Overweight and obesity in children with newly diagnosed inflammatory bowel disease

Pituch-Zdanowska, Aleksandra; Banaszkiewicz, Aleksandra; Dziekiewicz, Marcin; Łazowska-Przeorek, Izabella; Gawrońska, Agnieszka; Kowalska-Duplaga, Kinga; Iwańczak, Barbara; Klincewicz, Beata; Grzybowska-Chłebowczyk, Urszula; Walkowiak, Jarosław; Albrecht, Piotr

doi:10.1016/j.advms.2015.07.004

Cited by 27 publications

(25 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings were similar to other series [ 22 23 24 25 26 ], with most children and teens having BMI in the normal range. Kugathasan et al [ 22 ] reviewed 2 North American cohorts of IBD patients, the rate of patients with BMI >85th percentile for age in each cohort, was 9–10% for patients with CD, and 20–34% for patients with UC.…”

Section: Discussionsupporting

confidence: 92%

“…Kugathasan et al [22] reviewed 2 North American cohorts of IBD patients, the rate of patients with BMI >85th percentile for age in each cohort, was 9-10% for patients with CD, and 20-34% for patients with UC. Pituch-Zdanowska and collaborators [23] [24] from Canada reported a Cohort of 139 pediatric patients with IBD, at presentation 71% had a normal BMI, 9.4% where overweight, 7.2% were obese, and 16.6% where either obese or overweight. Obesity was more common in patients with UC 12.7%, than in patients with CD 0.0%, 9% of both overweight and obese patients were overweight ( Table 2) [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…Kugathasan et al [ 22 ] reviewed 2 North American cohorts of IBD patients, the rate of patients with BMI >85th percentile for age in each cohort, was 9–10% for patients with CD, and 20–34% for patients with UC. Pituch-Zdanowska and collaborators [ 23 ] report a retrospective review of 5 children's hospitals in Poland, finding that 4.3% of patients with CD and 15.7% of patients with UC are either obese or overweight. Recently Chandrakumar et al [ 24 ] from Canada reported a Cohort of 139 pediatric patients with IBD, at presentation 71% had a normal BMI, 9.4% where overweight, 7.2% were obese, and 16.6% where either obese or overweight.…”

Section: Discussionmentioning

confidence: 99%

“…Recently Chandrakumar et al [ 24 ] from Canada reported a Cohort of 139 pediatric patients with IBD, at presentation 71% had a normal BMI, 9.4% where overweight, 7.2% were obese, and 16.6% where either obese or overweight. Obesity was more common in patients with UC 12.7%, than in patients with CD 0.0%, 9% of both overweight and obese patients were overweight ( Table 2 ) [ 23 24 25 ].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Body Mass Index at Presentation of Inflammatory Bowel Disease in Children

Carbonell

Chandan

2020

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

Purpose: The evidence for an association between inflammatory bowel disease (IBD) and obesity is conflicting. Therefore, we set out to review the body mass index (BMI) at presentation of IBD to understand if the rise of the obesity rate in the general population, lead to an increase of obesity in patients with IBD at the time of diagnosis. Methods: Retrospective review of all patients with IBD seen at Children's Hospital and Medical Center from January 1st 2010 to December 31st 2014. From the initial visit and endoscopy, we obtained: age; sex; BMI; disease phenotype; disease severity. Results: We had a total of 95 patients, 35 patients were excluded due to incomplete data or referral being made after diagnosis was made. 28 were males and 32 were females, Age range was 2-17 years. A 37 had Crohn's disease, 19 ulcerative colitis, and 4 indeterminate colitis. Disease severity in 19 cases was mild, 29 moderate and 12 severe. BMI distribution was as follows-obese (5.0%), overweight (6.7%), normal weight (65.0%), mild malnutrition (8.3%), moderate malnutrition (15.0%), severe malnutrition (1.7%). Conclusion: Our data is consistent with other series. Showing most children had a normal BMI, regardless of disease severity or phenotypes. One confounding factor is the possibility of delay in referral to GI. This could mean some obese children may fall in the normal BMI range at the time of diagnosis due to ongoing weight loss. Future studies should include prospective cohort studies, comparing incidence of IBD in obese and non-obese patients, severity at presentation, duration of symptoms, and clinical outcomes.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Body Mass Index at Presentation of Inflammatory Bowel Disease in Children

Carbonell

Chandan

2020

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

show abstract

“…Interestingly, the unaffected CD first-degree relative subjects used in this study had high BMI, known to be associated to inflammation and a dysbiosed microbiota [ 52 ]. This observation is in accordance with an inflammatory status predisposing to CD and raises the controversial question of whether being overweight is an initial step before appearance of CD disease [ 53 – 55 ].…”

Section: Discussionsupporting

confidence: 59%

Unique β-Glucuronidase Locus in Gut Microbiomes of Crohn’s Disease Patients and Unaffected First-Degree Relatives

Gloux

Anba‐Mondoloni

2016

PLoS ONE

View full text Add to dashboard Cite

Crohn’s disease, an incurable chronic inflammatory bowel disease, has been attributed to both genetic predisposition and environmental factors. A dysbiosis of the gut microbiota, observed in numerous patients but also in at least one hundred unaffected first-degree relatives, was proposed to have a causal role. Gut microbiota β-D-glucuronidases (EC 3.2.1.33) hydrolyse β-D-glucuronate from glucuronidated compounds. They include a GUS group, that is homologous to the Escherichia coli GusA, and a BG group, that is homologous to metagenomically identified H11G11 BG and has unidentified natural substrates. H11G11 BG is part of the functional core of the human gut microbiota whereas GusA, known to regenerate various toxic products, is variably found in human subjects. We investigated potential risk markers for Crohn’s disease using DNA-sequence-based exploration of the β-D-glucuronidase loci (GUS or Firmicute H11G11-BG and the respective co-encoded glucuronide transporters). Crohn’s disease-related microbiomes revealed a higher frequency of a C7D2 glucuronide transporter (12/13) compared to unrelated healthy subjects (8/32). This transporter was in synteny with the potential harmful GUS β-D-glucuronidase as only observed in a Eubacterium eligens plasmid. A conserved NH2-terminal sequence in the transporter (FGDFGND motif) was found in 83% of the disease-related subjects and only in 12% of controls. We propose a microbiota-pathology hypothesis in which the presence of this unique β-glucuronidase locus may contribute to an increase risk for Crohn’s disease.

show abstract