2023
DOI: 10.1016/j.clim.2023.109637
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OX40 shapes an inflamed tumor immune microenvironment and predicts response to immunochemotherapy in diffuse large B-cell lymphoma

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Cited by 5 publications
(2 citation statements)
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“…DLBCL is the most common subtype of aggressive lymphoma with certain patients who cannot benefit from the current treatment [ 2 ], and novel therapeutic targets were needed to explore. The disorder of TME plays a vital role in the development and metastasis of DLBCL [ 5 , 6 ], among which CD8 + TILs are indispensable for tumor eradication and prognosis evaluation [ 7 , 8 ]. Recently, Zhao et al demonstrated the exhaustion status of CD8 + TILs in DLBCL and constructed a prognostic model based on the associated genes [ 23 ].…”
Section: Discussionmentioning
confidence: 99%
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“…DLBCL is the most common subtype of aggressive lymphoma with certain patients who cannot benefit from the current treatment [ 2 ], and novel therapeutic targets were needed to explore. The disorder of TME plays a vital role in the development and metastasis of DLBCL [ 5 , 6 ], among which CD8 + TILs are indispensable for tumor eradication and prognosis evaluation [ 7 , 8 ]. Recently, Zhao et al demonstrated the exhaustion status of CD8 + TILs in DLBCL and constructed a prognostic model based on the associated genes [ 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…TILs are crucial members of TME in DLBCL, in which CD8 + TILs are the main components that deliver anti-tumor immune response [ 7 , 8 ]. We previously analyzed the characteristics of TME in DLBCL by flow cytometry and found that CD8 + TILs may be an important cause of the heterogeneity in DLBCL [ 9 ], and the proportion of CD8 + TILs and the expression of PD-1 play a pivotal role in prognosis evaluation [ 10 ].…”
Section: Introductionmentioning
confidence: 99%