Overview, prevention and management of chemotherapy extravasation

Kreidieh, Firas; Moukadem, Hiba; Saghir, Nagi S. El

doi:10.5306/wjco.v7.i1.87

Cited by 152 publications

(197 citation statements)

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“…In this sense, the construction and application of protocols and policies that emphasize such behaviors becomes essential in clinical practice. 19 Regarding the knowledge of the protocol of institutional extravasation, 87.5% of the participants claimed that they knew it, contradicting the results found. The protocols contribute to the standardization of actions for certain events, proving to be a managerial tool of great impact and maintenance of the quality of the care provided.…”

contrasting

confidence: 56%

“…17 The importance of the knowledge regarding the use of hot compresses, in cases of extravasation by drugs like Vincristine and Vimblastine, is given since this technique can contribute to the reduction of tissue damages, since the heat causes the vasodilation and contributes to the absorption of the minimizing its damage. 19 Also as part of the treatment pipeline, there is the extension of care at home, and the professional of the Nursing team should provide all guidance to the individual, family and caregivers on how to proceed. Thus, it was observed that all professionals showed that avoiding sun exposure is a correct orientation; and 93.7% indicate the demand of the health service in the face of the appearance of blisters, ulcerations or necrosis.…”

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confidence: 99%

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Conhecimento da equipe de enfermagem acerca da prevenção e manejo de extravasamento de drogas quimioterápicas

Cruz

Gozzo

Santos

2017

Rev enferm UFPE on line.

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Objective: to identify the knowledge of the professionals of the Nursing team about the prevention and management of extravasation of chemotherapy drugs during cancer treatment. Method: a quantitative, descriptive and cross-sectional study with 16 Nursing professionals working in a hospital in the interior of the state of São Paulo (SP), Brazil. A self-administered questionnaire was used, composed of socio-demographic variables, questions about professional practice time, oncological activity time and training on chemotherapy administration. Results: it was observed that 62.5% of the professionals did not know the order of choice of the peripheral puncture; 12.5%, that chemotherapeutic agents can not be administered to limbs with motor alterations; 43.7%, that increased infusion resistance is an indication of extravasation; 75% are unaware of the use of the hot compress for certain chemotherapeutic agents; and 87.5% reported knowing the institution's extravasation protocol. Conclusion: there is a need for structuring a permanent education program due to the lack of technical and scientific knowledge about the prevention and management of extravasation by chemotherapeutic drugs. Descriptors: Nursing; Knowledge; Drug Therapy. RESUMOObjetivo: identificar o conhecimento dos profissionais da equipe de Enfermagem acerca da prevenção e manejo do extravasamento de drogas quimioterápicas durante o tratamento oncológico. Método: estudo quantitativo, descritivo e transversal, com 16 profissionais da equipe de Enfermagem que atuam em um hospital no interior do Estado de São Paulo (SP), Brasil. Utilizou-se um questionário autoaplicável composto por variáveis sociodemográficas, questões sobre o tempo de exercício profissional, tempo de atuação na área oncológica e treinamentos sobre administração de quimioterápicos. Resultados: observou-se que 62,5% dos profissionais não sabiam a ordem de escolha da punção periférica; 12,5%, que agentes quimioterápicos não podem ser administrados em membros com alterações motoras; 43,7%, que o aumento da resistência da infusão é um sinal indicativo de extravasamento; 75% desconhecem o uso da compressa quente para determinados quimioterápicos e 87,5% referiram que conhecem o protocolo de extravasamento da instituição. Conclusão: nota-se a necessidade de estruturação de um programa de educação permanente devido à carência de conhecimentos técnicos e científicos acerca da prevenção e manejo do extravasamento por drogas quimioterápicas. Descritores: Enfermagem; Conhecimento; Quimioterapia. RESUMENObjetivo: identificar el conocimiento de los profesionales del equipo de Enfermería acerca de la prevención y manejo de la extravasación de drogas quimioterápicas durante el tratamiento oncológico. Método: estudio cuantitativo, descriptivo y transversal, con 16 profesionales del equipo de Enfermería que actúan en un hospital en el interior del Estado de São Paulo (SP), Brasil. Se utilizó un cuestionario auto aplicable compuesto por variables sociodemográficas, cuestiones sobre el tiempo de ejerci...

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contrasting

confidence: 56%

mentioning

confidence: 99%

Conhecimento da equipe de enfermagem acerca da prevenção e manejo de extravasamento de drogas quimioterápicas

Cruz

Gozzo

Santos

2017

Rev enferm UFPE on line.

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“…The data collection instrument was a structured questionnaire developed by the authors, based on the search for relevant, updated national and international literature, 3,[10][11][12] divided into the following two parts: 1) Questions about the characterization of individuals (sex, age, undergraduate studies, specialization, Master's degree, length of time working in oncology and chemotherapy, training for extravasation, number of jobs and weekly working hours); and 2) Test of knowledge with multiple choice questions, when respondents had to choose a correct answer among the alternatives given. Questions were about the classification of antineoplastic drugs, signs and symptoms of extravasation, main risk factors for extravasation, factors that influence the severity of extravasation, preventive actions, sequence of areas for peripheral venipuncture, care provided when extravasation occurs, and application of cold and hot compresses after extravasation, according to the antineoplastic drug.…”

Section: Methodsmentioning

confidence: 99%

“…The World health Organization (WHO) indicates that 27 million incident cases and nearly 17 million deaths due to cancer are expected to occur in 2030. In Brazil, estimates point to the occurrence of 600,000 new cases of cancer in 2016. Which means that this disease is an important cause of mortality, representing a great public health problem.…”

Section: Introductionmentioning

confidence: 99%

Oncological emergency: the work of nurses in the extravasation of antineoplastic chemotherapeutic drugs

Souza¹,

Bushatsky²,

Figueiredo³

et al. 2017

Escola Anna Nery - Revista De Enfermagem

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Objective: To investigate the work of nurses in the extravasation of antineoplastic chemotherapeutic drugs. Methods: A cross-sectional study with a quantitative approach was performed with a sample of 21 nurses in a referral cancer hospital.Data were collected with a semi-structured questionnaire from October to November 2015 and analyzed through simple and percentage frequency. Results: Nurses had sufficient knowledge about risk factors, prevention, and recognition of signs and symptoms of occurrence of extravasation of chemotherapeutic drugs. However, the same was not observed regarding questions about classification of antineoplastic drugs and interventions aimed at the occurrence of this health condition. Conclusion:The results found are important, as they point to questions that must be reflected upon by hospital managers and educational institutions, apart from professionals concerned with the improvement of health care for the population affected by such disease.Keywords: Extravasation of therapeutic materials and diagnoses; Antineoplastic drugs; Nursing care. resumen Objetivo: Investigar la actuación de los enfermeros en la extravasación de quimioterápicos antineoplásicos. Métodos: Estudio transversal, cuantitativo, realizado en un hospital de referencia en oncología, con una muestra de 21 enfermeros. La recolección de datos se produjo entre octubre y noviembre de 2015, mediante la aplicación del cuestionario semiestructurado; analizados por frecuencia simple y percentual. Resultados: Los participantes demostraron suficiente conocimiento acerca de los factores de riesgo, la prevención y el reconocimiento de los signos y síntomas de la ocurrencia de extravasación por la quimioterapia. No fueron consultados para cuestiones relacionadas con: clasificación de los fármacos antineoplásicos e intervenciones dirigidas a la ocurrencia del agravo. Conclusión: Los resultados de este estudio son importantes y apuntan para cuestiones que deben ser reflejadas por los gerentes de hospitales y centros de formación, así como los profesionales que se preocupen con la mejoría de la asistencia a la población afectada por esta enfermedad.

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“…Although chemotherapy is considered one of the most effective approaches to treat cancer, it might kill, alongside the malignant cell, any normal cell that grows fast, which, in turn, may result in serious damage to patients [7][8][9]. Most of the chemotherapeutic drugs work by impairing cell division by various mechanisms including damaging DNA and inhibition of the cellular machinery involved in cell division [10].…”

Section: Introductionmentioning

confidence: 99%

Vorinostat Combined with DNMTi Epigenetically Controls the Proliferation of Lung Cancer Cells A549

2017

IJSR

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Abstract:Cancer is being considered one of the fatal diseases in the global population. Lung cancer is one of the most common malignancies in males and in several countries also in females. In the present study, we aimed at evaluating the role of different chemotherapeutic drugs belonging to three groups [Histone Deacetylase Inhibitors (HDACi), DNA Methyltransferase Inhibitors (DNMTi), and Alkylating Agents)]. Vorinostat, Carboplatin, Cyclophosphamide, Temozolomide, and Procaine were applied to A549 lung cancer cells in final concentrations of 3µM and 5µM. Drugs were incubated with the cells for 96 h. Cell viability was measured using Trypan blue exclusion test, and the obtained results showed a significant decrease in the cells' viability after being treated. Global methylation, as an essential epigenetic mark, was quantified in the control and treated cells. The results showed a variation in the methylation patterns, since different combination yielded different methylation profiles. Vorinostat combined with Carboplatin hypomethylated the cells under study, while Vorinostat combined with Cyclophosphamide resulted in hypermethylation of the cells. We concluded that reactivating the hypermethylated genes in the A549 lung cancer cells by combining more than one drug was significantly better than that induced by only one chemotherapeutic agent. However, these results need more confirmatory experiments.

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Overview, prevention and management of chemotherapy extravasation

Cited by 152 publications

References 50 publications

Conhecimento da equipe de enfermagem acerca da prevenção e manejo de extravasamento de drogas quimioterápicas

Conhecimento da equipe de enfermagem acerca da prevenção e manejo de extravasamento de drogas quimioterápicas

Oncological emergency: the work of nurses in the extravasation of antineoplastic chemotherapeutic drugs

Vorinostat Combined with DNMTi Epigenetically Controls the Proliferation of Lung Cancer Cells A549

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