Overweight and Obesity as Risk Factors for Atrial Fibrillation or Flutter: The Danish Diet, Cancer, and Health Study

Frost, Lars; Hune, Lone Juul; Vestergaard, Peter

doi:10.1016/j.accreview.2005.08.249

Cited by 79 publications

(124 citation statements)

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“…Our results utilizing updated BMI measures are consistent with data from other population based cohort studies utilizing a single measure of BMI8, 9, 22–24, although the linear relationship observed here was not apparent in all of the individual studies. In a meta-analysis of 5 population based cohorts 10, baseline BMI was associated with a graded risk of AF, with estimated risk elevations of 39% and 87% in the overweight and obese respectively as compared to those of normal weight.…”

Section: Discussionsupporting

confidence: 88%

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The Long- and Short-Term Impact of Elevated Body Mass Index on the Risk of New Atrial Fibrillation

Tedrow

Conen

Ridker

et al. 2010

Journal of the American College of Cardiology

421

272

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Objectives To characterize the relationship between changes in body mass index (BMI) and incident atrial fibrillation (AF) in a large cohort of women. Background Obesity and AF are increasing public health problems. The importance of dynamic obesity-associated AF risk is uncertain, and mediators are not well characterized. Methods Cases of AF were confirmed by medical record review in 34,309 participants in the Women’s Health Study. Baseline and updated measures of BMI were obtained from periodic questionnaires. Results Over 12.9 +/− 1.9 years of follow-up, 834 AF events were confirmed. BMI was linearly associated with AF risk, with a 4.7% (95% CI 3.4, 6.1, p<0.0001) increase in risk with each kg/m2. Adjustment for inflammatory markers minimally attenuated this risk. When updated measures of BMI were utilized to estimate dynamic risk, overweight (HR 1.22 95%CI 1.02, 1.45, p=0.03) and obesity (HR 1.65 95%CI 1.36, 2.00, p<0.0001) were associated with adjusted short term elevations in AF risk. Participants becoming obese during the first 60 months had a 41% adjusted increase in risk of developing AF (p=0.02) compared to those maintaining BMI <30 kg/m2. The prevalence of overweight and obesity increased over time. The adjusted proportion of incident AF attributable to short term elevations in BMI was substantial (18.3%). Conclusions In this population of apparently healthy women, BMI was associated with short and long term elevations in AF risk, accounting for a large proportion of incident AF independent of traditional risk factors. A strategy of weight control may reduce the increasing incidence of AF.

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Section: Discussionsupporting

confidence: 88%

“…Several prospective studies have reported significant associations between obesity and incident AF8–10. However, how weight change influences the risk of incident AF and what proportion of the rapid increase in AF prevalence is attributable to obesity are uncertain.…”

Section: Introductionmentioning

confidence: 99%

The Long- and Short-Term Impact of Elevated Body Mass Index on the Risk of New Atrial Fibrillation

Tedrow

Conen

Ridker

et al. 2010

Journal of the American College of Cardiology

421

272

View full text Add to dashboard Cite

show abstract

“…;10;12;25 The developed risk prediction model comprising the strongest risk factors performed similarly in younger and older individuals. Valvular heart disease and heart failure were dominant factors in the risk estimation of younger individuals whereas, with increasing age, they were less strongly associated with AF risk.…”

Section: Discussionmentioning

confidence: 90%

Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study

et al. 2009

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“…14 Other population-based studies have shown a similar correlation between AF and obesity. 15, 16 The striking increase in the prevalence of obesity in Olmsted County, Minnesota over the past 20 years has paralleled that of AF. 17 The strength of the evidence suggests these findings are likely more than coincidental, and that OSA may be an important mediator in the relationship between AF and obesity.…”

Section: Obstructive Sleep Apnea—pathophysiologic Mechanismsmentioning

confidence: 99%

Sleep-Disordered Breathing and Atrial Fibrillation

Caples

Somers

2009

Progress in Cardiovascular Diseases

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Overweight and Obesity as Risk Factors for Atrial Fibrillation or Flutter: The Danish Diet, Cancer, and Health Study

Cited by 79 publications

References 0 publications

The Long- and Short-Term Impact of Elevated Body Mass Index on the Risk of New Atrial Fibrillation

The Long- and Short-Term Impact of Elevated Body Mass Index on the Risk of New Atrial Fibrillation

Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study

Sleep-Disordered Breathing and Atrial Fibrillation

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