OX40 expressed in endothelial cells facilitates tumor cells to escape from T-cell surveillance through S1P-YAP axis
Bin Zhang,
Baoyu He,
Rou Zhao
et al.
Abstract:Activation of immune cells is currently one of the most promising approaches for the cancer treatment. However, clinical trials for T-cell activation therapy have not reached expected results without explicit reasons. In the present study, we report that the co-stimulatory molecule OX40 is highly expressed in endothelial cells (ECs) of tumor tissues. Clinically, high expression of OX40 in ECs is negatively associated with the prognosis of tumor patients, and this is irrelevant to T-cell activation or not. Anal… Show more
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