2017
DOI: 10.3389/fped.2017.00231
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Ovotesticular Differences of Sex Development: Surgery or Not Surgery? That Is the Question

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Cited by 5 publications
(4 citation statements)
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“…Timing of surgery remains controversial 14 . In our cohort, genitoplasty and gonad surgery were mostly carried out as early as possible after diagnosis, until 2015.…”
Section: Discussionmentioning
confidence: 99%
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“…Timing of surgery remains controversial 14 . In our cohort, genitoplasty and gonad surgery were mostly carried out as early as possible after diagnosis, until 2015.…”
Section: Discussionmentioning
confidence: 99%
“…Very few studies with a specific attention to 46,XX SRY ‐negative T/OTDSD have reported the medical and surgical management of these patients as well as long‐term outcomes 11‐13 . Particularly, timing of surgery is controversial in the management of OTDSD patients 14 . Recent studies also suggest the possibility of development of gender dysphoria in these patients 15 .…”
Section: Introductionmentioning
confidence: 99%
“…Differential diagnosis of 46, XX testicular DSD, which is 46, XX karyotype and phenotypic males with testes, is ovotesticular DSD (Grinspon & Rey, 2016). Early gonadectomy for one option may be considered since gonadal tumors with malignant potential occur in approximately 3% of all cases of ovotesticular DSD containing Y materials, although the recent international trend is to wait for surgery until becoming an adult (Scarpa, 2017), giving importance to an exclusion diagnosis. In comparison to 46, XX testicular DSD, ambiguous genitalia is the common manifestation in 90% of the cases and normal genitalia is in 10% of the cases (Sultan et al, 2002).…”
Section: Discussionmentioning
confidence: 99%
“…Although the clinical presentation is highly variable, the external genitalia are usually ambiguous but can range from normal male to normal female and if a uterus and/or fallopian tubes are present, they are generally hypoplastic. Cryptorchidism, hypospadias, and infertility are frequently associated and confer a relatively low risk of germ cell malignancy relative to other DSDs such as gonadal dysgenesis [Lee et al, 2006;Becker and Akhavan, 2016;Scarpa, 2017].…”
Section: Discussion/conclusionmentioning
confidence: 99%