Ovulation‐inducing factor (<scp>OIF</scp>/<scp>NGF</scp>) in seminal plasma: a review and update

Adams, G. B.; Ratto, M.H.; Silva, ME; Carrasco, Rodrigo A.

doi:10.1111/rda.12795

Cited by 62 publications

(43 citation statements)

References 93 publications

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“…Furthermore, SP of SACs is also biochemically unique. An ovulation‐inducing protein factor (NGF‐ß) has been described (Adams, Ratto, Silva, & Carrasco, ), that not only induces ovulation by stimulating pituitary LH secretion but also adheres to the sperm membrane (Sari et al, ). On the other hand, a llama seminal lectin (SL15) that is likely adsorbed to spermatozoa via SP during ejaculation and is probably involved in sperm reservoir formation (Zampini, Sequeria, Argañaraz, & Apichela, ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the cryoprotective effect of seminal plasma on llama ( Lama glama) spermatozoa

et al. 2019

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In South American camelids, sperm survival is low after thawing and poor results are obtained when artificial insemination is performed with cryopreserved semen. The aim of this study was to evaluate the effect of different percentages (10% and 50%) of seminal plasma added prior to the process of cryopreservation and also to evaluate the absence of seminal plasma on llama sperm survival after freezing and thawing. A total of 15 ejaculates from five adult llama males (n = 5; r = 3) were evaluated. A significant decrease in sperm motility, viability, membrane function and intact acrosomes was observed in thawed samples (0%, 10% and 50%) when compared to raw semen. Neither morphology nor chromatin condensation was altered in all thawed samples (p > 0.05), but a significant increase (p < 0.05) in the percentage of spermatozoa with fragmented DNA was observed after thawing all samples compared to raw semen. Higher percentages of total and progressive sperm motility were observed when 0% and 10% of seminal plasma were used compared to 50%. However, no statistical differences were established for sperm viability, membrane function, morphology, acrosome status and DNA quality between thawed treatments. To conclude, neither of the percentages of seminal plasma used showed superiority nor cryoprotective effect on llama sperm survival.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the cryoprotective effect of seminal plasma on llama ( Lama glama) spermatozoa

et al. 2019

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“…In llama also, Adams et al (36) reported that β-NGF and TrkA are present in the hypothalamus. Other studies have provided indirect evidences for the involvement of hypothalamus in the β-NGF-induced LH release.…”

Section: Identification Of the β-Ngf Central Target(s): The Kp Neuronmentioning

confidence: 99%

Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis

et al. 2017

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Female mammals are classified into spontaneous and induced ovulators based on the mechanism eliciting ovulation. Ovulation in spontaneous species (e.g., human, sheep, cattle, horse, pigs, and most rodents) occurs at regular intervals and depends upon the circulating estradiol. However, in induced ovulators (e.g., rabbits, ferrets, cats, and camelids), ovulation is associated with coitus. In the later, various factors have been proposed to trigger ovulation, including auditory, visual, olfactory, and mechanic stimuli. However, other studies have identified a biochemical component in the semen of induced ovulators responsible for the induction of ovulation and named accordingly ovulation-inducing factor (OIF). In camelids, intramuscular or intrauterine administration of seminal plasma (SP) was shown to induce the preovulatory luteinizing hormone (LH) surge followed by ovulation and subsequent formation of corpus luteum. Recently, this OIF has been identified from SP as a neurotrophin, the β subunit of nerve growth factor (β-NGF). β-NGF is well known as promoting neuron survival and growth, but in this case, it appears to induce ovulation through an endocrine mode of action. Indeed, β-NGF may be absorbed through the endometrium to be conveyed, via the blood stream, to the central structures regulating the LH preovulatory surge. In this review, we provide a summary of the most relevant results obtained in the field, and we propose a working hypothesis for the central action of β-NGF based on our recent demonstration of the presence of neurons expressing kisspeptin, a potent stimulator of GnRH/LH, in the camel hypothalamus.

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“…China's Bactrian camels are mainly distributed in Xinjiang, Inner Mongolia, Qinghai and Gansu; however in recent decades, camel populations have sharply declined (China Statistical Yearbook‐2016). One reason for this decline is the low reproductive efficiency of camels; they have a long reproductive cycle that progresses slowly although there is a similarity to GnRH/LH inducing factor of β‐NGF, which induce ovulation in female llamas and alpacas (Adams, Ratto, Silva, & Carrasco, ; Berland et al, ; Ratto et al, ). However, male Bactrian camel oestrous mechanism is unknown.…”

Section: Introductionmentioning

confidence: 99%

Screening for reproductive biomarkers in Bactrian camel via iTRAQ analysis of proteomes

Wang

Zhang

Gan

et al. 2020

Reprod Domestic Animals

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Bactrian camel is an ancient and precious species of livestock; that is, unique resources exist in the desert and have important economic and scientific value. In recent years, the number of Bactrian camels has declined sharply. Due to its long reproductive cycle and seasonal oestrus, the mechanism of oestrus is unknown. To identify candidate biomarkers of reproduction, we performed a comprehensive proteomic analysis of serum from Bactrian camel in oestrus and non‐oestrus, using isobaric tags for relative and absolute quantitation (iTRAQ) coupled with tandem mass spectrometry. We identified 359 proteins, of which 32 were differentially expressed: 11 were up‐regulated and 21 were down‐regulated in samples from camels in oestrus. We validated the differential expression of a subset of these proteins using qPCR and Western blot. Gene ontology annotation identified that the differentially expressed proteins function in cellular processes, metabolic processes and immune system processes. Notably, five of the differentially expressed proteins, PCGF5, histone H1.2, RBP4, FOLR1 and ANTXR2, are involved in reproductive regulatory processes in other animals. KEGG enrichment analysis demonstrated significant enrichment in several cardiac‐related pathways, such as ‘dilated cardiomyopathy’, ‘hypertrophic cardiomyopathy’, ‘cardiac muscle contraction’ and ‘adrenergic signalling in cardiomyopathy’. Our results suggest that candidate biomarker (PCGF5, histone H1.2, RBP4, FOLR1 and ANTXR2) discovery can aid in understanding reproduction in Bactrian camels. We conclude that the profiling of serum proteomes, followed by the measurement of selected proteins using more targeted methods, offers a promising approach for studying mechanisms of oestrus.

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Ovulation‐inducing factor (OIF/NGF) in seminal plasma: a review and update

Cited by 62 publications

References 93 publications

Evaluation of the cryoprotective effect of seminal plasma on llama ( Lama glama) spermatozoa

Evaluation of the cryoprotective effect of seminal plasma on llama ( Lama glama) spermatozoa

Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis

Screening for reproductive biomarkers in Bactrian camel via iTRAQ analysis of proteomes

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