Ovulation and birth after administration of progesterone trigger—two case reports

Villar, Lina; Tralik, Beata; Diamond, Michael P.; Allon, Michael; Maldonado, Israel; Dozortsev, Dmitri

doi:10.1007/s10815-023-02750-x

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…In natural menstrual cycle, the onset of LH surge would be triggered by estradiol (E2) originating from the dominant follicle, exceeding 200–300 pg/mL for a minimum of 50 h. 13 Progesterone rise in circulation would be 12 h before LH surge, which also plays an important role in generating LH surge. 14 , 15 Therefore, several medicines are used as a trigger for inducing an endogenous LH surge (GnRH agonist, 16 progesterone, 17 , 18 and kisspeptin 19 ) or mimicking LH function (human chorionic gonadotropin, hCG 20 , 21 ) and ovulation. After LH surge or hCG, a rapid and robust induction of progesterone receptor (PGR) expression is accompanied by expressions of progesterone biosynthetic enzymes in granulosa cells of preovulatory follicles.…”

Section: Introductionmentioning

confidence: 99%

A delayed ovulation of progestin-primed ovarian stimulation (PPOS) by downregulating the LHCGR/PGR pathway

Xie¹,

Guo²,

Shen³

et al. 2023

iScience

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Section: Introductionmentioning

confidence: 99%

A delayed ovulation of progestin-primed ovarian stimulation (PPOS) by downregulating the LHCGR/PGR pathway

Xie¹,

Guo²,

Shen³

et al. 2023

iScience

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Prediction of ovulation: new insight into an old challenge

Maman,

Adashi,

Baum

et al. 2023

Sci Rep

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Ultrasound monitoring and hormonal blood testing are considered by many as an accurate method to predict ovulation time. However, uniform and validated algorithms for predicting ovulation have yet to be defined. Daily hormonal tests and transvaginal ultrasounds were recorded to develop an algorithm for ovulation prediction. The rupture of the leading ovarian follicle was a marker for ovulation day. The model was validated retrospectively on natural cycles frozen embryo transfer cycles with documented ovulation. Circulating levels of LH or its relative variation failed, by themselves, to reliably predict ovulation. Any decrease in estrogen was 100% associated with ovulation emergence the same day or the next day. Progesterone levels > 2 nmol/L had low specificity to predict ovulation the next day (62.7%), yet its sensitivity was high (91.5%). A model for ovulation prediction, combining the three hormone levels and ultrasound was created with an accuracy of 95% to 100% depending on the combination of the hormone levels. Model validation showed correct ovulation prediction in 97% of these cycles. We present an accurate ovulation prediction algorithm. The algorithm is simple and user-friendly so both reproductive endocrinologists and general practitioners can use it to benefit their patients.

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Ovulation and birth after administration of progesterone trigger—two case reports

Cited by 2 publications

References 14 publications

A delayed ovulation of progestin-primed ovarian stimulation (PPOS) by downregulating the LHCGR/PGR pathway

A delayed ovulation of progestin-primed ovarian stimulation (PPOS) by downregulating the LHCGR/PGR pathway

Prediction of ovulation: new insight into an old challenge

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