Overweight during development dysregulates cellular metabolism and critical genes that control food intake in the prefrontal cortex

Silva, Severina Cassia de Andrade; de Lemos, Maria Daniele Teixeira; dos Santos Junior, Osmar Henrique; Rodrigues, Thyago Oliveira; Silva, Tercya Lucidi; da Silva, Aline Isabel; Fiamoncini, Jarlei; Lagranha, Claudia J.

doi:10.1016/j.physbeh.2023.114453

Cited by 3 publications

(2 citation statements)

References 60 publications

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“…According to the World Obesity Atlas 2023, over 4 billion adults and nearly 3 million children will be overweight or obese by 2035, a significant global health concern. 88 R. gnavus has been found to be significantly more abundant in obese https://doi.org/10.2147/DMSO.S456173…”

Section: Role Of R Gnavus In Obesitymentioning

confidence: 99%

An Update on the Role and Potential Molecules in Relation to Ruminococcus gnavus in Inflammatory Bowel Disease, Obesity and Diabetes Mellitus

Hong,

Fu,

Liu

et al. 2024

DMSO

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Ruminococcus gnavus (R. gnavus) is a gram-positive anaerobe commonly resides in the human gut microbiota. The advent of metagenomics has linked R. gnavus with various diseases, including inflammatory bowel disease (IBD), obesity, and diabetes mellitus (DM), which has become a growing area of investigation. The initial focus of research primarily centered on assessing the abundance of R. gnavus and its potential association with disease presentation, taking into account variations in sample size, sequencing and analysis methods. However, recent investigations have shifted towards elucidating the underlying mechanistic pathways through which R. gnavus may contribute to disease manifestation. In this comprehensive review, we aim to provide an updated synthesis of the current literature on R. gnavus in the context of IBD, obesity, and DM. We critically analyze relevant studies and summarize the potential molecular mediators implicated in the association between R. gnavus and these diseases. Across numerous studies, various molecules such as methylation-controlled J (MCJ), glucopolysaccharides, ursodeoxycholic acid (UDCA), interleukin(IL)-10, IL-17, and capric acid have been proposed as potential contributors to the link between R. gnavus and IBD. Similarly, in the realm of obesity, molecules such as hydrogen peroxide, butyrate, and UDCA have been suggested as potential mediators, while glycine ursodeoxycholic acid (GUDCA) has been implicated in the connection between R. gnavus and DM. Furthermore, it is imperative to emphasize the necessity for additional studies to evaluate the potential efficacy of targeting pathways associated with R. gnavus as a viable strategy for managing these diseases. These findings have significantly expanded our understanding of the functional role of R. gnavus in the context of IBD, obesity, and DM. This review aims to offer updated insights into the role and potential mechanisms of R. gnavus, as well as potential strategies for the treatment of these diseases.

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Section: Role Of R Gnavus In Obesitymentioning

confidence: 99%

An Update on the Role and Potential Molecules in Relation to Ruminococcus gnavus in Inflammatory Bowel Disease, Obesity and Diabetes Mellitus

Hong,

Fu,

Liu

et al. 2024

DMSO

View full text Add to dashboard Cite

show abstract

“…Obesity has become a serious health problem as it increases the risk of chronic diseases, such as cardiovascular disease, hypertension, type 2 diabetes, and certain types of cancer. Evidence shows that the prevalence of obesity is increasing globally, with an estimated 4 billion people expected to be obese by 2035 [2]. Considering the wide range of complications and the increased metabolic burden caused by obesity, preventing obesity is essential to regulating physical and mental health.…”

Section: Introductionmentioning

confidence: 99%

The Lipid-Metabolism-Associated Anti-Obesity Properties of Rapeseed Diacylglycerol Oil

Mao,

Zheng,

et al. 2024

Nutrients

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To investigate the effects of rapeseed diacylglycerol oil (RDG) intake on lipid accumulation and metabolism in C57BL/6J mice, obese mice were fed a high-fat diet in which 45% of the total energy content came from RDG (RDGM group) or rapeseed triacylglycerol oil (RTGM group). This diet intervention was conducted for 12 weeks following the establishment of the obese mouse model. By the end of the experiment, the serum glucose levels of the mice in the RTGM and RDGM groups were 13.0 ± 1.3 mmol/L and 9.7 ± 1.5 mmol/L, respectively. Meanwhile, the serum triglyceride level in the RDGM group was 26.3% lower than that in the RTGM group. The weight-loss effect in the RDGM group was accompanied by a significant decrease in the white adipose tissue (WAT) index. The RDG intervention did not significantly change the antioxidant and anti-inflammatory properties of the rapeseed oil in vivo. The RDG diet improved the liver lipid metabolism abnormalities induced by a high-fat diet, leading to decreased liver damage index values (AST and ALT). Additionally, compared to that in the RTGM group, the expression of the adipogenic genes PPAR-γ and DGAT decreased in both the liver and intestine by 21.7% and 16.7% and by 38.7% and 47.2%, respectively, in the RDGM group. Further, most lipolytic genes in BAT showed no significant change after the RDG intervention. This implies that RDG regulates lipid metabolism by altering the expression of adipogenic genes in the liver, intestine, and adipose tissue, thereby reducing the accumulation of WAT. Furthermore, the RDG diet enhanced gut flora diversity, increasing the relative levels of unclassified Muribaculaceae and decreasing the levels of Dubosiella and Faecalibaculum in the mouse gut, potentially accelerating lipid metabolism. Thus, a three-month RDG diet intervention in obese mice exhibited benefits in regulating the somatotype, serum obesity-related indices, gut flora structure, and lipid metabolism in the adipose tissue, liver, and intestine.

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GLP-1R agonists: Full of hope, use with caution

Xu,

2024

TIME

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Overweight during development dysregulates cellular metabolism and critical genes that control food intake in the prefrontal cortex

Cited by 3 publications

References 60 publications

An Update on the Role and Potential Molecules in Relation to Ruminococcus gnavus in Inflammatory Bowel Disease, Obesity and Diabetes Mellitus

An Update on the Role and Potential Molecules in Relation to Ruminococcus gnavus in Inflammatory Bowel Disease, Obesity and Diabetes Mellitus

The Lipid-Metabolism-Associated Anti-Obesity Properties of Rapeseed Diacylglycerol Oil

GLP-1R agonists: Full of hope, use with caution

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