Overview on experimental models of interactions between nanoparticles and the immune system

Najafi-Hajivar, Saeedeh; Zakeri–Milani, Parvin; Mohammadi, Hamed; Niazi, Mehri; Soleymani-Goloujeh, Mehdi; Baradaran, Behzad; Valizadeh, Hadi

doi:10.1016/j.biopha.2016.08.060

Cited by 72 publications

(55 citation statements)

References 164 publications

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“…In the future studies, it is necessary to assess the reciprocal interaction between the aminated nanomicelles and surface of biological membranes when the aminated nanomicelles are used for biomedical applications because positively charged nanomaterials can induce unexpected side effects. 45,46 However, their targeted application in the control of infectious diseases as well as cancer immunotherapy, which requires well-designed innate and adaptive immune responses, is expected to produce positive results. The aPNMs can be used as a multifunctional nanoadjuvant that can tailor the immune response in lymph nodes by the incorporation of various types of immunostimulatory compounds, eg, other TLR ligands, nucleotide-oligomerization domain ligands, and stimulator of IFN genes ligands.…”

Section: Resultsmentioning

confidence: 99%

Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes

Song

Phuengkham

Kim

et al. 2017

IJN

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In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent carboxyl groups in poly-(γ-glutamic acid) (γ-PGA) nanomicelles, the size was reduced for rapid entry into lymphatic vessels, and the immunologically inert nanomicelles were turned into potential activators of inflammasomes. Aminated γ-PGA nanomicelles (aPNMs) induced NLRP3 inflammasome activation and the subsequent release of proinflammatory IL-1β. The NLRP3-dependent inflammasome induction mechanism was confirmed through enzyme (cathepsin B and caspase-1) inhibitors and NLRP3 knockout mice model. After the aPNMs were combined with a clinically evaluated TLR3 agonist, polyinosinic–polycytidylic acid sodium salt (aPNM-IC), they triggered multiple arms of the innate immune response, including the secretion of pro-inflammatory cytokines by both inflammasomes and an inflammasome-independent pathway and the included type I interferons.

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Section: Resultsmentioning

confidence: 99%

Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes

Song

Phuengkham

Kim

et al. 2017

IJN

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“…Several authors have pointed out that the immune system's recognition of nanoparticles is influenced by the type of covering, the formation of the protein corona, the charge, and the functional group, among others. Since each nanomaterial has its own characteristics, it might modulate the immune system's response through several pathways [1,24,31,32]. …”

Section: Discussionmentioning

confidence: 99%

Long Exposure to CdS-Dextrin Nanoparticles Induces an Immunomodulatory and Anti-Inflammatory Effect in Rats

Gómez-Cansino¹,

Ja²,

Rodríguez-Fragoso³

et al. 2017

JOURNAL OF MATERIALS SCIENCE AND NANOTECHNOLOGY

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“…Where the size, shape, composition, protein binding, and administration routes of nanoparticles seem to be the main factors that contribute to the interactions with the immune system [19]. Fig.…”

Section: Resultsmentioning

confidence: 99%

Effect of Gold and Nickel Nanoparticles on Immune Proteins of Toxoplasmosis Patients

Abdulsattar

Drywall

2017

Asian J Pharm Clin Res

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Objective: An interaction between a nanoparticle and the immune system is considered desirable when it may lead to various beneficial medical applications such as vaccines, delivery of drugs, antigens or therapeutics for inflammatory and autoimmune disorders. This study aims to evaluate the impact of some immune proteins by the presence of gold and nickel nanoparticles in sera of toxoplasmosis patients.Methods: A total of 20 patients women with toxoplasmosis aged (20-40 year) attending Central Health Laboratory in Baghdad city for the period (November 2016 to February 2017) and 20 age-matched of women healthy as a control were included in this study. Results:A non-significant increase in the activity and specific activity of protease in the sera of women infected with toxoplasmosis were observed in comparison to their values in the healthy (p˃0.05). While a non-significant decrease in total protein values was reported. The results of effect of nanoparticles showed a decrease in the level of the enzyme in the presence of nanoparticles by 41.3%, while the results showed that inhibition of nickel nanoparticles was greater and 43.8%. The results indicated that IgA, IgG, and IgM levels were decreased in the presence of gold nanoparticles. In the same context, both IgA and IgG were shown to be inhibitory in the presence of nickel nanoparticles while the results showed activation of the IgM level with nickel nanoparticles. Conclusion:We conclude from this study that other studies are required to confirm our results and therefore support the possibility of using nickel nanoparticles as a support for the treatment of toxoplasmosis through its dual effect first by reducing the protease, which is essential for survival of the parasite and second by activating IgM level, which enhances the immune defense of the body against the parasite.

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Overview on experimental models of interactions between nanoparticles and the immune system

Cited by 72 publications

References 164 publications

Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes

Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes

Long Exposure to CdS-Dextrin Nanoparticles Induces an Immunomodulatory and Anti-Inflammatory Effect in Rats

Effect of Gold and Nickel Nanoparticles on Immune Proteins of Toxoplasmosis Patients

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