Background: The global epidemic of overweight/obesity – termed “globesity” is a major public health problem where rates of obesity have tripled in developing countries over the last 20 years. Factors like studying in private schools, consumption of unhealthy diet, insufficient physical activity and shortened night-time sleep duration are shown to be related with overweight and obesity. Hence, this study aims to assess the prevalence of overweight/obesity and the relationship of BMI with the socio-demographic and lifestyle factors.Methods: A school based descriptive, cross-sectional study was conducted among 400 participants chosen randomly from grade 11 and 12. Measurements of height and weight were taken to calculate BMI and primary data about determinants of obesity was collected through semi structured questionnaire. The data was entered and analyzed using SPSS 16v.Results: Prevalence of overweight and obesity was 4.25% and 2.25% respectively. Consumption of fast food and sugary drinks was found among 99% and 95% of the respondents respectively. Higher screening time for TV/Computer, shortened sleep duration and reduced physical activity led to higher prevalence of overweight/obesity. Factors like type of school [esp. private school, (p=0.019, 95% CI)], type of family (p=0.039, 95% CI), occupation of mother (p=0.019, 95% CI) were statistically significant with BMI.Conclusions: Apart from under-nutrition problem, there exists increasing trend of over-nutrition among higher secondary students in Tulsipur Municipality, Nepal. The shift of under-nutrition problem to over-nutrition says we need to rethink about the consequences of over-nutrition.