Overweight Is an Additional Prognostic Factor in Acute Pancreatitis: A Meta-Analysis

Wang, Shi-qi; Li, Shujun; Feng, Quanxin; Feng, Xiaoqin; Xu, Lei; Zhao, Qingchuan

doi:10.1159/000327688

Cited by 58 publications

(26 citation statements)

References 15 publications

(57 reference statements)

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“…16,21 Several tests can help differentiate biliary pancreatitis from other causes of pancreatitis, such as aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and serum bilirubin, 22 which are the standard liver function tests and should be reviewed before making a confident diagnosis. 27 We noticed that body weight can predict the clinical severity of AP with significant P value (P = 0.009; Table 2). 22,23 Notably, the incidence of AP is increasing, paralleled with an increase in the prevalence of obesity.…”

Section: Discussionmentioning

confidence: 86%

Does the Presence of Obesity and/or Metabolic Syndrome Affect the Course of Acute Pancreatitis?

et al. 2014

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Section: Discussionmentioning

confidence: 86%

Does the Presence of Obesity and/or Metabolic Syndrome Affect the Course of Acute Pancreatitis?

et al. 2014

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“…4 The association of visceral fat and poor outcomes may originate from its propensity to release cytokines and its necrosis predisposing to pseudocyst and acute fluid collection formation, particularly when the necrotic region becomes infected and may therefore lead to an increased risk of local complications. 8 , 20 The study by O'Leary, however, did not find any association between visceral fat volume and increased local complications. 13 What is not clear from these reports, however, is the potential for confounding factors such as comorbidities related to obesity-associated metabolic syndrome, hypertension and diabetes, which were not routinely evaluated and may have an impact on outcome.…”

Section: Discussionmentioning

confidence: 94%

Is Abdominal Fat Distribution Measured by Axial CT Imaging an Indicator of Complications and Mortality in Acute Pancreatitis?

Hall

Stephenson

Jones

et al. 2015

Journal of Gastrointestinal Surgery

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“…Several independent studies have also confirmed this observation [4][5][6]. Visceral obesity, which is a component of metabolic syndrome, has been recognized to have a stronger correlation with poor outcomes in patients with AP [1][2][3][4][5][6][7]. NAFLD is an objective marker of visceral obesity.…”

Section: Introductionmentioning

confidence: 81%

“…Results from meta-analysis show that obesity (defined as BMI>30) was associated with significantly higher incidence of systemic and local complication and higher rate of mortality from AP [1][2][3]. Several independent studies have also confirmed this observation [4][5][6].…”

Section: Introductionmentioning

confidence: 83%

NAFLD Diagnosed with Abdominal Ultrasound is a Marker of Severity in Acute Pancreatitis

Jasdanwala¹

2015

J Gastrointest Dig Syst

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Objective: Obesity, particularly metabolic obesity, is associated with an increased incidence and enhanced severity of acute pancreatitis (AP). Non Alcoholic Fatty Liver Disease (NAFLD) is a marker of metabolic obesity, which can be easily diagnosed, with the help of initial abdominal ultrasound (AUS) routinely performed in all patients with AP upon admission to assess a biliary etiology. The aim of this study is to identify the clinical utility of detecting NAFLD by AUS in determining the severity of patients with AP Methods: Five hundred and seventy four patients with non-alcoholic AP were divided into two groups on the basis of presence or absence of NAFLD detected by AUS at the time of admission. The diagnosis of NAFLD was based solely on imaging findings. Well-established single markers of prognosis as well as scoring systems were studied in both groups. The data was analyzed using the student's t-test, chi-square test and multivariate regression analysis. Results:Patients with NAFLD had a more severe disease as compared to patients without NAFLD as measured by single markers of prognosis like serum albumin, mean length of stay, ICU admission and mortality as well as scoring systems like BISAP score and Modified Atlanta Classification system ( P value < 0.05) BMI, by itself, was not associated with any difference in outcomes in patients with and without NAFLD as assessed by multivariate regression analysis. Age, sex and individual components of metabolic syndrome also had no influence on the prognostic markers Conclusion: Presence of NAFLD as diagnosed by early AUS can be used as an additional single marker of prognosis in AP. The diagnosis of NAFLD is objective and almost always available at the time of initial presentation of AP.

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Overweight Is an Additional Prognostic Factor in Acute Pancreatitis: A Meta-Analysis

Cited by 58 publications

References 15 publications

Does the Presence of Obesity and/or Metabolic Syndrome Affect the Course of Acute Pancreatitis?

Does the Presence of Obesity and/or Metabolic Syndrome Affect the Course of Acute Pancreatitis?

Is Abdominal Fat Distribution Measured by Axial CT Imaging an Indicator of Complications and Mortality in Acute Pancreatitis?

NAFLD Diagnosed with Abdominal Ultrasound is a Marker of Severity in Acute Pancreatitis

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