Overview on Nanoemulsion as a recently developed approach in Drug Nanoformulation

Mahdi, Zainab H.; Maraie, Nidhal K.

doi:10.5958/0974-360x.2019.00963.6

Cited by 14 publications

(11 citation statements)

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“…Figure 1 highlights the presence of three different regions corresponding to homogeneous dispersions (dark blue region) and non-homogeneous dispersions, characterized by phase separation phenomena (light blue zone). Inside the light blue zone, only for some formulations, the sonication leads to the formation of monophasic dispersions (blue zone) [28][29][30]. To optimize the monophasic emulsions as a suitable drug delivery system (NEs), all samples in the dark blue region were sonicated for 20 min at 50 • C. The best formulation in terms of hydrodynamic diameter, ζ-potential, and PDI was selected and observed by TEM.…”

Section: Ne Design and Characterizationmentioning

confidence: 99%

Resveratrol-Loaded Nanoemulsions: In Vitro Activity on Human T24 Bladder Cancer Cells

et al. 2021

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The chemopreventive potential of Resveratrol (RV) against bladder cancer and its mechanism of action have been widely demonstrated. The physicochemical properties of RV, particularly its high reactivity and low solubility in aqueous phase, have been limiting factors for its bioavailability and in vivo efficacy. In order to overcome these limitations, its inclusion in drug delivery systems needs to be taken into account. In particular, oil-in-water (O/W) nanoemulsions (NEs) have been considered ideal candidates for RV encapsulation. Since surfactant and oil composition can strongly influence NE features and their application field, a ternary phase diagram was constructed and evaluated to select a suitable surfactant/oil/water ratio. The selected sample was deeply characterized in terms of physical chemical features, stability, release capability and cytotoxic activity. Results showed a significant decrease in cell viability after the incubation of bladder T24 cancer cells with RV-loaded NEs, compared to free RV. The selected NE formulation was able to preserve and improve RV cytotoxic activity by a more rapid drug uptake into the cells. O/W NEs represent an effective approach to improve RV bioavailability.

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Section: Ne Design and Characterizationmentioning

confidence: 99%

Resveratrol-Loaded Nanoemulsions: In Vitro Activity on Human T24 Bladder Cancer Cells

et al. 2021

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“…Figure 2 highlights the presence of three different regions corresponding to homogeneous dispersions (black region) and non-homogeneous dispersions, characterized by phase separation phenomena (light grey zone). Moreover, sonication leads to the formation of monophasic dispersions for some formulations in the non-homogeneous region (dark grey zone) [26,42,46].…”

Section: Ne Design and Characterizationmentioning

confidence: 99%

“…homogeneous dispersions (black region) and non-homogeneous dispersions, characterized by phase separation phenomena (light grey zone). Moreover, sonication leads to the formation of monophasic dispersions for some formulations in the non-homogeneous region (dark grey zone) [26,42,46]. To optimize the monophasic emulsions in the black region as a suitable drug delivery system (NEs), all samples were sonicated for 20 min at 50 °C.…”

Section: Ne Design and Characterizationmentioning

confidence: 99%

Nanoemulsions of Satureja montana Essential Oil: Antimicrobial and Antibiofilm Activity against Avian Escherichia coli Strains

et al. 2021

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Satureja montana essential oil (SEO) presents a wide range of biological activities due to its high content of active phytochemicals. In order to improve the essential oil’s (EO) properties, oil in water nanoemulsions (NEs) composed of SEO and Tween-80 were prepared, characterized, and their antimicrobial and antibiofilm properties assayed against Escherichia coli strains isolated from healthy chicken. Since surfactant and oil composition can strongly influence NE features and their application field, a ternary phase diagram was constructed and evaluated to select a suitable surfactant/oil/water ratio. Minimal inhibitory concentration and minimal bactericidal concentration of NEs, evaluated by the microdilution method, showed that the SEO NE formulation exhibited higher inhibitory effects against planktonic E. coli than SEO alone. The quantification of biofilm production in the presence of NEs, assessed by crystal violet staining and scanning electron microscopy, evidenced that sub-MIC concentrations of SEO NEs enable an efficient reduction of biofilm production by the strong producer strains. The optimized nanoemulsion formulation could ensure food safety quality, and counteract the antibiotic resistance of poultry associated E. coli, if applied/aerosolized in poultry farms.

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“…Nanoemulsions are one, and they appear to have received much attention because of their low toxicity and capacity to enhance drug bioavailability several times [ 22 , 23 ]. Nanoemulsions are isotropic mixtures of transparent or translucent oil globules distributed in an aqueous phase sustained by an interfacial coating of surfactant and cosurfactant molecules with a smaller droplet size that are kinetically stable [ 24 , 25 ]. By increasing solubility and shielding the active moiety from enzymatic degradation, they have the greatest promise for the oral administration of weakly water-soluble medicines [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Nanoformulations, and In Vitro Anticancer Activity of N-Substituted Side Chain Neocryptolepine Scaffolds

et al. 2022

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The naturally occurring neocryptolepine (5-Methylindolo [2,3-b]quinoline) and its analogs exhibited prominent anticancer and antimalarial activity. However, the main problem of this class of compounds is their poor aqueous solubility, hampering their bioavailability and preventing their clinical development. To overcome the problem of insolubility and to improve the physicochemical and the pharmacological properties of 5-Methylindolo [2,3-b]quinoline compounds, this work was designed to encapsulate such efficient medical compounds into mesoporous silica oxide nanoemulsion (SiO2NPs). Thus, in this study, SiO2NPs was loaded with three different concentrations (0.2 g, 0.3, and 0.6 g) of 7b (denoted as NPA). The findings illustrated that the nanoparticles were formed with a spherical shape and exhibited small size (less than 500 nm) using a high concentration of the synthesized chemical compound (NPA, 0.6 g) and good stabilization against agglomeration (more than −30 mv). In addition, NPA-loaded SiO2NPs had no phase separation as observed by our naked eyes even after 30 days. The findings also revealed that the fabricated SiO2NPs could sustain the release of NPA at two different pH levels, 4.5 and 7.4. Additionally, the cell viability of the produced nanoemulsion system loaded with different concentrations of NPA was greater than SiO2NPs without loading, affirming that NPA had a positive impact on increasing the safety and cell viability of the whole nanoemulsion. Based on these obtained promising data, it can be considered that the prepared NPA-loaded SiO2NPs seem to have the potential for use as an effective anticancer drug nanosystem.

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Overview on Nanoemulsion as a recently developed approach in Drug Nanoformulation

Cited by 14 publications

References 0 publications

Resveratrol-Loaded Nanoemulsions: In Vitro Activity on Human T24 Bladder Cancer Cells

Resveratrol-Loaded Nanoemulsions: In Vitro Activity on Human T24 Bladder Cancer Cells

Nanoemulsions of Satureja montana Essential Oil: Antimicrobial and Antibiofilm Activity against Avian Escherichia coli Strains

Synthesis, Nanoformulations, and In Vitro Anticancer Activity of N-Substituted Side Chain Neocryptolepine Scaffolds

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