Ovulatory status and follicular response predict success of clomiphene citrate-intrauterine insemination

Park, Susanna J.; Álvarez, Jesús de la Ascensión Salas; Weiss, Gerson; Hagen, Stanley Von; Smith, Dayna; McGovern, Peter G.

doi:10.1016/j.fertnstert.2006.11.037

Cited by 15 publications

(14 citation statements)

References 24 publications

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“…When six or more follicles are present, the incidence of HOMP is 14% for women aged <35 and 5% for ages 35-42 in CC-IUI cycles (40). In other modern series of 500 or more CC-IUI cycles, twin implantations occurred in 9%-14%, HOMP occurred in 1.5%-1.6%, and HOMB occurred in 0.4-0.8% of pregnancies (48,66,67).…”

Section: Techniques To Reduce Homp Overviewmentioning

confidence: 95%

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Strategies to reduce multiple pregnancies due to ovulation stimulation

Dickey

2009

Fertility and Sterility

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Section: Techniques To Reduce Homp Overviewmentioning

confidence: 95%

“…In CC-IUI cycles where male factor may or may not be present, pregnancy rates average 6%-11% through 4-6 cycles, with a marked fall-off after the sixth cycle (45,48,66,67).…”

Section: Techniques To Reduce Homp Overviewmentioning

confidence: 99%

Strategies to reduce multiple pregnancies due to ovulation stimulation

Dickey

2009

Fertility and Sterility

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“…[25][26][27] In this single case, after three failed clomid cycles, this patient with DOR had reduced FSH improved AFC after adjuvant TCM treatment. However, she was still unable to conceive when she underwent three more cycles with clomid.…”

Section: Discussionmentioning

confidence: 62%

“…Favorable reproductive outcomes in patients with DOR-even with pharmaceuticals and reproductive technology-are substantially lower than other infertility diagnostic groups. 2,[25][26][27] TCM fertility specialists frequently treat patients who have undergone-or will soon undergo-many rounds of clomid. It is important to recommend a second opinion when a patient has already completed three cycles using this medication and when research shows clearly that many clomid interventions are not successful.…”

Section: Discussionmentioning

confidence: 99%

“…It is important to recommend a second opinion when a patient has already completed three cycles using this medication and when research shows clearly that many clomid interventions are not successful. [25][26][27] In addition, there is a challenge for acceptance of adjuvant Chinese herbal therapy with clomid, as Chinese herbs may improve clomid interventions. 28 It is possible this patient would not have conceived regardless of the three additional clomid cycles after 3 months of TCM treatment.…”

Section: Discussionmentioning

confidence: 99%

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Diminished Ovarian Reserve, Clomid, and Traditional Chinese Medicine: A Case Study

Rubin

Marx

2012

Medical Acupuncture

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Background: Infertility caused by diminished ovarian reserve (DOR) can result from an endocrinological imbalance. A rise in follicle stimulating hormone (FSH) and decrease in antral follicle count (AFC) for women age £ 35 can lower pregnancy rates to <5%, and increase miscarriage rates to >75%. Chinese medicine may improve FSH and AFC levels in patients with DOR. It is common for women to seek adjunctive Traditional Chinese Medicine (TCM) treatment with biomedical clomid treatment. Objective: This article reports the case of a female with DOR who had completed three multiple, serial clomid cycles from September to December 2005, and for whom clomid failed. Design, Setting, and Patient: This is a case study of a 34-year-old patient with a 5-year history of infertility caused by DOR. She was treated in a private practice in Bellevue, WA. Intervention: TCM treatment-including acupuncture and herbal therapy-lasted from from January 2007 to April 2007. Main Outcome Measures: The main outcomes sought were improvements in this patient's reproductive hormone panel, including tests for FSH, estradiol, and AFC levels; in addition a pregnancy outcome was desired. Results: After 4 months of TCM treatment, the patient returned to biomedical care. Pregnancy was not achieved during three more clomid cycles, although she had improvements her levels of FSH (from 14.5 mIU/ mL to 8.7 mIU/mL) and AFC (from 10-12 to 16-18 total). After 3 more cycles with clomid, her FSH level increased to 16.8 mIU/mL and her AFC level was <10. Conclusions: After three failed clomid cycles, a patient with DOR had improved FSH and AFC levels when she received TCM treatment. However, this patient was still unable to conceive although three more clomid cycles were attempted. More research is needed to discern demographically which patients benefit best from multiple, serial clomid interventions. In addition, it is important to investigate more-integrative treatments for patients with DOR, including assisted reproductive techniques, acupuncture, and Chinese herbs.

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