Ovulation induction with urinary FSH or recombinant FSH in polycystic ovary syndrome patients: a prospective randomized analysis of cost-effectiveness

Promoter Methylation of <b><i>CYP19A1</i></b> Gene in Chinese Polycystic Ovary Syndrome Patients

“…Polycystic ovary syndrome (PCOS) is a common heterogeneous disorder in women of child-bearing age, and the most common cause of female infertilitydue to anovulation [1,2]. Whilst the pathogenesis of PCOS remains largely unknown, accumulating data suggest that PCOS is a complex disease which involves both genetic and environmental factors [3,4,5].…”

Recombinant FSH versus highly purified FSH in intrauterine insemination: systematic review and metaanalysis

“…In the other three reports (9-11) the ratio of the HP-FSH:rec-FSH was 1.5. In one of these studies, 150 IU HP-FSH was compared with 100 of rec-FSH (9) and in the remaining two 75 IU HP-FSH were compared with 50 IU rec-FSH (10,11). In addition, there were some other differences in cycle management (Table 1) and regarding inclusion criteria.…”

“…When the results of these three studies were pooled, the PCPR was 16.36% in the rec-FSH group, significantly higher than the 12.31% of the HP-FSH group (RR, 1.394; 95% CI, 1.004-1.936). When the metaanalysis was performed on just the studies in which the HP-FSH:rec-FSH ratio was 1.5, the PCPR was favored by HP-FSH in one trial (10) and in two by rec-FSH (9,11), all of them without statistical significance. When these results were pooled, the PCPRs in the rec-FSH and in HP-FSH groups were highly similar (14.51% vs. 14.93%; RR, 0.970; 95% CI, 0.687-1.369; Supplemental Text 3 and Supplemental Fig.…”

“…In the third study (8), ovarian stimulation was performed with rec-FSH (Gonal f) or HP-FSH (Metrodin-HP): 75 UI FSH if body mass index (BMI) was <25 kg/m 2 and 150 UI if BMI was R25 kg/m 2 (10). Another arm of the treatment consisted of hMG stimulation (not considered in the present metaanalysis).…”

What is the Clinical Relevance of Follicle-Stimulating Hormone Isoforms in Fertility Treatment?

“…Whether administered as u-hFSH alone or in combination with LH activity (as in hMG), higher doses are needed and may result in fewer oocytes than r-hFSH. [44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60]65 This again highlights that the more basic isoform profile of r-hFSH may be more effective in recruiting follicles than u-hFSH or hMG (which contain less potent, more acidic FSH isoforms) and thereby results in the retrieval of higher numbers of oocytes.…”