Ovotoxicity and PPAR-mediated aromatase downregulation in female Sprague–Dawley rats following combined oral exposure to benzo[a]pyrene and di-(2-ethylhexyl) phthalate

Xu, Chuan; Chen, Jian; Qiu, Zhiqun; Zhao, Qing; Luo, Jiaohua; Yang, Lan; Zeng, Hui; Huang, Yujing; Zhang, Liang; Cao, Jia; Shu, Weiqun

doi:10.1016/j.toxlet.2010.09.015

Cited by 85 publications

(56 citation statements)

References 41 publications

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“…like dichlorodiphenyltrichloroethane (DDT), 1, 1-dichloro-2, 2-bis (4-chlorophenyl) ethylene (DDE), Di-(2-ethylhexyl) phthalate (DEHP), mono-2-ethylhexyl phthalate (MEHP) and nitrobenzene have carcinogenic effect which may facilitate in developing arrhenoblastoma and other tumors in ovary (Xu et al, 2010). As in sex reversal, functional ovary of layer chickens become regressed due to arrhenoblastoma, leading to decrease egg production that may lead to economic loss in layer farming.…”

Section: Pesticidesmentioning

confidence: 99%

Investigation of Sex Reversal in Layer Chickens in Bangladesh

Shaikat¹

2015

Adv. Anim. Vet. Sci.

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Section: Pesticidesmentioning

confidence: 99%

Investigation of Sex Reversal in Layer Chickens in Bangladesh

Shaikat¹

2015

Adv. Anim. Vet. Sci.

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“…Several groups have documented the ability of phthalates to cause female reproductive toxicity and the subject has been reviewed previously . In vivo studies in rats showed that di-(2-ethylhexyl) phthalate (DEHP; 300 and 600 mg/kg) significantly decreased levels of E 2 , and aromatase mRNA and protein (Xu et al 2010). In mice, DEHP (1-100 mg/ml) and its metabolite mono-(2-ethylhexyl) phthalate (MEHP; 0.1-10 mg/ml) inhibit antral follicle growth, reduce in vitro E 2 production, and decrease Cyp19a1 expression.…”

Section: Plasticizers: Bisphenol a And Phthalatesmentioning

confidence: 99%

“…One study using isolated preantral follicles from rats showed that treatment with BAP (R1.5 ng/ml) inhibited follicular growth, and decreased E 2 and anti-Mü llerian hormone output (Neal et al 2010). In rats, BAP (5 and 10 mg/kg) has been shown to decrease levels of E 2 and decrease aromatase mRNA and protein (Xu et al 2010). Furthermore, BAP, phenanthrene, and chrysene inhibited androstenedione and E 2 secretion by ovarian tissues of flounder treated with each chemical individually at 15 mM (Monteiro et al 2000, Rocha Monterio et al 2000 and phenanthrenequinone (100-1000 nM), a metabolite of phenanthrene, reduced LH-stimulated progesterone in rat luteal cells (Nykamp et al 2001).…”

Section: Polycyclic Aromatic Hydrocarbonsmentioning

confidence: 99%

Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling

Craig¹,

Wang²,

Flaws³

2011

Reproduction

224

123

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Endocrine-disrupting chemicals (EDCs) are exogenous agents with the ability to interfere with processes regulated by endogenous hormones. One such process is female reproductive function. The major reproductive organ in the female is the ovary. Disruptions in ovarian processes by EDCs can lead to adverse outcomes such as anovulation, infertility, estrogen deficiency, and premature ovarian failure among others. This review summarizes the effects of EDCs on ovarian function by describing how they interfere with hormone signaling via two mechanisms: altering the availability of ovarian hormones, and altering binding and activity of the hormone at the receptor level. Among the chemicals covered are pesticides (e.g. dichlorodiphenyltrichloroethane and methoxychlor), plasticizers (e.g. bisphenol A and phthalates), dioxins, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons (e.g. benzo[a]pyrene).

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“…26 Recent studies have revealed that Yangtze River water contained organic pollutants, which induce estrogenic activities 27 and ovotoxicity. 28 However, limited information is available regarding the transcriptomic and metabnomic toxicities induced by the contaminated source water.…”

Section: Articlementioning

confidence: 99%

Evaluating the Transcriptomic and Metabolic Profile of Mice Exposed to Source Drinking Water

Zhang

et al. 2011

Environ. Sci. Technol.

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Transcriptomic and metabonomic methods were used to investigate mice's responses to drinking source water (DSW) exposure. After mice were fed with DSW for 90 days, hepatic transcriptome was characterized by microarray and serum metabonome were determined by (1)H nuclear magnetic resonance (NMR) spectroscopy. A total of 243 differentially expressed genes (DEGs) were identified, among which 141 genes were up-regulated and 102 genes were down-regulated. Metabonomics revealed significant changes in concentrations of creatine, pyruvate, glutamine, lysine, choline, acetate, lipids, taurine, and trimethylamine oxide. Four biological pathways were identified by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis where both gene expression and metabolite concentrations were altered in response to DSW exposure. These results highlight the significance of combined use of transcriptomic and metabonomic approaches in evaluating potential health risk induced by DSW contaminated with various hazardous materials.

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Ovotoxicity and PPAR-mediated aromatase downregulation in female Sprague–Dawley rats following combined oral exposure to benzo[a]pyrene and di-(2-ethylhexyl) phthalate

Cited by 85 publications

References 41 publications

Investigation of Sex Reversal in Layer Chickens in Bangladesh

Investigation of Sex Reversal in Layer Chickens in Bangladesh

Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling

Evaluating the Transcriptomic and Metabolic Profile of Mice Exposed to Source Drinking Water

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