Background This study was conducted to provide evidence on the current status of breast cancer (BC) and its incidence trend in EMR during 1998-2018. Also, this study aimed to investigate the association between the incidence of BC and HDI and some factors related to this index, including total fertility rate (TFR), and obesity, using a meta-analysis. Method Data on incidence of BC were collected from various sources, including PubMed, Embase, Web of Science, and WHO, from 1998 to 2018 using systematic review and meta-analysis. Pooled ASR (age standardized rate) was calculated based on study duration and quality of data using a subgroup analysis and random effect metaanalysis. Results A total of 76 studies (499 data points) were analyzed. Pooled ASR of BC for EMR was 39.8 per 100 000 person-year (95% confidence interval CI, 36.01, 43.9) during 2011-2018. ASR of BC had an upward trend in EMR from 2005 to 2018. However, the increasing trend was found to be slightly different in various regions based on quality of data. Moreover, pooled ASR had a significant association with Human Development Index (HDI) -6.6 (95% CI, -8.9, -4.3) and obesity 0.1 (95% CI, 0.07, 0.1). Conclusion Pooled ASR of BC in EMR was lower than the global average. Also, the ASR value and its incremental trend have been higher in countries with low-quality data than in other countries of this region in recent years. Data quality or physiological factors, such as increase in obesity rates, could be the reasons for this incremental trend.According to World Health Organization (WHO), Eastern Mediterranean Region (EMR) comprises of 21 countries, with the population of about 583 million. The countries in this region have diverse economic, social, health indexes, and life expectancy [3].In some studies, socioeconomic factors have been mentioned as possible factors influencing BC incidence [1,4]. Human Development Index (HDI), a composite index comprised of life expectancy at birth, salary, and education, is one of the indicators used to study the level of welfare in human societies [5]. Considering the lack of proper cancer registration systems and surveillance structure in most of developing countries, particularly in EMR countries [6], and given that EMR includes countries with diverse socioeconomic and health status [3], similar patterns may be found in this region and in other similar countries in the present and future. This study was conducted to provide evidence on the current status of BC and its incidence trend in the EMR during1998-2018. Moreover, this study investigated the association between the incidence of BC and HDI and some factors related to this index, including total fertility rate (TFR) and obesity, using a meta-analysis.