Overview: Traffic at atomic resolution

Genetic disorders of cellular trafficking

“…Vesicular transport enables proteins in membrane-bound vesicles to move between the cell compartments, including the plasma membrane [2]. Today, cutting-edge structural methods, biochemical, computational approaches, and descriptions of new mechanisms and genes involved in these processes, pushes the understanding of cell trafficking and related diseases to unprecedented levels of complexity [3]. The recent discovery of a new mechanism regarding the exchange of signals and metabolites at regions where organelles form functional contacts, 'membrane contact sites' [4] together with other mechanisms of cargo moving and molecular processing such as autophagy and transport along the cytoskeleton, lead us to propose a more inclusive and clinical oriented concept of 'cell trafficking'.…”