Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis

Sandberg, Maria; Bengtsson, Camilla; Källberg, Henrik; Wesley, Annmarie; Klareskog, Lars; Alfredsson, Lars; Saevarsdóttir, Saedís

doi:10.1136/annrheumdis-2013-205094

Cited by 135 publications

(130 citation statements)

References 20 publications

(26 reference statements)

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“…Установлено, что коморбидность влияет на про-должительность жизни, функциональный статус и качест-во жизни пациентов независимо от активности заболева-ния, снижает эффективность терапии и увеличивает риск НР. Например, отмечена связь между увеличением индек-са массы тела [112][113][114][115], курением [116][117][118][119] и снижением вероятности достижения ремиссии на фоне лечения БПВП и ГИБП.…”

Section: таблицаunclassified

The 2016 Eular Guidelines for the Diagnosis and Treatment of Early Arthritis

Насонов¹

2017

rsp

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Section: таблицаunclassified

The 2016 Eular Guidelines for the Diagnosis and Treatment of Early Arthritis

Насонов¹

2017

rsp

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“…Some of them reported positive relationships for BMI and disease outcomes such as DAS28, 4,15,[37][38][39] HAQ, 4,15,17,37,39 rheumatoid factor 7 and/or Sharp total score, 39 while another study reported no relationship between obesity and DAS28 or HAQ, but demonstrated an association with modified Sharp/van der Heijde score. 40 It has The strengths of our study are the large number of participants and disease outcomes such as disease activity, disability, quality of life, structural damage, and real-life experience within the scope of National Registry.…”

Section: Underweigh (N=13)mentioning

confidence: 99%

Obesity Associated With Active, but Preserved Joints in Rheumatoid Arthritis: Results From our National Registry

et al. 2016

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Objectives: This study aims to investigate the prevalence of obesity in patients with rheumatoid arthritis (RA) and associations with disease outcomes. Patients and methods:The study population comprised of 1,038 patients with RA (198 males, 840 females; mean age 56.1±12.6 years; range 19 to 94 years) who had been included in National RA-Registry. RA disease activity measures, physical function, quality of life, joint destruction, laboratory tests, as well as pain, fatigue, general health, and patient and physician global health assessments on a visual analog scale were collected. Results: Our patients had established RA with mean disease duration of 10.2±8.8 years and moderate disease activity (disease activity score in 28 joints: mean 3.7±1.6). According to the body mass index (BMI), 70% of the patients were overweight (n=362, 34.9%) or obese (n=364, 35.1%). These patients had higher disease activity scores in 28 joints, visual analog scale-pain and visual analog scale-patient global scores, and higher levels of fasting blood glucose; however, they had lower radiographic scores than normal-BMI patients (p<0.05). Regression analyses showed that the BMI was independently and inversely associated with disease activity scores in 28 joints and Sharp/van der Heijde scores after the adjustments for biologic and treatment-related factors (p<0.05). Conclusion: Our findings indicate that obesity is more common in patients with RA than the general population. High disease activity and low radiographic damage were associated with high BMI in this National RA-Registry.

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“…В данном контексте дебют/обострение любого РЗ может рассматри-ваться не только как весомый компонент мультиморбид-ности и постоянно действующий катализатор (воспале-ние, формирование своей коморбидности, тяжелые неже-лательные реакции лекарственной терапии) для других элементов, составляющих мультиморбидность, но и как следствие какого-либо компонента предшествующей мультиморбидности, например, ожирения, аденомы предстательной железы [25]. Хорошо известно, что избы-точная масса тела или ожирение являются не только пре-диктором развития псориатического артрита и ревмато-идного артрита (РА), но и определяют эффективность те-рапии этих истинно воспалительных артропатий [29,30]. В данной ситуации само РЗ является скорее коморбид-ным состоянием по отношению к ожирению, нежели ин-дексной болезнью.…”

Section: ел насонов и соавтunclassified