Ovine squamous cell carcinoma: immunocharacterisation of neoplastic cells and peritumoural cellular infiltrate

Pérez, J.; Méndez, Aniceto Delgado; Lara, F. Chacón-M. de; Martín, Margarita; Mozos, E.

doi:10.1016/s0034-5288(97)90156-9

Cited by 11 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results obtained by Perez et al [ 36 ] with the first antibody are similar to our results obtained with the MNF116 antibody, with immunopositivity in the majority of neoplastic cells. However, the antibody against K8/K18 and K19 did not react with the neoplastic cells in the referred study [ 36 ].…”

Section: Discussionsupporting

confidence: 92%

“…The only imunohistochemical profile of SCC in domestic animals was performed in sheep, using two monoclonal antibodies, one against K5 and K8, and the other to K8/K18 and K19 [ 36 ]. Results obtained by Perez et al [ 36 ] with the first antibody are similar to our results obtained with the MNF116 antibody, with immunopositivity in the majority of neoplastic cells. However, the antibody against K8/K18 and K19 did not react with the neoplastic cells in the referred study [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, there are several immunohistochemical (IHC) studies focusing on pre-neoplastic lesions and epidermic/oral SCC in man [ 29 , 30 , 31 , 32 ] and in small animals [ 33 , 34 , 35 ] but very few in farm animals [ 1 , 36 , 37 ]. Since every effort is needed to improve knowledge on the biology of tumours and search for predictive factors on the prognosis, the aim of this study was to evaluate the histological and IHC features of BOSCC.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical Studies of Cytokeratins and Differentiation Markers in Bovine Ocular Squamous Cell Carcinoma

Vala

Carvalho

Pinto

et al. 2020

Veterinary Sciences

View full text Add to dashboard Cite

Bovine Ocular Squamous Cell Carcinoma is considered the most common bovine tumour, causing significant economic losses, mainly by abattoir condemnations. To obtain a better insight into the genesis and neoplastic transformation, 19 samples collected at slaughter from Holstein Friesian cattle and diagnosed as Ocular Squamous Cell Carcinoma were studied. Tumours were histologically classified into three categories: poorly (26.3%), moderately (26.3%), and well differentiated (47.4%). Expression of keratins (MNF116 and LP34) and of cornified envelope precursors (involucrin and profilaggrin) was studied. Expression of MNF116 was observed in all carcinomas. LP34 immunostaining was seen in all but three carcinomas, one from each degree. Involucrin immunoreaction was observed in all but one poorly differentiated carcinoma. Profilaggrin was present in only two moderately differentiated carcinomas, in all but one well differentiated, and in all but one poorly differentiated. MNF116 is a useful marker to confirm the epithelial origin of the tumour and stain most neoplastic cells in these tumours. The expression of involucrin and LP34 demonstrates that, in all tumours, cells have reached the final program of differentiation, regardless of the grade. The expression of profilaggrin could indicate molecular changes during malignant transformation but their expression does not seem to be of diagnostic value.

show abstract

Section: Discussionsupporting

confidence: 92%