Ovulation prediction: Changes in the concentrations of urinary estrone-3-glucuronide, estradiol-17β-glucuronide and estriol-16α-glucuronide during conceptional cycles

Branch, Christine M.; Collins, P. O.; Collins, William P.

doi:10.1016/0022-4731(82)90189-3

Cited by 32 publications

(12 citation statements)

References 11 publications

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“…The value for E2-17-G in the pres¬ ent study was almost the same as that reported by Wright et al (1979) but much lower than that reported by Stanczyk et al (1980). Branch et al (1982) reported changes in the concentrations of E2-17-G in the early morning urine samples during conceptional cycles. The peak of urinary E2-17-G appeared 0.8 day before the peak of urinary LH.…”

Section: Discussionsupporting

confidence: 76%

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Conjugated oestrogen during the menstrual cycle measured by a direct radioimmunoassay with an antiserum prepared against oestradiol-17-glucosiduronate-[C-6]-BSA conjugate

Honjo

OTSUBO

Yasuda

et al. 1984

Acta Endocrinologica

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Early morning and 24 h urine samples and serum were collected daily throughout the menstrual cycle in women. Urinary oestradiol-17-glucosiduronate (E2-17-G) was measured with a direct radioimmunoassay whose antiserum had been prepared against E2-17-G\x=req-\ [C-6]-bovine serum albumin conjugate and was very specific. On the average, E2-17-G in early morning and 24 h urine samples showed a prominent peak one day before the peak of urinary LH. The time relationship between these urinary E2-17-G and serum E2 levels and peaks was also investigated.

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Section: Discussionsupporting

confidence: 76%

“…Recently, a midcycle peak of urinary oestradiol 17-G(E2-17-G) during the men¬ strual cycle in women was reported (Wright et al 1979;Stanczyk et al 1980;Branch et al 1982). However, little is known about these endogenous conjugated oestrogens.…”

mentioning

confidence: 96%

Conjugated oestrogen during the menstrual cycle measured by a direct radioimmunoassay with an antiserum prepared against oestradiol-17-glucosiduronate-[C-6]-BSA conjugate

Honjo

OTSUBO

Yasuda

et al. 1984

Acta Endocrinologica

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“…8 days later. In non-pregnant 1000 -8 -6-4-2 (Branch, Collins & Collins, 1982) and non-human primates (Lasley, Hodges & Czekala, 1980). In the mare, plasma conjugated oestrogens are present in 100-fold higher concentrations than the unconjugated forms (Palmer & Terqui, 1977) and oestrone sulphate may well be a useful index for monitoring follicular development.…”

Section: Animalsmentioning

confidence: 99%

Changes in oestrone sulphate concentrations in peripheral plasma of Pony mares associated with follicular growth, ovulation and early pregnancy

Makawiti¹,

Allen²,

Kilpatrick³

1983

Reproduction

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Summary. A simple and rapid ( < 2 h) immunoassay method has been developed based upon a novel separation technique called LIDIA (Ligand Differentiation Immunoassay), enabling direct estimation of the concentration of oestrone sulphate in ethanolic extracts of blood plasma. An antiserum raised against oestrone-3-glucuronyl\p=n-\BSA was used which showed a higher cross-reaction with the sulphate than the glucuronide metabolite. The assay had a sensitivity of 5\m=.\2 pg/tube and acceptable inter-( < 18%) and intra-(<8\m=.\5%)assay precision. Analysis of samples of peripheral venous plasma obtained daily from Pony mares showed that the mean concentration of oestrone sulphate started to rise from a baseline value ( < 300 pg/ml) at 6 days and reached a peak ( > 850 pg/ml) at 2 days before follicular rupture as determined by rectal palpation. Progesterone concentrations only started to rise above baseline ( < 0\m=.\5 ng/ml) on the day of ovulation and reached a peak 8 days later. Analysis of samples obtained during the first 30 days of pregnancy showed that there was no increase in oestrone sulphate at the time oestrus would have been expected had the mares not conceived.

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“…1,2 E 2 is the most active estrogenic hormone and increasing levels of E 2 bring about changes in cervical mucus, making it more favorable for survival and transport of Metabolites of E 2 , including estradiol-3-glucuronide, estradiol-17-β-glucuronide, estrone-3-glucuronide (E3G) and estriol-16-α-glucuronide, can also be measured in plasma, cervicovaginal fluid and urine. 8 Studies have demonstrated a correlation between concentrations of E 2 present in plasma and concentrations of E3G present in early-morning urine, 8,9 and it has been established that monitoring E3G levels in urine provides a viable mechanism for identifying the start of the potentially fertile period. 10,11 Assessment of E3G levels in samples of early-morning urine has been shown to be 83 -89% successful in delineating the probable fertile period.…”

Section: Introductionmentioning

confidence: 99%

Trial Protocol and Sample Result of a Study Comparing the ClearPlan Easy™ Fertility Monitor with Serum Hormone and Vaginal Ultrasound Measurements in the Determination of Ovulation

Behre¹

2001

J Int Med Res

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This paper presents a preliminary result from a study designed to evaluate the ability of the ClearPlan Easy™ Fertility Monitor* to predict ovulation, compared with conventional methods of ovulation determination, i.e. serum hormone measurements (estradiol and luteinizing hormone) and vaginal ultrasound scans (follicle size and endometrium thickness). Fifty-five female volunteers will be monitored over 3 consecutive monthly cycles. Preliminary data gathered from one volunteer are included in this presentation. These data indicate that the ClearPlan Easy™ Fertility Monitor predicted ovulation as accurately as serum hormone measurements and vaginal ultrasound scans. The results show that this monitor has potential as a home-based ovulation predictor for couples attempting to conceive.

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Ovulation prediction: Changes in the concentrations of urinary estrone-3-glucuronide, estradiol-17β-glucuronide and estriol-16α-glucuronide during conceptional cycles

Cited by 32 publications

References 11 publications

Conjugated oestrogen during the menstrual cycle measured by a direct radioimmunoassay with an antiserum prepared against oestradiol-17-glucosiduronate-[C-6]-BSA conjugate

Conjugated oestrogen during the menstrual cycle measured by a direct radioimmunoassay with an antiserum prepared against oestradiol-17-glucosiduronate-[C-6]-BSA conjugate

Changes in oestrone sulphate concentrations in peripheral plasma of Pony mares associated with follicular growth, ovulation and early pregnancy

Trial Protocol and Sample Result of a Study Comparing the ClearPlan Easy™ Fertility Monitor with Serum Hormone and Vaginal Ultrasound Measurements in the Determination of Ovulation

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