Ovulation stigma and concentration of progesterone and estradiol in peritoneal fluid: relation with fertility and endometriosis

Dhont, Marc; Serreyn, Rudolphe; Duvivier, Patricia; Vanluchene, E.; Boever, J. De; Vandekerckhove, D

doi:10.1016/s0015-0282(16)47900-8

Cited by 43 publications

(11 citation statements)

References 9 publications

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“…The total progesterone also was higher in the peritoneal fluid, and much higher in the follicular fluid, than in the serum. Similar results have been reported before: higher total progesterone in the peritoneal fluid than in the serum (Dhont et al, 1984;Melega et al, 1984;Koninckx et al, 1980), and extremely high total progesterone in the follicular fluid (diZerega et al, 1984;Channing et al, 1985). The higher percent free progesterone and free progesterone in the peritoneal and follicular fluid than in the serum suggests that the peritoneal and follicular fluid progesterone has some action on tuba.…”

Section: Unreliablesupporting

confidence: 83%

Changes in Free Progesterone in the Serum, Peritoneal Fluid and Follicular Fluid through the Menstrual Cycle and Pregnancy

1987

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Section: Unreliablesupporting

confidence: 83%

Changes in Free Progesterone in the Serum, Peritoneal Fluid and Follicular Fluid through the Menstrual Cycle and Pregnancy

1987

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“…The association between the LUF syndrome and endometriosis was described in women [27,28,[43][44][45] and primates [46]. Although this association was challenged in the second half of the eighties, this was recently shown to be due to the changing definition of minimal endometriosis after the description of nonpigmented endometriosis [47], whereas the association between typical endometriosis and LUF syndrome remains valid [48,49].…”

Section: Physiopathology Of Endometriosismentioning

confidence: 99%

“…Although this association was challenged in the second half of the eighties, this was recently shown to be due to the changing definition of minimal endometriosis after the description of nonpigmented endometriosis [47], whereas the association between typical endometriosis and LUF syndrome remains valid [48,49]. In healthy women, the steroid hormone concentrations in peritoneal fluid are much higher after ovulation, but this is not observed in women with LUF syndrome [27,28,50]. Since high doses of progesterone were used as a medical treatment of endometriosis, the hypothesis was put forward that an ovulatory cycle is detrimental for endometriosis development, while LUF may facilitate the development of endometriosis.…”

Section: Physiopathology Of Endometriosismentioning

confidence: 99%

“…Indeed, the total concentration is comparable to the plasma concentration, but the sex hormone binding globulin concentration is only 67% of the plasma concentration. The concentration differences with plasma increase progressively, and when the content of the follicle is released into the peritoneal fluid after ovulation, the 17ß-estradiol concentrations increase abruptly, reaching concentrations 100 times higher than in plasma [24,[25][26][27][28]. During the luteal phase the 17ß-estradiol concentrations decrease progressively, but remain always higher than the plasma concentrations.…”

Section: Introductionmentioning

confidence: 97%

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Pathogenesis of Endometriosis: The Role of Peritoneal Fluid

Koninckx

Kennedy

1999

Gynecol Obstet Invest

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Peritoneal fluid is a specific microenvironment. It originates mainly as an ovarian exudation product due to increased vascular permeability, and contains large amounts of macrophages and their secretion products, which include growth factors, cytokines and angiogenic factors. Similarly, within the ovary, there is also a specific microenvironment, best characterised by the follicular milieu with steroid hormone concentrations that are 1,000 times higher than in plasma. Since endometrial cells in peritoneal fluid and superficially implanted cells will be influenced by peritoneal fluid concentrations, any differences found between minimal endometriosis and eutopic endometrium could be the consequence of their different local environments, rather than inherent cellular differences. Superficial endometrial implants may be regulated by factors in peritoneal fluid, while deep endometriosis and cystic ovarian endometriosis may be under the influence of factors in blood and within the ovary, in which case minimal endometriosis may be physiologic only, while deep endometriosis and cystic ovarian endometriosis, both associated with pelvic pain and infertility, may be a pathological state. In conclusion, the local endocrine environment, that is, in blood, peritoneal fluid, and within the ovary, should be taken into account to explain the differences between superficial, deep and cystic ovarian endometriosis, together with inherent differences in the endometrial cells of women with and without endometriosis.

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“…1982;Dmowski et al 1980). Other investigators have also failed to find an increased frequency of LUF in endometriosis generally (Dhont et al 1984) and in mild disease in particular (Donnez & Thomas 1982).…”

mentioning

confidence: 95%

Follicle growth patterns and endocrinological abnormalities in infertile women with minor degrees of endometriosis

Thomas

Lenton

Cooke

1986

BJOG

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Summary. Eighteen patients whose only demonstrable cause of infertility was a minor degree of endometriosis and whose partners were normal, were investigated prospectively for one menstrual cycle using ultrasonography and endocrine profiles. Twelve cycles appeared to be normal. A luteinized unruptured follicle (LUF) occurred in two cycles and one patient had a follicular cyst. In a further two patients there was inadequate or abnormal folliculogenesis whilst in the last patient the follicle ruptured prematurely. This study describes the variety of endocrinological abnormalities found in women with mild endometriosis, and concludes that, in this series at least, there is a low frequency of LUF.

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Ovulation stigma and concentration of progesterone and estradiol in peritoneal fluid: relation with fertility and endometriosis

Cited by 43 publications

References 9 publications

Changes in Free Progesterone in the Serum, Peritoneal Fluid and Follicular Fluid through the Menstrual Cycle and Pregnancy

Changes in Free Progesterone in the Serum, Peritoneal Fluid and Follicular Fluid through the Menstrual Cycle and Pregnancy

Pathogenesis of Endometriosis: The Role of Peritoneal Fluid

Follicle growth patterns and endocrinological abnormalities in infertile women with minor degrees of endometriosis

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