Ovulation induction and pregnancies in 100 consecutive women with hypergonadotropic amenorrhea

Check, Jerome H.; Nowroozi, Kosrow; Chase, Jeffrey S.; Nazari, Ahmad; Shapse, Deborah; Vaze, Milind

doi:10.1016/s0015-0282(16)53514-6

Cited by 92 publications

(15 citation statements)

References 10 publications

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“…Previous studies have shown a favorelevated basal FSH do poorly with such subsequent able effect of the "flare" protocol in low responders stimulation (26). Our data expand on this information (11,22) and pretreatment cycle with estrogen (23) and and confirm that using OCP or gestogen, which will the use of the oral contraceptive pill before commenclower the basal FSH, apparently does not improve the ing COH (11,18) presumably by eliminating the exisclinical outcome in low responders. Our findings also tence of the corpus luteum, suppressing endogenous support other earlier reports that concluded that FSH to normal, and restoring the sensitivity in the increasing the hMG dose does not improve the prognoovarian follicle to exogenous FSH.…”

Section: Methodssupporting

confidence: 71%

Untitled

Al-Mizyen

Sabatini

Lower

et al. 2000

Journal of Assisted Reproduction and Genetics

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Section: Methodssupporting

confidence: 71%

Untitled

Al-Mizyen

Sabatini

Lower

et al. 2000

Journal of Assisted Reproduction and Genetics

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“…Previous studies showed successful ovulation induction rates in patients with normal and abnormal karyotypes, ranging between 0%-46%, with clinical parameters varying among the reports. 11,13,[19][20][21][22] In our hospital, the success of ovulation induction under ovarian stimulation in patients with normal karyotype was 48% per patient during six years of observation. 23 Although the method for data collection was not identical, the success of ovulation induction was quite similar between POI patients with normal and abnormal and karyotypes.…”

Section: Discussionmentioning

confidence: 99%

“…10 Previous studies on reproductive outcomes using different protocols focused on POI patients with normal karyotypes, 11,12 or did not assess for chromosomal abnormalities. [13][14][15][16] It was recently suggested that women with POI and an abnormal karyotype might have a reduced chance of conceiving using their own eggs, compared to women with POI from non-genetic causes. 17 However, the literature concerning the reproductive outcome of POI with an abnormal karyotype is still scarce.…”

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confidence: 99%

Impact of abnormal karyotype on reproductive outcome in premature ovarian insufficiency

Grin

Ishizuka

Onimaru

et al. 2022

Reprod Medicine & Biology

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Purpose This study evaluated the reproductive potential of premature ovarian insufficiency (POI) patients with abnormal karyotypes undergoing infertility treatments. Methods A retrospective analysis of infertility treatments in POI patients with an abnormal karyotype treatment. Clinical and laboratory data were analyzed. Results The study group was forty‐nine POI patients. Follicular growth was achieved in 29% (89/307) controlled ovarian stimulation (COS) cycles in 57% (28/49) of patients. Oocyte retrieval was attempted in 47% (23/49) of patients with a proportion of successful oocyte retrieval per oocyte pick‐up (OPU) of 59.4% (41/69). The average number of retrieved oocytes was 2.4 ± 2.7 per patient and fertilization rate was 70.7% (29/41). Embryo transfer (ET) performed in eight patients with a total of nine ET attempts, resulting in 33.3% (3/9) of live birth rate per ET. Three patients delivered a healthy baby (6.1% (3/49) of live birth rate per patient). Mosaic Turner syndrome patients had a longer duration of amenorrhea and lower chances of successful follicular growth with OPU in 35.7% (5/14) of patients, whereas 47XXX had shorter duration of amenorrhea and COS with follicle growth with OPU in 83.3% (5/6). Conclusion COS might provide an opportunity for POI women with abnormal karyotypes to conceive a biological offspring.

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“…These results may indicate that autoimmunity plays a role in the etiology of POI. Check et al (12), in their study, suggested that gonadotropin suppression with estrogen replacement and GnRH agonides with longer OS periods with recombinant FSH or human menopausal gonadotropin (hMG) may have better ovulation and pregnancy rates if patients have longer periods of amenorrhea. In a comparative study by Ishuzuka et al (13), they compared pregnancy rates in POI patients who underwent hormone replacement therapy (HRT) with or without ovarian stimulation between 2014 and 2020 in a clinic.…”

Section: Fertility Treatmentsmentioning

confidence: 99%

Erken Yumurtalık Yetersizliğinde Kadın İnfertilitesinin Optimizasyonu

AYTAÇ¹

2022

Düzce Tıp Fakültesi Dergisi

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Erken yumurtalık yetmezliği, az bilinen etiyolojisi ile neden olduğu yumurtalık hormonlarının azalmasıyla saptanan, kadınlarda birçok sistemi etkileyen patolojilere yol açar. Etiyolojisini belirlemeye yönelik çalışmalarda pek çok hastanın açıklanamayan grupta olduğu görülmektedir. Diğer yandan genetik yatkınlık ve otoimmün nedenli erken yumurtalık yetersizliği (premature ovarian insufficiency, POI) bilinen en sık etiyolojik nedenlerdir. Temelde östrojen eksikliği ile ilgili semptomların önlenmesi amacı ile erken tanı ve tedavi önemlidir. Hormon replasman tedavisinin bir an önce başlanması, kadınlarda menopozal semptomların önlenmesini ve uzun dönemli komplikasyonların azalmasını sağlayacaktır. Bu hastalarda diğer önemli sorun ise over yetmezliği ile ortaya çıkan infertilitedir. Aslında adet düzensizliği ortaya çıkmadan önce azalmaya başlayan fertilite, ilerleyen dönemde folikül sayısının daha hızlı azalması ile ciddi bir infertilite sorunu haline gelmektedir. Burada özellikle risk altındaki hastaların tespiti ile uygun zamanda fertilite koruyucu tedaviler (oosit, embryo veya over dokusunun dondurulması gibi) ve yardımla üreme teknikleri önerilebilir. Bununla birlikte, infertilite yakınması olan POI tanısı alan hastalarda; kök hücre tedavisi, trombositten zengin plazma (platelet-rich plasma, PRP) ve over dokusuna in vitro aktivasyon gibi uygulamalar yeni ve deneysel aşamada olsa da gelecekte umut verici olabilir. Sunulan bu derlemede erken yumurtalık yetmezliğinin güncel patofizyolojisi ve tedavi seçenekleri tartışılmıştır.

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Ovulation induction and pregnancies in 100 consecutive women with hypergonadotropic amenorrhea

Cited by 92 publications

References 10 publications

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Impact of abnormal karyotype on reproductive outcome in premature ovarian insufficiency

Erken Yumurtalık Yetersizliğinde Kadın İnfertilitesinin Optimizasyonu

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