Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care

Abstract

Significance: Broad-spectrum metalloproteinase (MMP) reduction along with inherent aspects of an extracellular matrix (ECM) dressing can bring about improved wound healing outcomes and shorter treatment duration. Initial reports of clinical effectiveness of a new ovine-based collagen extracellular matrix (CECM) dressing demonstrate benefits in chronic wound healing. Recent Advances: CECM dressings are processed differently than oxidized regenerated cellulose/collagen dressings. CECM dressings consist primarily of collagens I and III arranged as native fibers that retain the three-dimensional architecture present in tissue ECM. As such, ovine-based ECM dressings represent a new generation of collagen dressings capable of impacting a broad spectrum of MMP excess known to be present in chronic wounds. Critical Issues: While MMPs are essential in normal healing, elevated presence of MMPs has been linked to wound failure. Collagen has been shown to reduce levels of MMPs, acting as a sacrificial substrate for excessive proteases in a chronic wound. Preserving collagen dressings in a more native state enhances bioactivity in terms of the ability to affect the chronic wound environment. Clinical observation and assessment may not be sufficient to identify a wound with elevated protease activity that can break down ECM, affect wound fibroblasts, and impair growth factor response. Future Directions: Collagen dressings that target broad-spectrum excessive MMP levels and can be applied early in the course of care may positively impact healing rates in difficult wounds. Next-generation collagen dressings offer broader MMP reduction capacity while providing a provisional dermal matrix or ECM. SCOPE AND SIGNIFICANCESelecting treatment based on a scientific understanding of the pathological condition of a chronic wound is important in addressing cost and patient needs. Harmful effects of excessive metalloproteinase (MMP) activity in chronic wound healing should be a consideration of wound care decision making. Collagen dressings have been shown to reduce MMP levels, acting as a sacrificial substrate for excessive proteases in chronic wounds. 1-3New ovine-based collagen extracellular matrix (CECM) dressings (EndoformÔ dermal template; Hollister Wound Care, Libertyville, IL) exhibit broad-spectrum MMP inhibition and can serve as a provisional matrix to affect cellular signaling and differentiation that may enhance wound healing. 2 TRANSLATIONAL RELEVANCEDegradation of collagen is important for the physiological remodeling of connective tissues during wound healing. Extracellular degradation of collagen fibers is mediated by MMPs and is a multistep process. A collagen dressing with a preserved structural component can serve as a provisional ECM dermal template and influence cellular interaction necessary to encourage keratinocyte migration. 4 CECM dressings have been shown to retain the complex collagen architecture of native tissue ECM as well as the ECM-associated secondary molecules, including laminin, fibronectin, and glycosam...

Functional Biomaterials for Treatment of Chronic Wound

“…The components of the dressing can be directly degraded by MMPs, thereby reducing the consumption of Col in the ECM. The 3D structure provided can provide space for vascular regeneration and keratinocyte migration, effectively promoting wound repair (Liden and May, 2013;Bohn et al, 2016).…”

An effective range of polydeoxyribonucleotides is critical for wound healing quality

“…Treatment with PDRN increases the collagen portion in wounded skin. The normal wound healing process primarily progresses based on the balance between collagen synthesis and collagen catabolism by matrix metalloproteinases (MMPs), and the adult wound bed predominantly contains type I collagen deposition during ECM remodeling (22). To determine whether classic PDRN affected collagen fiber accumulation, Masson's Trichrome staining was examined to analyze collagen composition.…”

Bovine Based Collagen Dressings in Wound Care Management

“…At present, wound healing is one of the common health issues, where it was estimated that chronic nonhealing wounds impact around $8.2 billion (15%) of Medicare beneficiaries. Consequently, it was also conservatively estimated that around $31.7 billion to $96.8 billion were spent annually for primary and secondary diagnosis of the wounds [17].…”

“…Wound dressings and their application in the types of wound are discussed in Table 2. belongs to the bioactive wound dressings which are made up of collagen obtained from various sources such as bovine, porcine, marine, avian, chicken, equine and many more [1,17,18]. They are commonly available in the form of particles, astes, gels, pads, ropes, sheets or solutions.…”