Owner's Perception of Seizure Detection Devices in Idiopathic Epileptic Dogs

Bongers, Jos; Gutierrez‐Quintana, Rodrigo; Stalin, Catherine

doi:10.3389/fvets.2021.792647

Cited by 6 publications

(10 citation statements)

References 32 publications

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“…The SDS can have several benefits in veterinary medicine. Numerous studies showed that the caregivers of epileptic dogs, particularly those who have less time to supervise the dog directly, experience stress and anxiety due to unpredictable seizures ( 2 , 4 , 6 ). Medical staff may have a similar experience because continuous monitoring is not always easy in some busy clinics.…”

Section: Discussionmentioning

confidence: 99%

“…A seizure detection system (SDS) that can be used for continuous monitoring and the detection and notification of seizures can reduce burden among owners and veterinarians. Based on a recent study, the owners of dogs with epilepsy want to use a seizure detection device ( 6 ). Such a system can accurately identify seizure frequency, which is important for the medical/surgical treatment of epilepsy.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Generalized Tonic–Clonic Seizures in Dogs With a Seizure Detection System Established Using Acceleration Data and the Mahalanobis Distance: A Preliminary Study

Hirashima

Saito

et al. 2022

Front. Vet. Sci.

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Caregivers of dogs with epilepsy experience severe stress due to unpredictable seizures. Hence, they feel the need for a better management strategy. A seizure detection system (SDS), which can identify seizures and provide notifications to caregivers immediately, is required to address this issue. The current study aimed to establish a wearable automatic SDS using acceleration data and the Mahalanobis distance and to preliminarily investigate its feasibility among dogs. A generalized tonic–clonic seizure (GTCS) was targeted because it is the most common type of seizure and can have serious consequences (i.e., status epilepticus). This study comprised three phases. First, the reference datasets of epileptic and non-epileptic activities were established using acceleration data of GTCSs in 3 dogs and daily activities in 27 dogs. Second, the GTCS-detecting algorithm was created using the reference datasets and was validated using other acceleration data of GTCSs in 4 epileptic dogs and daily activities in 27 dogs. Third, a feasibility test of the SDS prototype was performed in three dogs with epilepsy. The algorithm was effective in identifying all acceleration data of GTCSs as seizures and all acceleration data of daily activities as non-seizure activities. Dogs with epilepsy were monitored with the prototype for 48–72 h, and three GTCSs were identified. The prototype detected all GTCSs accurately. A false positive finding was not obtained unless the accelerometer was displaced. Hence, a method that can detect epileptic seizures, particularly GTCSs, was established. Nevertheless, further large-scale studies must be conducted before the method can be commercialized.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of Generalized Tonic–Clonic Seizures in Dogs With a Seizure Detection System Established Using Acceleration Data and the Mahalanobis Distance: A Preliminary Study

Hirashima

Saito

et al. 2022

Front. Vet. Sci.

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“…So far, there is only one non-EEG device tested in dogs, leaving many opportunities to further explore non-EEG seizure detection devices in veterinary medicine. User needs for dog owners appear similar to caregivers for people as for example they both value a high accuracy but would also accept a high false alarm rate ( 2 , 61 ). Although the information on study design and device properties in humans is extensive and could potentially be translated to animals, there are many more challenges faced during the design of such a study in veterinary medicine.…”

Section: Discussionmentioning

confidence: 99%

The Prospects of Non-EEG Seizure Detection Devices in Dogs

2022

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The unpredictable nature of seizures is challenging for caregivers of epileptic dogs, which calls the need for other management strategies such as seizure detection devices. Seizure detection devices are systems that rely on non-electroencephalographic (non-EEG) ictal changes, designed to detect seizures. The aim for its use in dogs would be to provide owners with a more complete history of their dog's seizures and to help install prompt (and potentially life-saving) intervention. Although seizure detection via wearable intracranial EEG recordings is associated with a higher sensitivity in humans, there is robust evidence for reliable detection of generalized tonic-clonic seizures (GTCS) using non-EEG devices. Promising non-EEG changes described in epileptic humans, include heart rate variability (HRV), accelerometry (ACM), electrodermal activity (EDA), and electromyography (EMG). Their sensitivity and false detection rate to detect seizures vary, however direct comparison of studies is nearly impossible, as there are many differences in study design and standards for testing. A way to improve sensitivity and decrease false-positive alarms is to combine the different parameters thereby profiting from the strengths of each one. Given the challenges of using EEG in veterinary clinical practice, non-EEG ictal changes could be a promising alternative to monitor seizures more objectively. This review summarizes various seizure detection devices described in the human literature, discusses their potential use and limitations in veterinary medicine and describes what is currently known in the veterinary literature.

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“…Indeed, seizure counts based on seizure diaries are often inaccurate and underestimated ( 351 , 352 ). Similar to the situation in human epilepsy, the unpredictability of seizures plays a major part in the management of canine epilepsy, and dog owners have a strong desire to know when a seizure occurs ( 353 ). Automated seizure detection by reliable seizure detection devices would be important to guide treatment decisions or monitor outcomes in clinical trials in both human and canine patients.…”

Section: Use Of Dogs As a Translational Model In Epilepsy Research An...mentioning

confidence: 99%

Dogs as a Natural Animal Model of Epilepsy

Löscher

2022

Front. Vet. Sci.

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Epilepsy is a common neurological disease in both humans and domestic dogs, making dogs an ideal translational model of epilepsy. In both species, epilepsy is a complex brain disease characterized by an enduring predisposition to generate spontaneous recurrent epileptic seizures. Furthermore, as in humans, status epilepticus is one of the more common neurological emergencies in dogs with epilepsy. In both species, epilepsy is not a single disease but a group of disorders characterized by a broad array of clinical signs, age of onset, and underlying causes. Brain imaging suggests that the limbic system, including the hippocampus and cingulate gyrus, is often affected in canine epilepsy, which could explain the high incidence of comorbid behavioral problems such as anxiety and cognitive alterations. Resistance to antiseizure medications is a significant problem in both canine and human epilepsy, so dogs can be used to study mechanisms of drug resistance and develop novel therapeutic strategies to benefit both species. Importantly, dogs are large enough to accommodate intracranial EEG and responsive neurostimulation devices designed for humans. Studies in epileptic dogs with such devices have reported ictal and interictal events that are remarkably similar to those occurring in human epilepsy. Continuous (24/7) EEG recordings in a select group of epileptic dogs for >1 year have provided a rich dataset of unprecedented length for studying seizure periodicities and developing new methods for seizure forecasting. The data presented in this review substantiate that canine epilepsy is an excellent translational model for several facets of epilepsy research. Furthermore, several techniques of inducing seizures in laboratory dogs are discussed as related to therapeutic advances. Importantly, the development of vagus nerve stimulation as a novel therapy for drug-resistant epilepsy in people was based on a series of studies in dogs with induced seizures. Dogs with naturally occurring or induced seizures provide excellent large-animal models to bridge the translational gap between rodents and humans in the development of novel therapies. Furthermore, because the dog is not only a preclinical species for human medicine but also a potential patient and pet, research on this species serves both veterinary and human medicine.

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Owner's Perception of Seizure Detection Devices in Idiopathic Epileptic Dogs

Cited by 6 publications

References 32 publications

Detection of Generalized Tonic–Clonic Seizures in Dogs With a Seizure Detection System Established Using Acceleration Data and the Mahalanobis Distance: A Preliminary Study

Detection of Generalized Tonic–Clonic Seizures in Dogs With a Seizure Detection System Established Using Acceleration Data and the Mahalanobis Distance: A Preliminary Study

The Prospects of Non-EEG Seizure Detection Devices in Dogs

Dogs as a Natural Animal Model of Epilepsy

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