To date, 11 OXA-48-like variants have been identified, with classical OXA-48 being the most widespread. These enzymes show high-level hydrolytic activity against penicillins and low-level hydrolysis towards carbapenems. Since the first description of the OXA-48 carbapenemase in Turkey, bacterial strains producing the enzyme have been extensively reported in nosocomial and community outbreaks in many parts of the word, particularly in the Mediterranean area and European countries. The rapid spread of Enterobacteriaceae producing OXA-48-like enzymes in different ecosystems has become a serious issue recently. The number of reservoirs for such organisms is increasing, not only in hospitals, but also in the community, among animals (e.g., livestock, companion animals, and wildlife) and in the environment. This review aims to summarize the main characteristics of the OXA-48-type carbapenemases, covering genetic and enzymatic traits, their epidemiology, clonality and associated genes, correlation with extended-spectrum β-lactamases (ESBLs) or plasmidic AmpC (pAmpC) in different bacterial species worldwide.

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OXA-48 Producing Klebsiella pneumoniae in a Household Contact of a Previously Infected Patient: Person-to-Person Transmission or Coincidental Community Acquisition?

Cited by 4 publications

References 14 publications

Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread

Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread

Increasing proportion of carbapenemase-producing Enterobacteriaceae and emergence of a MCR-1 producer through a multicentric study among hospital-based and private laboratories in Belgium from September to November 2015

OXA-48-like carbapenemases producing Enterobacteriaceae in different niches

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