OXA-23 and IS Aba1 –OXA-66 class D β-lactamases in Acinetobacter baumannii isolates from companion animals

Ewers, Christa; Klotz, Peter; Leidner, Ursula; Stamm, Ivonne; Prenger‐Berninghoff, Ellen; Göttig, Stephan; Semmler, Torsten; Scheufen, Sandra

doi:10.1016/j.ijantimicag.2016.09.033

Cited by 68 publications

(65 citation statements)

References 37 publications

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“…ST25, ST164 and ST203 have been observed in both humans (24,25) and companion animals (15,26,27), and ST149 has been isolated from human patients in Japan (25). In addition, we previously reported carbapenem-resistant Acinetobacter strains from dogs and cats in Japan (28), as has been reported for other countries (6,29). Therefore, attention should be paid to the emergence of MDR Acinetobacter spp.…”

supporting

confidence: 74%

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Species distribution, virulence factors and antimicrobial resistance of Acinetobacter spp. isolates from dogs and cats: a preliminary study

Kimura

Harada

Shimizu

et al. 2018

Microbiology and Immunology

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We investigated the prevalence of virulence factors and antimicrobial resistance among 67 Acinetobacter spp. isolates, consisting of 21 Acinetobacter baumannii and 46 non-baumannii Acinetobacter from companion animals. The PCR analysis showed that the most prevalent virulence gene was afa/draBC (29.9%), followed by papC (22.4%) and cvaC (20.9%). Antimicrobial susceptibility testing revealed that resistance to gentamicin (14.9%) and ciprofloxacin (11.9%) was relatively prevalent. Five gentamicin- and/or ciprofloxacin-resistant A. baumannii strains were assigned to ST25, ST149, ST164, ST203, and ST1198. All ciprofloxacin-resistant isolates harbored point mutations in gyrA and/or parC. This is the first preliminary monitoring of animal-origin Acinetobacter spp. in Japan.

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supporting

confidence: 74%

“…Antimicrobial-resistant Acinetobacter spp. emergence in both companion animals (2,5,6) and humans (3,7) is of great concern. Acinetobacter spp.…”

mentioning

confidence: 99%

Species distribution, virulence factors and antimicrobial resistance of Acinetobacter spp. isolates from dogs and cats: a preliminary study

Kimura

Harada

Shimizu

et al. 2018

Microbiology and Immunology

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“…However, it is important to underline that the bla OXA-23 and bla OXA-51 -like genes may be naturally occurring in A. baumannii [163]. On the other hand, the studies in companion animals have reported A. baumannii isolates genetically similar to the nosocomial European (also called International) clones I, II and III, suggesting its spread from humans to animals directly or via the environment [159,160,164,165]. …”

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

“…The bla OXA-23 is a wide distributed carbapenemase gene in A. baumannii isolates, which has been described recently in livestock and/or pets [151,153,154,159,165]. The bla OXA-23 gene has also been found in A. lwoffi from poultry [154].…”

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

et al. 2017

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Antimicrobial agents are used in both veterinary and human medicine. The intensive use of antimicrobials in animals may promote the fixation of antimicrobial resistance genes in bacteria, which may be zoonotic or capable to transfer these genes to human-adapted pathogens or to human gut microbiota via direct contact, food or the environment. This review summarizes the current knowledge of the use of antimicrobial agents in animal health and explores the role of bacteria from animals as a pool of antimicrobial resistance genes for human bacteria. This review focused in relevant examples within the ESC(K)APE (Enterococcus faecium, Staphylococcus aureus, Clostridium difficile (Klebsiella pneumoniae), Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae) group of bacterial pathogens that are the leading cause of nosocomial infections throughout the world.

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“…Another useful marker is the class 1 integron, involved in acquisition of resistance, frequently present in ‘outbreak’ strains of A. baumannii . A previous study found that companion animals in veterinary clinics shared the same clonal lineages of A. baumannii and carried the same carbapenem resistance determinants as those from humans …”

Section: Introductionmentioning

confidence: 99%