Ovulation rate and egg recovery in cattle treated repeatedly with pregnant mare serum gonadotrophin and prostaglandin

Christie, W. B.; Newcomb, R.; Rowson, L. E. A.

doi:10.1136/vr.104.13.281

Cited by 21 publications

(4 citation statements)

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“…In cattle, eCG is largely used in zootechnical programs in order to stimulate follicular growth and ovulation: treatment of anoestrus [19], synchronisation or induction of oestrus in combination with progestagens (400 to 600 IU once a year) [7,12], induction of superovulation (1 000 to 2 000 IU) [2,16,35] and more recently, stimulation of follicular growth in ovum pick-up programs (OPU) [15,21]. The higher doses and the higher frequency administration of eCG in OPU programs may have an influence on eCG antibody production in the cow and may induce a reduction in the efficiency of such treatments.…”

Section: Radiolabeling With 125 Iodinementioning

confidence: 99%

Increase of plasma eCG binding rate after administration of repeated high dose of eCG to cows

Drion

Roover²,

Houtain³

et al. 2001

Reprod. Nutr. Dev.

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-Equine chorionic gonadotrophin (eCG) is still used to promote follicular growth in cattle and, more recently with an increased frequency of administration, in ovum pick-up protocols. The aim of this experiment was to verify the possible effect of high frequency of administration on the immune response to eCG. The profiles of eCG binding rate, in the blood of two groups (A, B) of 4 primiparous cross breed beef cows (3-3.5 years old) submitted weekly for 5 to 10 weeks to repeated high doses (1 000-2 000 IU) of equine chorionic gonadotrophin, are presented in this paper. A sensitive radiometric method was used to detect antibodies in plasma. The profiles clearly indicated a marked increase of eCG binding rate after 3 to 5 injections of the exogenous hormone to the females. The statistical analysis of the results established that treatments induced a significant increase (P < 0.01) in binding rates after 6 and 3 injections in group A and B respectively. These binding rates remained elevated for at least 1 week following the last injection and decreased afterwards. The values of plasma binding rates following repeated eCG administration differed significantly between groups (0.90 ± 1.04 and 1.04 ± 0.11 for groups A and B before treatment versus 11.77 ± 0.92, 6.70 ± 0.85 for groups A and B after treatment, P < 0.01) and from one cow to another (P < 0.01) with some cows presenting no significant immune response while others were more reactive against the hormone (at least 3 injections).cow / eCG / antibody Reprod. Nutr. Dev. 41 (2001) 207-215 207

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Section: Radiolabeling With 125 Iodinementioning

confidence: 99%

Increase of plasma eCG binding rate after administration of repeated high dose of eCG to cows

Drion

Roover²,

Houtain³

et al. 2001

Reprod. Nutr. Dev.

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“…Although some studies showed no significant reduction of ovulation in repeated treatments [34][35][36], other studies indicated r e d u c e d r e s p o n s e s t o s e c o n d a n d l a t e r superovulatory treatments of cows in consecutive years [9,37,38] and within the same year [8,[39][40][41]. About 15 to 20 eggs in total were usually collected from the first three flushings.…”

Section: Discussionmentioning

confidence: 99%

Effect of Repeated Treatments with Thyroxine (T4) and Gonadotropins on Ovulation in Hypothyroid rdw Rats.

Jiang

Izutsu

Kimura

et al. 2002

Journal of Reproduction and Development

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Abstract. We previously reported that thyroxine (T4) treatment significantly improved follicular development and increased the number of eggs ovulated in immature hypothyroid infertile rdw rats in the presence of gonadotrophins. The present study was conducted to determine whether (1) infertile rdw rats would respond to repeated stimulation with gonadotrophins, and whether (2) T4 treatment would increase the total number of ovulated eggs in an individual rat induced to ovulate up to three consecutive times at intervals of about 30 days. eCG was repeatedly given from the immature stage on postnatal day 28 and then at day of metestrus in the mature stage at intervals of about 30 days, followed by hCG 54 h later in rdw and normal rats, both of which were also given T4 (T4-rdw and T4-Normal), and in normal rats without T4 treatment (Normal). The results indicate that there were no significant differences in the weights of ovaries at any age tested among T4-rdw, T4-Normal and Normal. The number of eggs ovulated in the first treatment was significantly higher than in subsequent treatments in the same group (P<0.05). No significant differences were observed in the number of eggs ovulated in each corresponding treatment among the three groups, although more eggs (85.0 ± 4.6) were collected after the first treatment in T4-rdw than in the other groups, while fewer eggs (4.0 ± 2.7) were collected in the third treatment in T4-Normal than in the other groups. There were no significant differences in the percentages of degenerative or fertilized eggs in the same treatment among groups or among subsequent treatments in the same groups. However, the total number of eggs collected in the first three treatments in T4-rdw was significantly more than in Normal (P<0.05). T4 treatment also increased the total number of eggs ovulated in first three treatments in normal rats compared to those in Normal although no significant difference was observed between the two groups. In conclusion, the results of the present study indicate that infertile rdw rats responded well to repeated stimulation with gonadotrophins, and that T4 treatment increased the total number of ovulated eggs in an individual rat treated three times with gonadotrophins.

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“…Studies on cattle (Willet et al, 1953;Christie et al, 1979;Alwan et al, 1988), and goats (Maurer et al, 1968;Gherardi and Martin, 1978;Armstrong et al, 1983;Remy et al, 1991;Baril et al, 1992b;Beckers et al, 1995) (Pignon et al, 1960;Jainudeen et al, 1966;Maurer et al, 1968;Alwan et al, 1988;Bavister et al, 1986;Remy et al, 1991;Baril et al, 1992b). Moreover, Beckers et al (1995) showed that goats treated with eCG, transmitted anti-eCG antibodies in their colostrum.…”

mentioning

confidence: 99%

“…Several studies in cattle sheep and goats have shown that for large scale superovulation, porcine pituitary extract (Willet et al, 1953;Remy et al, 1991;Staigmiller et al, 1992) or a crude extract of PMSG (Willet et al, 1953;Gherardi and Martin, 1978;Christie et al, 1979;Armstrong et al, 1983;Bavister et al, 1986;Baril et al, 1992a, b;Beckers et al, 1995) can be used as a source of FSH activity. However, for oestrus synchronisation even though pFSH can be used, PMSG is preferable because it is administred in a single dose.…”

mentioning

confidence: 99%

Anti-PMSG antibody levels in sheep subjected annually to oestrus synchronisation

et al. 1997

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Ovulation rate and egg recovery in cattle treated repeatedly with pregnant mare serum gonadotrophin and prostaglandin

Cited by 21 publications

References 0 publications

Increase of plasma eCG binding rate after administration of repeated high dose of eCG to cows

Increase of plasma eCG binding rate after administration of repeated high dose of eCG to cows

Effect of Repeated Treatments with Thyroxine (T4) and Gonadotropins on Ovulation in Hypothyroid rdw Rats.

Anti-PMSG antibody levels in sheep subjected annually to oestrus synchronisation

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