Overweight and obesity negatively affect the outcomes of ovarian stimulation and<i>in vitro</i>fertilisation: a cohort study of 2628 Chinese women

Zhang, Dan; Zhu, Yimin; Gao, Huijuan; Zhou, Biao; Zhang, Runju; Wang, Tingting; Ding, Guo‐Lian; Qu, Fan; Huang, He‐Feng; Lu, Xiu-e

doi:10.3109/09513591003632100

Cited by 104 publications

(92 citation statements)

References 35 publications

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“…As seen in this work, although the majority of the articles show that obesity has a negative effect on some of the parameters analyzed, there is no consensus in the literature about their real consequences. The articles on the subject have found mixed results, which small population sample and others were conducted in populations whose characteristics are quite distinct from the others, as is the case in the study by Zhang et al (2010), in which the study population was Chinese, with different anthropometric characteristics of Westerners. Also, another factor that hampers the generalization is the difference in types of ART protocol used.…”

Section: Discussionmentioning

confidence: 98%

“…One was the study of Veleva et al (2008) , which showed that the BMI graph curve that represents how BMI affects the miscarriage rate is U-shaped, meaning that patients of low weight also has their increased risk, independent of patient age ( Figure 3 ). Moreover, the revision of Rittenberg et al, 2011 revealed increased miscarriage rate in 14 studies (RR 1.36, 95 % CI 1.13 to 1.64, p et al, 2010, despite the rate being increased, this increase was not significant, as in Vilarino et al, 2011, Zhang et al, 2010and Sathya et al .,2010. Sneed et al, 2008 showed that miscarriage rate is not directly affected by BMI, but by the interaction between BMI and age, with age the main determining factor.…”

Section: Miscarriage Ratementioning

confidence: 99%

“…In Orvieto et al, 2009, about 30 ± 15 ampoules were used in patients which BMI was less than 30 and 38 ± 15 ampoules in obese patients (p < 0.001). Zhang et al, 2010, showed that the dose in patients with BMI in the normal range was 2587 ± 933 and 3272 ± 1798 in obese (p < 0.05). In Bellver et al, 2010, this result was also found with p value of 0.001.…”

Section: Dose Of Gonadotropinsmentioning

confidence: 99%

“…Bellver et al, 2010 divided the patients into 4 groups according to their BMI: < 20, 20 to 24.9, 25 to 29.9, and greater than 30 kg/ m². The LBR in patients within the normal range was 31.3 % and 23.7 % in obese patients (p of BMI increased above the normal unit is 0.981 (95 % CI 0.967 to 0.995) for the LBR (p Zhang et al, 2010 showed that there was no difference in this rate between patients with normal weight, overweight and obese ( 26.2 % vs 23.7 % vs 26 %, respectively) with p value greater than 0.05. In Sneed et al, 2008 of the woman and IVF results.…”

Section: Live Birth Ratementioning

confidence: 99%

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Obese women and in vitro fertilization: results

Koatz¹,

Souza²

2013

JBRA Assisted Reproduction

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Objective: To evaluate the effect of female obesity on the results of In Vitro Fertilization (IVF) in six parameters: dose of gonadotropins required, number of oocytes retrieved and fertilization, pregnancy, miscarriage and live births rates. method: Literature search in PUBMED articles in English between 2008 and 2013 using the following keywords: female, obesity and In Vitro Fertilization. 15 articles were selected for this work. Results: From the total only two articles showed that female obesity does not alter the results of IVF. The remaining 13 came to the conclusion that obesity has a negative effect on some of the parameters evaluated. However, there was no consensus about its effect. Conclusion: Further studies are needed to clarify the real role of obesity in female patients undergoing IVF, but the weight loss prior to treatment should always be encouraged. keywords: Female, Obesity and In Vitro Fertilization. RESUmOObjetivo: Avaliar o efeito da obesidade feminina nos resultados da fertilização in vitro (FIV) em seis parâmetros: recuperados e fertilização, gravidez, aborto e taxas de nascidos vivos. método: Inglês, entre 2008 e 2013, utilizando as seguintes palavraschave: mulher, obesidade e fertilização in vitro. 15 artigos foram selecionados para este trabalho. Resultados: Do total apenas dois artigos mostraram que a obesidade feminina não altera os resultados de fertilização in vitro. Os restantes 13 chegaram à conclusão de que a obesidade tem um efeito negativo sobre alguns dos parâmetros avaliados. no entanto, não houve consenso sobre o seu efeito. Conclusão: Mais estudos são necessários para esclarecer o real papel da obesidade em pacientes do sexo feminino submetidas a fertilização in vitro, mas a perda de peso antes do tratamento deve ser sempre incentivada. Palavras-chave: feminino, obesidade e fertilização in vitro.

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Section: Discussionmentioning

confidence: 98%

Section: Miscarriage Ratementioning

confidence: 99%

Section: Dose Of Gonadotropinsmentioning

confidence: 99%

Section: Live Birth Ratementioning

confidence: 99%

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Obese women and in vitro fertilization: results

Koatz¹,

Souza²

2013

JBRA Assisted Reproduction

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“…The data is conflicting with some studies showing differences in outcome based on drug dosages across the BMI categories and others not. Overall, BMI has been shown to be inversely proportional to the number of follicles produced and directly proportional to the gonadotrophin dosage required [23] and duration of stimulation [17]. A large meta-analysis by Rittenberg et al…”

Section: Discussionmentioning

confidence: 99%

The Impact of Body Mass Index on Assisted Reproductive Treatments

Supramaniam¹,

Mittal²,

Lim³

2017

OJOG

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Multiparity amongst women with a body mass index (BMI) ≥ 30 Kg/m 2 is a common occurrence despite there being a known clear association with a decline in fecundity in women who are overweight or obese. These women, also pose further concerns, as they are at increased risk of antenatal complications such as preeclampsia and gestational diabetes. Over the years, a number of different modalities of fertility treatments have been tried and tested in this cohort of women to find the optimal treatment to improve their reproductive capacity. There has been an exponential increase in knowledge and understanding towards managing patients with a raised BMI, particularly through assisted reproductive treatments. Although the efficacies of various forms of fertility treatments have been shown to be affected by a rise in BMI, there is yet to be a definitive understanding as to the optimal management of these patients. The literature supports weight loss alone as an effective intervention in improving the reproductive capacity of women with a raised BMI with unexplained infertility. Furthermore, if live birth rate is taken as the desired outcome measure, then ovarian drilling and in vitro fertilisation (IVF) treatment have been shown to yield the best results in overweight and obese patients when comparisons are drawn to other interventions such as natural conception and treatment with clomiphene citrate.

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Guardians of Oocyte Quality

Ruebel

Latham

2018

Encyclopedia of Life Sciences

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Oocyte quality is fundamental to assisted reproduction, agricultural livestock productivity and species preservation. Mammalian oocytes develop in close coordination with somatic follicle cells of the ovary, and manifest remarkable molecular mechanisms that serve as guardians of oocyte quality and integrity. Genome and mitochondrial integrity are major aspects of oocyte quality determination. Ongoing research is revealing the details of these mechanisms, and how they help protect oocytes from detrimental effects of exogenous factors. Key Concepts Oocyte quality is essential for assisted reproduction success. Development of the oocyte involves an intricate set of bidirectional signals between the oocyte, cumulus cells and follicular fluid components, which can impact the quality of the oocyte. Chromosome segregation and adaptability to DNA damage are critical for the integrity of oocyte's genome. Energy production, proper distribution of mitochondria and regulation of fusion/fission are essential for maintaining the integrity of the mitochondria and oocyte developmental competence. Overall, oocyte maturation and development is a highly regulated process, and disruption in this process could comprise the mitochondrial and genomic integrity, further impacting the health of the oocytes. There are a variety of extrinsic factors, such as maternal health, maternal diet and environmental exposures, that can further impact oocyte quality. Therapies such as antioxidant, melatonin, CoQ10 and resveratrol treatments have been suggested to improve oocyte quality, but more studies are needed to determine efficacy. Novel biomarkers of oocyte quality need to be discovered.

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Overweight and obesity negatively affect the outcomes of ovarian stimulation andin vitrofertilisation: a cohort study of 2628 Chinese women

Abstract: Overweight and obesity are related with impared ovarian response, and negatively affect the outcomes of IVF.

Cited by 104 publications

References 35 publications

Obese women and in vitro fertilization: results

Obese women and in vitro fertilization: results

The Impact of Body Mass Index on Assisted Reproductive Treatments

Guardians of Oocyte Quality

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